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Gene: MROH7 |
Gene summary for MROH7 |
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Gene information | Species | Human | Gene symbol | MROH7 | Gene ID | 374977 |
Gene name | maestro heat like repeat family member 7 | |
Gene Alias | C1orf175 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z7S6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374977 | MROH7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.06e-10 | 2.37e-01 | 0.0155 |
374977 | MROH7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.17e-11 | 3.08e-01 | -0.1808 |
374977 | MROH7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.80e-01 | 0.0216 |
374977 | MROH7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.73e-09 | 2.98e-01 | -0.0811 |
374977 | MROH7 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.17e-12 | 4.23e-01 | -0.1088 |
374977 | MROH7 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.93e-42 | 8.09e-01 | -0.1954 |
374977 | MROH7 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 4.38e-01 | -0.2602 |
374977 | MROH7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.93e-12 | 3.89e-01 | -0.1207 |
374977 | MROH7 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.60e-14 | 4.76e-01 | -0.1526 |
374977 | MROH7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.84e-22 | 4.41e-01 | -0.1464 |
374977 | MROH7 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.28e-38 | 6.14e-01 | -0.1001 |
374977 | MROH7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.74e-32 | 7.54e-01 | -0.059 |
374977 | MROH7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.63e-01 | -0.1706 |
374977 | MROH7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.03e-03 | 2.37e-01 | -0.2061 |
374977 | MROH7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 3.08e-01 | -0.1462 |
374977 | MROH7 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.21e-19 | 6.14e-01 | -0.0842 |
374977 | MROH7 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.01e-04 | 3.68e-01 | -0.00410000000000005 |
374977 | MROH7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 3.39e-01 | -0.0179 |
374977 | MROH7 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-10 | 2.55e-01 | 0.096 |
374977 | MROH7 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.89e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MROH7 | SNV | Missense_Mutation | c.3873C>A | p.His1291Gln | p.H1291Q | Q68CQ1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
MROH7 | SNV | Missense_Mutation | c.2804N>C | p.Met935Thr | p.M935T | Q68CQ1 | protein_coding | deleterious(0) | benign(0.215) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MROH7 | SNV | Missense_Mutation | rs778801607 | c.3215N>A | p.Arg1072Gln | p.R1072Q | Q68CQ1 | protein_coding | tolerated(1) | benign(0) | TCGA-AR-A24S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
MROH7 | SNV | Missense_Mutation | c.491N>T | p.Gly164Val | p.G164V | Q68CQ1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-B6-A0RP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MROH7 | SNV | Missense_Mutation | c.1621G>A | p.Glu541Lys | p.E541K | Q68CQ1 | protein_coding | tolerated(0.07) | benign(0.022) | TCGA-C8-A8HR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
MROH7 | SNV | Missense_Mutation | c.2707N>C | p.Val903Leu | p.V903L | Q68CQ1 | protein_coding | tolerated(0.45) | possibly_damaging(0.875) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MROH7 | SNV | Missense_Mutation | rs554316180 | c.2101N>A | p.Ala701Thr | p.A701T | Q68CQ1 | protein_coding | tolerated(0.21) | probably_damaging(0.973) | TCGA-EW-A3E8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
MROH7 | insertion | Frame_Shift_Ins | novel | c.2931_2932insACTTCTTTTTTGAGATGGAGTCT | p.His978ThrfsTer42 | p.H978Tfs*42 | Q68CQ1 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
MROH7 | SNV | Missense_Mutation | novel | c.3839N>A | p.Gly1280Glu | p.G1280E | Q68CQ1 | protein_coding | tolerated(0.07) | possibly_damaging(0.463) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
MROH7 | SNV | Missense_Mutation | rs368938972 | c.2570N>A | p.Arg857His | p.R857H | Q68CQ1 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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