![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MPPE1 |
Gene summary for MPPE1 |
![]() |
Gene information | Species | Human | Gene symbol | MPPE1 | Gene ID | 65258 |
Gene name | metallophosphoesterase 1 | |
Gene Alias | Cdc1 | |
Cytomap | 18p11.21 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q53F39 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65258 | MPPE1 | LZE4T | Human | Esophagus | ESCC | 6.88e-09 | 2.45e-01 | 0.0811 |
65258 | MPPE1 | LZE7T | Human | Esophagus | ESCC | 2.42e-07 | 3.29e-01 | 0.0667 |
65258 | MPPE1 | LZE8T | Human | Esophagus | ESCC | 2.03e-04 | 2.22e-01 | 0.067 |
65258 | MPPE1 | LZE20T | Human | Esophagus | ESCC | 5.73e-04 | 1.32e-01 | 0.0662 |
65258 | MPPE1 | LZE22T | Human | Esophagus | ESCC | 6.14e-04 | 1.98e-01 | 0.068 |
65258 | MPPE1 | LZE24T | Human | Esophagus | ESCC | 2.35e-16 | 3.61e-01 | 0.0596 |
65258 | MPPE1 | LZE21T | Human | Esophagus | ESCC | 1.02e-03 | 2.90e-01 | 0.0655 |
65258 | MPPE1 | LZE6T | Human | Esophagus | ESCC | 1.01e-03 | 1.50e-01 | 0.0845 |
65258 | MPPE1 | P1T-E | Human | Esophagus | ESCC | 1.77e-07 | 3.28e-01 | 0.0875 |
65258 | MPPE1 | P2T-E | Human | Esophagus | ESCC | 8.41e-26 | 4.32e-01 | 0.1177 |
65258 | MPPE1 | P4T-E | Human | Esophagus | ESCC | 1.05e-24 | 4.38e-01 | 0.1323 |
65258 | MPPE1 | P5T-E | Human | Esophagus | ESCC | 2.89e-24 | 4.41e-01 | 0.1327 |
65258 | MPPE1 | P8T-E | Human | Esophagus | ESCC | 1.35e-22 | 4.40e-01 | 0.0889 |
65258 | MPPE1 | P9T-E | Human | Esophagus | ESCC | 7.49e-25 | 4.30e-01 | 0.1131 |
65258 | MPPE1 | P10T-E | Human | Esophagus | ESCC | 2.53e-22 | 3.21e-01 | 0.116 |
65258 | MPPE1 | P11T-E | Human | Esophagus | ESCC | 9.52e-15 | 5.20e-01 | 0.1426 |
65258 | MPPE1 | P12T-E | Human | Esophagus | ESCC | 1.15e-15 | 2.49e-01 | 0.1122 |
65258 | MPPE1 | P15T-E | Human | Esophagus | ESCC | 1.51e-18 | 3.85e-01 | 0.1149 |
65258 | MPPE1 | P16T-E | Human | Esophagus | ESCC | 3.25e-21 | 2.95e-01 | 0.1153 |
65258 | MPPE1 | P17T-E | Human | Esophagus | ESCC | 5.47e-05 | 2.61e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00464673 | Esophagus | ESCC | membrane lipid biosynthetic process | 91/8552 | 142/18723 | 7.19e-06 | 7.19e-05 | 91 |
GO:00421573 | Esophagus | ESCC | lipoprotein metabolic process | 86/8552 | 135/18723 | 1.78e-05 | 1.57e-04 | 86 |
GO:00064973 | Esophagus | ESCC | protein lipidation | 62/8552 | 92/18723 | 2.08e-05 | 1.80e-04 | 62 |
GO:00421583 | Esophagus | ESCC | lipoprotein biosynthetic process | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00065063 | Esophagus | ESCC | GPI anchor biosynthetic process | 26/8552 | 32/18723 | 3.97e-05 | 3.21e-04 | 26 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00065053 | Esophagus | ESCC | GPI anchor metabolic process | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:00066642 | Esophagus | ESCC | glycolipid metabolic process | 63/8552 | 100/18723 | 3.55e-04 | 2.06e-03 | 63 |
GO:19035092 | Esophagus | ESCC | liposaccharide metabolic process | 63/8552 | 101/18723 | 5.25e-04 | 2.90e-03 | 63 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:0009247 | Esophagus | ESCC | glycolipid biosynthetic process | 42/8552 | 68/18723 | 5.48e-03 | 2.05e-02 | 42 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa005632 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa0056311 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa00563 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
hsa005631 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPPE1 | insertion | In_Frame_Ins | novel | c.932_933insGACTTATTCCCTCCTATTAGAACATATCCC | p.His311delinsGlnThrTyrSerLeuLeuLeuGluHisIlePro | p.H311delinsQTYSLLLEHIP | Q53F39 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
MPPE1 | insertion | Nonsense_Mutation | novel | c.1140_1141insACCACGCCTGGCTAATTTTTGTATTT | p.Ser381ThrfsTer5 | p.S381Tfs*5 | Q53F39 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MPPE1 | SNV | Missense_Mutation | c.475N>C | p.Asp159His | p.D159H | Q53F39 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
MPPE1 | SNV | Missense_Mutation | novel | c.1085G>A | p.Cys362Tyr | p.C362Y | Q53F39 | protein_coding | deleterious(0.02) | benign(0.405) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MPPE1 | SNV | Missense_Mutation | novel | c.1030N>C | p.Tyr344His | p.Y344H | Q53F39 | protein_coding | tolerated(0.12) | benign(0.285) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MPPE1 | SNV | Missense_Mutation | rs749515863 | c.1058N>A | p.Arg353His | p.R353H | Q53F39 | protein_coding | tolerated(0.54) | benign(0.009) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MPPE1 | SNV | Missense_Mutation | rs536672004 | c.917G>A | p.Ser306Asn | p.S306N | Q53F39 | protein_coding | tolerated(0.49) | benign(0.102) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MPPE1 | SNV | Missense_Mutation | rs758771933 | c.1088N>A | p.Gly363Glu | p.G363E | Q53F39 | protein_coding | tolerated(0.11) | benign(0.081) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MPPE1 | SNV | Missense_Mutation | rs369348336 | c.197N>A | p.Arg66His | p.R66H | Q53F39 | protein_coding | tolerated(0.2) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MPPE1 | SNV | Missense_Mutation | novel | c.761N>A | p.Arg254Gln | p.R254Q | Q53F39 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |