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Gene: MRPL47 |
Gene summary for MRPL47 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MRPL47 | Gene ID | 57129 |
| Gene name | mitochondrial ribosomal protein L47 | |
| Gene Alias | CGI-204 | |
| Cytomap | 3q26.33 | |
| Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9HD33 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57129 | MRPL47 | GSM4909281 | Human | Breast | IDC | 3.69e-13 | 3.84e-01 | 0.21 |
| 57129 | MRPL47 | GSM4909282 | Human | Breast | IDC | 2.02e-13 | 4.49e-01 | -0.0288 |
| 57129 | MRPL47 | GSM4909285 | Human | Breast | IDC | 8.90e-63 | 8.73e-01 | 0.21 |
| 57129 | MRPL47 | GSM4909288 | Human | Breast | IDC | 7.87e-06 | 2.77e-01 | 0.0988 |
| 57129 | MRPL47 | GSM4909293 | Human | Breast | IDC | 1.16e-11 | 3.34e-01 | 0.1581 |
| 57129 | MRPL47 | GSM4909296 | Human | Breast | IDC | 3.70e-03 | -1.43e-02 | 0.1524 |
| 57129 | MRPL47 | GSM4909304 | Human | Breast | IDC | 1.38e-02 | 1.82e-01 | 0.1636 |
| 57129 | MRPL47 | GSM4909311 | Human | Breast | IDC | 2.44e-11 | -2.19e-01 | 0.1534 |
| 57129 | MRPL47 | GSM4909312 | Human | Breast | IDC | 1.08e-03 | -6.95e-02 | 0.1552 |
| 57129 | MRPL47 | GSM4909313 | Human | Breast | IDC | 4.78e-04 | -1.84e-01 | 0.0391 |
| 57129 | MRPL47 | GSM4909315 | Human | Breast | IDC | 2.61e-03 | 2.49e-01 | 0.21 |
| 57129 | MRPL47 | GSM4909319 | Human | Breast | IDC | 7.14e-13 | -1.88e-01 | 0.1563 |
| 57129 | MRPL47 | GSM4909320 | Human | Breast | IDC | 6.51e-04 | -2.00e-01 | 0.1575 |
| 57129 | MRPL47 | GSM4909321 | Human | Breast | IDC | 6.47e-04 | -3.16e-02 | 0.1559 |
| 57129 | MRPL47 | brca1 | Human | Breast | Precancer | 8.98e-15 | 3.97e-01 | -0.0338 |
| 57129 | MRPL47 | brca2 | Human | Breast | Precancer | 9.02e-14 | 3.48e-01 | -0.024 |
| 57129 | MRPL47 | brca3 | Human | Breast | Precancer | 4.30e-08 | 2.49e-01 | -0.0263 |
| 57129 | MRPL47 | NCCBC14 | Human | Breast | DCIS | 9.59e-07 | 1.09e-01 | 0.2021 |
| 57129 | MRPL47 | NCCBC5 | Human | Breast | DCIS | 1.26e-08 | 1.47e-01 | 0.2046 |
| 57129 | MRPL47 | NCCBC6 | Human | Breast | DCIS | 2.47e-04 | 4.13e-01 | 0.2095 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00325432 | Breast | IDC | mitochondrial translation | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
| GO:003254311 | Breast | DCIS | mitochondrial translation | 13/1390 | 76/18723 | 3.70e-03 | 2.99e-02 | 13 |
| GO:00325435 | Esophagus | HGIN | mitochondrial translation | 23/2587 | 76/18723 | 1.61e-04 | 3.16e-03 | 23 |
| GO:01400534 | Esophagus | HGIN | mitochondrial gene expression | 27/2587 | 108/18723 | 1.34e-03 | 1.57e-02 | 27 |
| GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
| GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
| GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
| GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
| GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
| GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
| GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
| GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
| GO:003254313 | Oral cavity | LP | mitochondrial translation | 43/4623 | 76/18723 | 2.85e-09 | 1.26e-07 | 43 |
| GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
| GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
| GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
| GO:01400536 | Thyroid | PTC | mitochondrial gene expression | 51/5968 | 108/18723 | 6.04e-04 | 3.83e-03 | 51 |
| GO:00325437 | Thyroid | PTC | mitochondrial translation | 38/5968 | 76/18723 | 7.52e-04 | 4.67e-03 | 38 |
| GO:014005314 | Thyroid | ATC | mitochondrial gene expression | 51/6293 | 108/18723 | 2.26e-03 | 1.06e-02 | 51 |
| GO:003254315 | Thyroid | ATC | mitochondrial translation | 38/6293 | 76/18723 | 2.26e-03 | 1.06e-02 | 38 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MRPL47 | SNV | Missense_Mutation | rs762120814 | c.700N>A | p.Leu234Ile | p.L234I | Q9HD33 | protein_coding | tolerated(0.09) | possibly_damaging(0.497) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MRPL47 | SNV | Missense_Mutation | c.273N>C | p.Arg91Ser | p.R91S | Q9HD33 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| MRPL47 | SNV | Missense_Mutation | novel | c.578N>C | p.Arg193Thr | p.R193T | Q9HD33 | protein_coding | deleterious(0.01) | benign(0.357) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| MRPL47 | SNV | Missense_Mutation | rs762120814 | c.700N>A | p.Leu234Ile | p.L234I | Q9HD33 | protein_coding | tolerated(0.09) | possibly_damaging(0.497) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| MRPL47 | SNV | Missense_Mutation | c.198A>C | p.Glu66Asp | p.E66D | Q9HD33 | protein_coding | tolerated(0.1) | benign(0.2) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| MRPL47 | SNV | Missense_Mutation | c.5N>A | p.Ala2Asp | p.A2D | Q9HD33 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.927) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
| MRPL47 | SNV | Missense_Mutation | rs762120814 | c.700N>A | p.Leu234Ile | p.L234I | Q9HD33 | protein_coding | tolerated(0.09) | possibly_damaging(0.497) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| MRPL47 | SNV | Missense_Mutation | rs773754223 | c.647N>A | p.Arg216Gln | p.R216Q | Q9HD33 | protein_coding | tolerated(0.36) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| MRPL47 | SNV | Missense_Mutation | novel | c.575A>G | p.Lys192Arg | p.K192R | Q9HD33 | protein_coding | tolerated(0.27) | benign(0.036) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| MRPL47 | SNV | Missense_Mutation | novel | c.602N>T | p.Ala201Val | p.A201V | Q9HD33 | protein_coding | tolerated(0.46) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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