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Gene: MRPL41 |
Gene summary for MRPL41 |
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Gene information | Species | Human | Gene symbol | MRPL41 | Gene ID | 64975 |
Gene name | mitochondrial ribosomal protein L41 | |
Gene Alias | BMRP | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q8IXM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64975 | MRPL41 | GSM4909287 | Human | Breast | IDC | 4.21e-03 | -2.60e-01 | 0.2057 |
64975 | MRPL41 | GSM4909290 | Human | Breast | IDC | 2.79e-14 | 5.41e-01 | 0.2096 |
64975 | MRPL41 | GSM4909291 | Human | Breast | IDC | 9.82e-08 | 4.38e-01 | 0.1753 |
64975 | MRPL41 | GSM4909293 | Human | Breast | IDC | 2.75e-20 | 5.30e-01 | 0.1581 |
64975 | MRPL41 | GSM4909294 | Human | Breast | IDC | 6.65e-22 | 4.96e-01 | 0.2022 |
64975 | MRPL41 | GSM4909296 | Human | Breast | IDC | 2.77e-08 | 1.94e-01 | 0.1524 |
64975 | MRPL41 | GSM4909297 | Human | Breast | IDC | 2.52e-10 | -1.80e-01 | 0.1517 |
64975 | MRPL41 | GSM4909301 | Human | Breast | IDC | 7.77e-10 | 3.50e-01 | 0.1577 |
64975 | MRPL41 | GSM4909306 | Human | Breast | IDC | 1.58e-03 | 3.38e-01 | 0.1564 |
64975 | MRPL41 | GSM4909308 | Human | Breast | IDC | 2.99e-04 | 3.33e-01 | 0.158 |
64975 | MRPL41 | GSM4909311 | Human | Breast | IDC | 1.50e-28 | -2.08e-01 | 0.1534 |
64975 | MRPL41 | GSM4909312 | Human | Breast | IDC | 3.13e-10 | -1.25e-01 | 0.1552 |
64975 | MRPL41 | GSM4909313 | Human | Breast | IDC | 4.46e-04 | 8.76e-02 | 0.0391 |
64975 | MRPL41 | GSM4909315 | Human | Breast | IDC | 7.58e-06 | 3.76e-01 | 0.21 |
64975 | MRPL41 | GSM4909316 | Human | Breast | IDC | 3.68e-09 | 4.11e-01 | 0.21 |
64975 | MRPL41 | GSM4909319 | Human | Breast | IDC | 1.44e-35 | -3.48e-01 | 0.1563 |
64975 | MRPL41 | GSM4909320 | Human | Breast | IDC | 1.05e-06 | -2.24e-01 | 0.1575 |
64975 | MRPL41 | GSM4909321 | Human | Breast | IDC | 3.19e-14 | -7.75e-02 | 0.1559 |
64975 | MRPL41 | brca2 | Human | Breast | Precancer | 1.25e-04 | 2.30e-01 | -0.024 |
64975 | MRPL41 | NCCBC14 | Human | Breast | DCIS | 1.21e-10 | 2.44e-02 | 0.2021 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL41 | insertion | In_Frame_Ins | novel | c.250_251insGAG | p.Thr84delinsArgAla | p.T84delinsRA | Q8IXM3 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
MRPL41 | SNV | Missense_Mutation | rs376218719 | c.156G>T | p.Gln52His | p.Q52H | Q8IXM3 | protein_coding | tolerated(0.12) | possibly_damaging(0.67) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL41 | SNV | Missense_Mutation | novel | c.352N>T | p.Gly118Cys | p.G118C | Q8IXM3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MRPL41 | SNV | Missense_Mutation | c.207N>T | p.Lys69Asn | p.K69N | Q8IXM3 | protein_coding | tolerated(0.08) | benign(0.045) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL41 | SNV | Missense_Mutation | rs773179110 | c.169N>A | p.Val57Ile | p.V57I | Q8IXM3 | protein_coding | tolerated(1) | benign(0.047) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL41 | SNV | Missense_Mutation | novel | c.296N>T | p.Ala99Val | p.A99V | Q8IXM3 | protein_coding | deleterious(0.02) | benign(0.412) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL41 | SNV | Missense_Mutation | c.307N>T | p.Asp103Tyr | p.D103Y | Q8IXM3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
MRPL41 | SNV | Missense_Mutation | novel | c.275N>G | p.Phe92Cys | p.F92C | Q8IXM3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BA-6868-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
MRPL41 | SNV | Missense_Mutation | novel | c.358N>C | p.Glu120Gln | p.E120Q | Q8IXM3 | protein_coding | tolerated(0.06) | probably_damaging(0.979) | TCGA-CV-7427-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MRPL41 | SNV | Missense_Mutation | rs773179110 | c.169G>A | p.Val57Ile | p.V57I | Q8IXM3 | protein_coding | tolerated(1) | benign(0.047) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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