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Gene: MRGPRF |
Gene summary for MRGPRF |
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Gene information | Species | Human | Gene symbol | MRGPRF | Gene ID | 116535 |
Gene name | MAS related GPR family member F | |
Gene Alias | GPR140 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024R5F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116535 | MRGPRF | S014 | Human | Liver | HCC | 4.71e-09 | 5.79e-01 | 0.2254 |
116535 | MRGPRF | S015 | Human | Liver | HCC | 1.78e-23 | 1.06e+00 | 0.2375 |
116535 | MRGPRF | S016 | Human | Liver | HCC | 3.70e-26 | 9.30e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRGPRF | SNV | Missense_Mutation | novel | c.890N>C | p.Asp297Ala | p.D297A | Q96AM1 | protein_coding | tolerated(0.21) | possibly_damaging(0.888) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
MRGPRF | SNV | Missense_Mutation | c.67G>A | p.Glu23Lys | p.E23K | Q96AM1 | protein_coding | deleterious(0.02) | probably_damaging(0.972) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MRGPRF | SNV | Missense_Mutation | novel | c.218N>G | p.Ile73Ser | p.I73S | Q96AM1 | protein_coding | deleterious(0.03) | benign(0.078) | TCGA-C8-A3M8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
MRGPRF | SNV | Missense_Mutation | c.673G>A | p.Glu225Lys | p.E225K | Q96AM1 | protein_coding | tolerated(0.23) | benign(0.426) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MRGPRF | SNV | Missense_Mutation | c.464N>T | p.Arg155Leu | p.R155L | Q96AM1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRGPRF | SNV | Missense_Mutation | c.326N>A | p.Gly109Asp | p.G109D | Q96AM1 | protein_coding | tolerated(0.14) | probably_damaging(0.913) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
MRGPRF | SNV | Missense_Mutation | rs754875925 | c.418G>A | p.Glu140Lys | p.E140K | Q96AM1 | protein_coding | deleterious(0.01) | probably_damaging(0.952) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRGPRF | SNV | Missense_Mutation | c.234N>A | p.Phe78Leu | p.F78L | Q96AM1 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRGPRF | SNV | Missense_Mutation | c.575C>T | p.Ala192Val | p.A192V | Q96AM1 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
MRGPRF | SNV | Missense_Mutation | novel | c.458N>A | p.Arg153His | p.R153H | Q96AM1 | protein_coding | tolerated(0.55) | benign(0.007) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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