Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MRPL10

Gene summary for MRPL10

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MRPL10

Gene ID

124995

Gene namemitochondrial ribosomal protein L10
Gene AliasL10MT
Cytomap17q21.32
Gene Typeprotein-coding
GO ID

GO:0006412

UniProtAcc

Q7Z7H8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
124995MRPL10HTA11_2487_2000001011HumanColorectumSER1.02e-042.84e-01-0.1808
124995MRPL10HTA11_1938_2000001011HumanColorectumAD3.41e-021.74e-01-0.0811
124995MRPL10HTA11_347_2000001011HumanColorectumAD1.78e-031.63e-01-0.1954
124995MRPL10HTA11_3361_2000001011HumanColorectumAD2.76e-032.22e-01-0.1207
124995MRPL10HTA11_696_2000001011HumanColorectumAD2.72e-032.05e-01-0.1464
124995MRPL10HTA11_1391_2000001011HumanColorectumAD6.83e-082.56e-01-0.059
124995MRPL10HTA11_7862_2000001011HumanColorectumAD1.91e-032.64e-01-0.0179
124995MRPL10HTA11_866_3004761011HumanColorectumAD2.22e-093.32e-010.096
124995MRPL10HTA11_4255_2000001011HumanColorectumSER5.10e-033.39e-010.0446
124995MRPL10HTA11_8622_2000001021HumanColorectumSER5.98e-063.42e-010.0528
124995MRPL10HTA11_7663_2000001011HumanColorectumSER4.34e-033.84e-010.0131
124995MRPL10HTA11_6801_2000001011HumanColorectumSER2.28e-023.35e-010.0171
124995MRPL10HTA11_10711_2000001011HumanColorectumAD3.28e-072.34e-010.0338
124995MRPL10HTA11_7696_3000711011HumanColorectumAD5.80e-142.98e-010.0674
124995MRPL10HTA11_6818_2000001021HumanColorectumAD1.26e-032.07e-010.0588
124995MRPL10HTA11_99999970781_79442HumanColorectumMSS7.59e-164.06e-010.294
124995MRPL10HTA11_99999965104_69814HumanColorectumMSS3.35e-083.16e-010.281
124995MRPL10HTA11_99999971662_82457HumanColorectumMSS5.34e-195.00e-010.3859
124995MRPL10HTA11_99999974143_84620HumanColorectumMSS2.50e-164.06e-010.3005
124995MRPL10LZE4THumanEsophagusESCC2.25e-153.77e-010.0811
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa03010ColorectumADRibosome96/2092167/84658.28e-205.54e-183.54e-1896
hsa030101ColorectumADRibosome96/2092167/84658.28e-205.54e-183.54e-1896
hsa030102ColorectumSERRibosome92/1580167/84652.21e-263.66e-242.66e-2492
hsa030103ColorectumSERRibosome92/1580167/84652.21e-263.66e-242.66e-2492
hsa030104ColorectumMSSRibosome96/1875167/84651.82e-232.03e-211.24e-2196
hsa030105ColorectumMSSRibosome96/1875167/84651.82e-232.03e-211.24e-2196
hsa03010211EsophagusESCCRibosome129/4205167/84651.43e-133.43e-121.75e-12129
hsa03010310EsophagusESCCRibosome129/4205167/84651.43e-133.43e-121.75e-12129
hsa0301022LiverCirrhoticRibosome127/2530167/84652.12e-357.06e-334.35e-33127
hsa0301032LiverCirrhoticRibosome127/2530167/84652.12e-357.06e-334.35e-33127
hsa0301042LiverHCCRibosome128/4020167/84657.32e-152.23e-131.24e-13128
hsa0301052LiverHCCRibosome128/4020167/84657.32e-152.23e-131.24e-13128
hsa0301030Oral cavityOSCCRibosome128/3704167/84652.42e-181.62e-168.25e-17128
hsa03010114Oral cavityOSCCRibosome128/3704167/84652.42e-181.62e-168.25e-17128
hsa03010210Oral cavityLPRibosome127/2418167/84651.22e-374.05e-352.61e-35127
hsa0301038Oral cavityLPRibosome127/2418167/84651.22e-374.05e-352.61e-35127
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MRPL10SNVMissense_Mutationrs368901192c.754N>Ap.Glu252Lysp.E252KQ7Z7H8protein_codingtolerated(0.2)benign(0.003)TCGA-MY-A5BF-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinCR
MRPL10SNVMissense_Mutationc.520N>Cp.Met174Leup.M174LQ7Z7H8protein_codingtolerated(0.36)benign(0.059)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
MRPL10SNVMissense_Mutationc.568N>Gp.Cys190Glyp.C190GQ7Z7H8protein_codingdeleterious(0.01)possibly_damaging(0.863)TCGA-AD-5900-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MRPL10SNVMissense_Mutationc.170N>Gp.Leu57Argp.L57RQ7Z7H8protein_codingdeleterious(0)probably_damaging(0.917)TCGA-A5-A0GB-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPL10SNVMissense_Mutationrs373997600c.139N>Tp.Arg47Cysp.R47CQ7Z7H8protein_codingdeleterious(0.01)possibly_damaging(0.732)TCGA-AJ-A5DW-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MRPL10SNVMissense_Mutationnovelc.230C>Ap.Ser77Tyrp.S77YQ7Z7H8protein_codingdeleterious(0)possibly_damaging(0.558)TCGA-AX-A2HC-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelPD
MRPL10SNVMissense_Mutationc.151C>Tp.His51Tyrp.H51YQ7Z7H8protein_codingdeleterious(0)probably_damaging(0.943)TCGA-BG-A0M0-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPL10SNVMissense_Mutationrs781472477c.752N>Ap.Arg251Hisp.R251HQ7Z7H8protein_codingtolerated(0.42)benign(0)TCGA-D1-A0ZO-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPL10SNVMissense_Mutationc.553C>Tp.Pro185Serp.P185SQ7Z7H8protein_codingtolerated(0.82)benign(0.009)TCGA-D1-A15X-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MRPL10SNVMissense_Mutationrs369022041c.278N>Ap.Arg93Hisp.R93HQ7Z7H8protein_codingtolerated(0.22)benign(0.028)TCGA-D1-A1O7-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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