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Gene: MRPL19 |
Gene summary for MRPL19 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MRPL19 | Gene ID | 9801 |
| Gene name | mitochondrial ribosomal protein L19 | |
| Gene Alias | L19mt | |
| Cytomap | 2p12 | |
| Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | P49406 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9801 | MRPL19 | LZE2T | Human | Esophagus | ESCC | 9.47e-04 | 7.72e-01 | 0.082 |
| 9801 | MRPL19 | LZE4T | Human | Esophagus | ESCC | 2.35e-13 | 5.24e-01 | 0.0811 |
| 9801 | MRPL19 | LZE5T | Human | Esophagus | ESCC | 4.23e-09 | 5.95e-01 | 0.0514 |
| 9801 | MRPL19 | LZE7T | Human | Esophagus | ESCC | 6.35e-08 | 5.12e-01 | 0.0667 |
| 9801 | MRPL19 | LZE8T | Human | Esophagus | ESCC | 4.54e-09 | 3.04e-01 | 0.067 |
| 9801 | MRPL19 | LZE20T | Human | Esophagus | ESCC | 3.14e-03 | 1.19e-01 | 0.0662 |
| 9801 | MRPL19 | LZE22D1 | Human | Esophagus | HGIN | 6.74e-03 | 1.71e-01 | 0.0595 |
| 9801 | MRPL19 | LZE22T | Human | Esophagus | ESCC | 1.53e-03 | 3.69e-01 | 0.068 |
| 9801 | MRPL19 | LZE24T | Human | Esophagus | ESCC | 4.91e-18 | 5.13e-01 | 0.0596 |
| 9801 | MRPL19 | LZE6T | Human | Esophagus | ESCC | 2.88e-10 | 5.75e-01 | 0.0845 |
| 9801 | MRPL19 | P1T-E | Human | Esophagus | ESCC | 3.79e-11 | 4.93e-01 | 0.0875 |
| 9801 | MRPL19 | P2T-E | Human | Esophagus | ESCC | 5.48e-56 | 1.02e+00 | 0.1177 |
| 9801 | MRPL19 | P4T-E | Human | Esophagus | ESCC | 4.33e-48 | 1.13e+00 | 0.1323 |
| 9801 | MRPL19 | P5T-E | Human | Esophagus | ESCC | 2.96e-36 | 6.98e-01 | 0.1327 |
| 9801 | MRPL19 | P8T-E | Human | Esophagus | ESCC | 5.52e-21 | 5.00e-01 | 0.0889 |
| 9801 | MRPL19 | P9T-E | Human | Esophagus | ESCC | 1.96e-22 | 5.20e-01 | 0.1131 |
| 9801 | MRPL19 | P10T-E | Human | Esophagus | ESCC | 2.09e-33 | 6.61e-01 | 0.116 |
| 9801 | MRPL19 | P11T-E | Human | Esophagus | ESCC | 6.95e-23 | 8.18e-01 | 0.1426 |
| 9801 | MRPL19 | P12T-E | Human | Esophagus | ESCC | 5.23e-31 | 7.52e-01 | 0.1122 |
| 9801 | MRPL19 | P15T-E | Human | Esophagus | ESCC | 4.94e-37 | 6.95e-01 | 0.1149 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
| hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
| hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
| hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
| hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
| hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
| hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
| hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
| hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
| hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
| hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
| hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MRPL19 | SNV | Missense_Mutation | novel | c.230N>T | p.Ser77Ile | p.S77I | P49406 | protein_coding | tolerated(0.19) | probably_damaging(0.999) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
| MRPL19 | SNV | Missense_Mutation | rs753109462 | c.695G>T | p.Arg232Leu | p.R232L | P49406 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-E9-A22D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD |
| MRPL19 | SNV | Missense_Mutation | rs753109462 | c.695G>A | p.Arg232His | p.R232H | P49406 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MRPL19 | SNV | Missense_Mutation | c.301N>C | p.Glu101Gln | p.E101Q | P49406 | protein_coding | tolerated(0.83) | benign(0.013) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
| MRPL19 | SNV | Missense_Mutation | c.74N>C | p.Leu25Pro | p.L25P | P49406 | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.694) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR | |
| MRPL19 | SNV | Missense_Mutation | c.225C>A | p.Phe75Leu | p.F75L | P49406 | protein_coding | deleterious(0.02) | benign(0.198) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| MRPL19 | SNV | Missense_Mutation | c.292G>T | p.Asp98Tyr | p.D98Y | P49406 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| MRPL19 | insertion | Frame_Shift_Ins | novel | c.77_78insC | p.Pro29AlafsTer51 | p.P29Afs*51 | P49406 | protein_coding | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MRPL19 | deletion | Frame_Shift_Del | c.78delN | p.Pro28ArgfsTer49 | p.P28Rfs*49 | P49406 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| MRPL19 | deletion | Frame_Shift_Del | c.83delC | p.Pro28ArgfsTer49 | p.P28Rfs*49 | P49406 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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