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Gene: MRPL9 |
Gene summary for MRPL9 |
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Gene information | Species | Human | Gene symbol | MRPL9 | Gene ID | 65005 |
Gene name | mitochondrial ribosomal protein L9 | |
Gene Alias | L9mt | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q5SZR1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65005 | MRPL9 | LZE4T | Human | Esophagus | ESCC | 4.84e-07 | 1.81e-01 | 0.0811 |
65005 | MRPL9 | LZE7T | Human | Esophagus | ESCC | 1.50e-06 | 7.23e-01 | 0.0667 |
65005 | MRPL9 | LZE8T | Human | Esophagus | ESCC | 2.65e-04 | 9.52e-02 | 0.067 |
65005 | MRPL9 | LZE20T | Human | Esophagus | ESCC | 5.31e-05 | 1.80e-01 | 0.0662 |
65005 | MRPL9 | LZE22D1 | Human | Esophagus | HGIN | 2.10e-02 | 1.52e-01 | 0.0595 |
65005 | MRPL9 | LZE22T | Human | Esophagus | ESCC | 2.44e-02 | 3.24e-01 | 0.068 |
65005 | MRPL9 | LZE24T | Human | Esophagus | ESCC | 1.09e-13 | 5.41e-01 | 0.0596 |
65005 | MRPL9 | LZE6T | Human | Esophagus | ESCC | 2.37e-06 | 4.60e-01 | 0.0845 |
65005 | MRPL9 | P1T-E | Human | Esophagus | ESCC | 3.71e-13 | 4.37e-01 | 0.0875 |
65005 | MRPL9 | P2T-E | Human | Esophagus | ESCC | 1.69e-49 | 7.77e-01 | 0.1177 |
65005 | MRPL9 | P4T-E | Human | Esophagus | ESCC | 3.58e-23 | 7.16e-01 | 0.1323 |
65005 | MRPL9 | P5T-E | Human | Esophagus | ESCC | 2.04e-38 | 7.43e-01 | 0.1327 |
65005 | MRPL9 | P8T-E | Human | Esophagus | ESCC | 6.86e-27 | 4.20e-01 | 0.0889 |
65005 | MRPL9 | P9T-E | Human | Esophagus | ESCC | 3.40e-19 | 6.47e-01 | 0.1131 |
65005 | MRPL9 | P10T-E | Human | Esophagus | ESCC | 4.88e-26 | 4.79e-01 | 0.116 |
65005 | MRPL9 | P11T-E | Human | Esophagus | ESCC | 1.24e-14 | 7.39e-01 | 0.1426 |
65005 | MRPL9 | P12T-E | Human | Esophagus | ESCC | 3.59e-30 | 5.38e-01 | 0.1122 |
65005 | MRPL9 | P15T-E | Human | Esophagus | ESCC | 2.35e-40 | 9.64e-01 | 0.1149 |
65005 | MRPL9 | P16T-E | Human | Esophagus | ESCC | 4.14e-29 | 5.53e-01 | 0.1153 |
65005 | MRPL9 | P17T-E | Human | Esophagus | ESCC | 6.35e-11 | 5.01e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301028 | Prostate | BPH | Ribosome | 104/1718 | 167/8465 | 8.04e-33 | 1.33e-30 | 8.21e-31 | 104 |
hsa03010113 | Prostate | BPH | Ribosome | 104/1718 | 167/8465 | 8.04e-33 | 1.33e-30 | 8.21e-31 | 104 |
hsa0301029 | Prostate | Tumor | Ribosome | 104/1791 | 167/8465 | 3.53e-31 | 5.84e-29 | 3.62e-29 | 104 |
hsa0301037 | Prostate | Tumor | Ribosome | 104/1791 | 167/8465 | 3.53e-31 | 5.84e-29 | 3.62e-29 | 104 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL9 | SNV | Missense_Mutation | c.227N>A | p.Arg76Gln | p.R76Q | Q9BYD2 | protein_coding | deleterious(0.01) | benign(0.424) | TCGA-C8-A26V-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | CR | |
MRPL9 | SNV | Missense_Mutation | c.81N>T | p.Gln27His | p.Q27H | Q9BYD2 | protein_coding | tolerated(0.22) | benign(0.078) | TCGA-E9-A1RB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate | SD | |
MRPL9 | SNV | Missense_Mutation | c.429N>T | p.Glu143Asp | p.E143D | Q9BYD2 | protein_coding | deleterious(0.01) | benign(0.189) | TCGA-E9-A22G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
MRPL9 | SNV | Missense_Mutation | c.173N>A | p.Arg58His | p.R58H | Q9BYD2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MRPL9 | SNV | Missense_Mutation | c.740G>T | p.Arg247Ile | p.R247I | Q9BYD2 | protein_coding | deleterious(0) | possibly_damaging(0.89) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MRPL9 | SNV | Missense_Mutation | rs146264718 | c.712G>A | p.Val238Met | p.V238M | Q9BYD2 | protein_coding | tolerated(0.08) | probably_damaging(0.947) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
MRPL9 | SNV | Missense_Mutation | c.710T>C | p.Val237Ala | p.V237A | Q9BYD2 | protein_coding | tolerated(0.06) | benign(0.221) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
MRPL9 | SNV | Missense_Mutation | novel | c.532N>G | p.Asn178Asp | p.N178D | Q9BYD2 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MRPL9 | deletion | Frame_Shift_Del | c.71delN | p.Gly24GlufsTer75 | p.G24Efs*75 | Q9BYD2 | protein_coding | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MRPL9 | SNV | Missense_Mutation | novel | c.389N>C | p.Val130Ala | p.V130A | Q9BYD2 | protein_coding | tolerated(0.08) | possibly_damaging(0.908) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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