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Gene: MPLKIP |
Gene summary for MPLKIP |
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Gene information | Species | Human | Gene symbol | MPLKIP | Gene ID | 136647 |
Gene name | M-phase specific PLK1 interacting protein | |
Gene Alias | ABHS | |
Cytomap | 7p14.1 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | A4D1W6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
136647 | MPLKIP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.25e-14 | 3.28e-01 | -0.1954 |
136647 | MPLKIP | HTA11_696_2000001011 | Human | Colorectum | AD | 4.13e-04 | 1.72e-01 | -0.1464 |
136647 | MPLKIP | HTA11_866_2000001011 | Human | Colorectum | AD | 9.03e-05 | 1.49e-01 | -0.1001 |
136647 | MPLKIP | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.85e-07 | 2.66e-01 | -0.059 |
136647 | MPLKIP | HTA11_866_3004761011 | Human | Colorectum | AD | 1.30e-05 | 2.39e-01 | 0.096 |
136647 | MPLKIP | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.94e-05 | 2.02e-01 | 0.0674 |
136647 | MPLKIP | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.45e-02 | 2.17e-01 | 0.0588 |
136647 | MPLKIP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.95e-11 | 3.18e-01 | 0.294 |
136647 | MPLKIP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.53e-02 | 2.08e-01 | 0.281 |
136647 | MPLKIP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.80e-19 | 4.43e-01 | 0.3859 |
136647 | MPLKIP | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.26e-06 | 3.76e-01 | 0.2585 |
136647 | MPLKIP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.56e-11 | 3.36e-01 | 0.3005 |
136647 | MPLKIP | LZE2T | Human | Esophagus | ESCC | 1.34e-02 | 9.49e-01 | 0.082 |
136647 | MPLKIP | LZE4T | Human | Esophagus | ESCC | 5.62e-17 | 7.58e-01 | 0.0811 |
136647 | MPLKIP | LZE5T | Human | Esophagus | ESCC | 5.48e-04 | 6.04e-01 | 0.0514 |
136647 | MPLKIP | LZE7T | Human | Esophagus | ESCC | 4.95e-12 | 8.28e-01 | 0.0667 |
136647 | MPLKIP | LZE8T | Human | Esophagus | ESCC | 1.74e-10 | 4.46e-01 | 0.067 |
136647 | MPLKIP | LZE20T | Human | Esophagus | ESCC | 2.01e-12 | 4.37e-01 | 0.0662 |
136647 | MPLKIP | LZE22D1 | Human | Esophagus | HGIN | 1.15e-04 | 2.13e-01 | 0.0595 |
136647 | MPLKIP | LZE24D1 | Human | Esophagus | HGIN | 1.89e-02 | 4.65e-01 | 0.054 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPLKIP | SNV | Missense_Mutation | c.482N>C | p.Ser161Thr | p.S161T | Q8TAP9 | protein_coding | tolerated(0.19) | benign(0.022) | TCGA-E2-A14R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
MPLKIP | SNV | Missense_Mutation | rs748305028 | c.377N>A | p.Arg126His | p.R126H | Q8TAP9 | protein_coding | tolerated(0.89) | benign(0.003) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MPLKIP | SNV | Missense_Mutation | c.392N>T | p.Arg131Ile | p.R131I | Q8TAP9 | protein_coding | deleterious(0) | benign(0.407) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MPLKIP | deletion | Frame_Shift_Del | c.314delC | p.Pro105GlnfsTer48 | p.P105Qfs*48 | Q8TAP9 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
MPLKIP | SNV | Missense_Mutation | rs758376152 | c.376N>T | p.Arg126Cys | p.R126C | Q8TAP9 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MPLKIP | SNV | Missense_Mutation | novel | c.415N>G | p.Tyr139Asp | p.Y139D | Q8TAP9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
MPLKIP | SNV | Missense_Mutation | novel | c.443C>A | p.Pro148His | p.P148H | Q8TAP9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MPLKIP | deletion | Frame_Shift_Del | novel | c.522delA | p.Gly175GlufsTer69 | p.G175Efs*69 | Q8TAP9 | protein_coding | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | ||
MPLKIP | SNV | Missense_Mutation | c.368G>A | p.Gly123Glu | p.G123E | Q8TAP9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
MPLKIP | SNV | Missense_Mutation | novel | c.401N>G | p.Asn134Ser | p.N134S | Q8TAP9 | protein_coding | deleterious(0.01) | possibly_damaging(0.702) | TCGA-56-7223-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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