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Gene: MPHOSPH8 |
Gene summary for MPHOSPH8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MPHOSPH8 | Gene ID | 54737 |
| Gene name | M-phase phosphoprotein 8 | |
| Gene Alias | HSMPP8 | |
| Cytomap | 13q12.11 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q99549 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54737 | MPHOSPH8 | CA_HPV_1 | Human | Cervix | CC | 3.31e-10 | -2.31e-01 | 0.0264 |
| 54737 | MPHOSPH8 | Tumor | Human | Cervix | CC | 4.65e-22 | -5.43e-01 | 0.1241 |
| 54737 | MPHOSPH8 | sample3 | Human | Cervix | CC | 3.42e-12 | -4.85e-01 | 0.1387 |
| 54737 | MPHOSPH8 | L1 | Human | Cervix | CC | 6.89e-05 | -3.46e-01 | 0.0802 |
| 54737 | MPHOSPH8 | T3 | Human | Cervix | CC | 3.30e-13 | -5.23e-01 | 0.1389 |
| 54737 | MPHOSPH8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.02e-02 | -1.06e-01 | 0.0155 |
| 54737 | MPHOSPH8 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.99e-20 | 7.92e-01 | -0.1954 |
| 54737 | MPHOSPH8 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.68e-06 | 4.29e-01 | -0.1464 |
| 54737 | MPHOSPH8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.35e-04 | 5.08e-01 | -0.059 |
| 54737 | MPHOSPH8 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.53e-03 | 9.49e-01 | 0.3487 |
| 54737 | MPHOSPH8 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.86e-26 | 1.38e+00 | 0.281 |
| 54737 | MPHOSPH8 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.21e-27 | 1.23e+00 | 0.3859 |
| 54737 | MPHOSPH8 | A015-C-203 | Human | Colorectum | FAP | 5.56e-20 | 1.42e-01 | -0.1294 |
| 54737 | MPHOSPH8 | A002-C-201 | Human | Colorectum | FAP | 3.21e-06 | -5.55e-02 | 0.0324 |
| 54737 | MPHOSPH8 | A002-C-203 | Human | Colorectum | FAP | 9.53e-03 | 8.04e-02 | 0.2786 |
| 54737 | MPHOSPH8 | A001-C-119 | Human | Colorectum | FAP | 7.91e-10 | 5.44e-01 | -0.1557 |
| 54737 | MPHOSPH8 | A001-C-108 | Human | Colorectum | FAP | 3.63e-15 | 4.07e-01 | -0.0272 |
| 54737 | MPHOSPH8 | A002-C-205 | Human | Colorectum | FAP | 3.27e-24 | 5.18e-01 | -0.1236 |
| 54737 | MPHOSPH8 | A001-C-104 | Human | Colorectum | FAP | 1.56e-05 | 3.31e-01 | 0.0184 |
| 54737 | MPHOSPH8 | A015-C-006 | Human | Colorectum | FAP | 6.15e-20 | 5.72e-01 | -0.0994 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
| GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
| GO:001907910 | Cervix | CC | viral genome replication | 35/2311 | 131/18723 | 6.11e-06 | 1.49e-04 | 35 |
| GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
| GO:005079210 | Cervix | CC | regulation of viral process | 38/2311 | 164/18723 | 8.12e-05 | 1.10e-03 | 38 |
| GO:190390010 | Cervix | CC | regulation of viral life cycle | 33/2311 | 148/18723 | 4.86e-04 | 4.76e-03 | 33 |
| GO:00485256 | Cervix | CC | negative regulation of viral process | 23/2311 | 92/18723 | 6.39e-04 | 5.97e-03 | 23 |
| GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
| GO:00450698 | Cervix | CC | regulation of viral genome replication | 21/2311 | 85/18723 | 1.27e-03 | 1.01e-02 | 21 |
| GO:00450714 | Cervix | CC | negative regulation of viral genome replication | 15/2311 | 56/18723 | 2.60e-03 | 1.80e-02 | 15 |
| GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
| GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
| GO:0050792 | Colorectum | AD | regulation of viral process | 59/3918 | 164/18723 | 5.95e-06 | 1.52e-04 | 59 |
| GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
| GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
| GO:1903900 | Colorectum | AD | regulation of viral life cycle | 51/3918 | 148/18723 | 9.01e-05 | 1.38e-03 | 51 |
| GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
| GO:0045069 | Colorectum | AD | regulation of viral genome replication | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MPHOSPH8 | SNV | Missense_Mutation | c.1802N>T | p.Gly601Val | p.G601V | Q99549 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
| MPHOSPH8 | SNV | Missense_Mutation | c.718N>T | p.Thr240Ser | p.T240S | Q99549 | protein_coding | tolerated_low_confidence(0.17) | benign(0.057) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| MPHOSPH8 | SNV | Missense_Mutation | c.1691N>A | p.Ala564Glu | p.A564E | Q99549 | protein_coding | tolerated(0.44) | benign(0.015) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| MPHOSPH8 | SNV | Missense_Mutation | novel | c.742N>A | p.Glu248Lys | p.E248K | Q99549 | protein_coding | deleterious_low_confidence(0) | benign(0.033) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| MPHOSPH8 | SNV | Missense_Mutation | c.1973C>T | p.Ala658Val | p.A658V | Q99549 | protein_coding | deleterious(0.05) | probably_damaging(0.984) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| MPHOSPH8 | SNV | Missense_Mutation | rs745974518 | c.1567N>A | p.Glu523Lys | p.E523K | Q99549 | protein_coding | tolerated(0.13) | benign(0.046) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| MPHOSPH8 | SNV | Missense_Mutation | c.2062G>C | p.Glu688Gln | p.E688Q | Q99549 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| MPHOSPH8 | SNV | Missense_Mutation | novel | c.625N>A | p.Glu209Lys | p.E209K | Q99549 | protein_coding | deleterious_low_confidence(0) | benign(0.03) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| MPHOSPH8 | SNV | Missense_Mutation | novel | c.2281N>C | p.Asp761His | p.D761H | Q99549 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| MPHOSPH8 | SNV | Missense_Mutation | novel | c.1927G>C | p.Glu643Gln | p.E643Q | Q99549 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 54737 | MPHOSPH8 | NA | SB-224289 | SB-224289 | ||
| 54737 | MPHOSPH8 | NA | BAY-11-7085 | BAY-11-7085 | ||
| 54737 | MPHOSPH8 | NA | PROCHLORPERAZINE | PROCHLORPERAZINE | ||
| 54737 | MPHOSPH8 | NA | NORDIHYDROGUAIARETIC ACID | NORDIHYDROGUAIARETIC ACID | ||
| 54737 | MPHOSPH8 | NA | TYRPHOSTIN AG 879 | TYRPHOSTIN AG 879 | ||
| 54737 | MPHOSPH8 | NA | EBSELEN | EBSELEN | ||
| 54737 | MPHOSPH8 | NA | INDIRUBIN SULFATE | SU-9516 | ||
| 54737 | MPHOSPH8 | NA | BENSERAZIDE HYDROCHLORIDE | BENSERAZIDE HYDROCHLORIDE | ||
| 54737 | MPHOSPH8 | NA | TAMOXIFEN CITRATE | TAMOXIFEN CITRATE | ||
| 54737 | MPHOSPH8 | NA | PICEATANNOL | PICEATANNOL |
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