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Gene: MRFAP1L1 |
Gene summary for MRFAP1L1 |
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Gene information | Species | Human | Gene symbol | MRFAP1L1 | Gene ID | 114932 |
Gene name | Morf4 family associated protein 1 like 1 | |
Gene Alias | PP784 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A075DDR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114932 | MRFAP1L1 | LZE4T | Human | Esophagus | ESCC | 4.70e-07 | 1.38e-01 | 0.0811 |
114932 | MRFAP1L1 | LZE5T | Human | Esophagus | ESCC | 7.26e-06 | 6.41e-01 | 0.0514 |
114932 | MRFAP1L1 | LZE7T | Human | Esophagus | ESCC | 2.49e-10 | 4.39e-01 | 0.0667 |
114932 | MRFAP1L1 | LZE8T | Human | Esophagus | ESCC | 6.56e-10 | 2.55e-01 | 0.067 |
114932 | MRFAP1L1 | LZE20T | Human | Esophagus | ESCC | 3.17e-08 | 4.63e-01 | 0.0662 |
114932 | MRFAP1L1 | LZE22D1 | Human | Esophagus | HGIN | 2.18e-03 | -1.43e-02 | 0.0595 |
114932 | MRFAP1L1 | LZE22T | Human | Esophagus | ESCC | 2.71e-04 | 2.57e-01 | 0.068 |
114932 | MRFAP1L1 | LZE24T | Human | Esophagus | ESCC | 1.39e-14 | 5.08e-01 | 0.0596 |
114932 | MRFAP1L1 | LZE21T | Human | Esophagus | ESCC | 1.37e-02 | -7.61e-02 | 0.0655 |
114932 | MRFAP1L1 | LZE6T | Human | Esophagus | ESCC | 1.51e-07 | 3.57e-01 | 0.0845 |
114932 | MRFAP1L1 | P1T-E | Human | Esophagus | ESCC | 1.12e-04 | 2.14e-01 | 0.0875 |
114932 | MRFAP1L1 | P2T-E | Human | Esophagus | ESCC | 8.12e-37 | 7.97e-01 | 0.1177 |
114932 | MRFAP1L1 | P4T-E | Human | Esophagus | ESCC | 7.24e-19 | 4.94e-01 | 0.1323 |
114932 | MRFAP1L1 | P5T-E | Human | Esophagus | ESCC | 3.79e-11 | 1.59e-01 | 0.1327 |
114932 | MRFAP1L1 | P8T-E | Human | Esophagus | ESCC | 2.56e-32 | 6.62e-01 | 0.0889 |
114932 | MRFAP1L1 | P9T-E | Human | Esophagus | ESCC | 4.75e-17 | 2.88e-01 | 0.1131 |
114932 | MRFAP1L1 | P10T-E | Human | Esophagus | ESCC | 9.97e-29 | 5.79e-01 | 0.116 |
114932 | MRFAP1L1 | P11T-E | Human | Esophagus | ESCC | 1.80e-19 | 9.36e-01 | 0.1426 |
114932 | MRFAP1L1 | P12T-E | Human | Esophagus | ESCC | 8.52e-32 | 6.99e-01 | 0.1122 |
114932 | MRFAP1L1 | P15T-E | Human | Esophagus | ESCC | 4.02e-16 | 3.53e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRFAP1L1 | SNV | Missense_Mutation | c.133N>A | p.Glu45Lys | p.E45K | Q96HT8 | protein_coding | tolerated(0.13) | benign(0.026) | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
MRFAP1L1 | insertion | Frame_Shift_Ins | novel | c.85_86insAG | p.Leu29GlnfsTer94 | p.L29Qfs*94 | Q96HT8 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRFAP1L1 | insertion | Nonsense_Mutation | novel | c.84_85insTCTTCATGGTAAATTTCTCCCAATTGTGCTTTAGGTTCA | p.Leu28_Leu29insSerSerTrpTerIleSerProAsnCysAlaLeuGlySer | p.L28_L29insSSW*ISPNCALGS | Q96HT8 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRFAP1L1 | SNV | Missense_Mutation | rs778160804 | c.4N>T | p.Arg2Trp | p.R2W | Q96HT8 | protein_coding | tolerated(0.1) | possibly_damaging(0.861) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MRFAP1L1 | SNV | Missense_Mutation | rs759990042 | c.289T>C | p.Cys97Arg | p.C97R | Q96HT8 | protein_coding | deleterious(0.01) | benign(0.196) | TCGA-DM-A1D6-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MRFAP1L1 | SNV | Missense_Mutation | c.81N>A | p.Phe27Leu | p.F27L | Q96HT8 | protein_coding | tolerated(0.31) | possibly_damaging(0.453) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
MRFAP1L1 | SNV | Missense_Mutation | novel | c.124N>A | p.Leu42Ile | p.L42I | Q96HT8 | protein_coding | deleterious(0.05) | possibly_damaging(0.616) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRFAP1L1 | SNV | Missense_Mutation | c.164G>T | p.Ser55Ile | p.S55I | Q96HT8 | protein_coding | tolerated(0.09) | possibly_damaging(0.625) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRFAP1L1 | SNV | Missense_Mutation | novel | c.348N>T | p.Glu116Asp | p.E116D | Q96HT8 | protein_coding | deleterious(0.04) | benign(0.081) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MRFAP1L1 | SNV | Missense_Mutation | novel | c.34N>T | p.Pro12Ser | p.P12S | Q96HT8 | protein_coding | tolerated(0.09) | probably_damaging(0.996) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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