Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MPC1

Gene summary for MPC1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MPC1

Gene ID

51660

Gene namemitochondrial pyruvate carrier 1
Gene AliasBRP44L
Cytomap6q27
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

Q5TI65


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51660MPC1HTA11_347_2000001011HumanColorectumAD1.19e-187.14e-01-0.1954
51660MPC1HTA11_411_2000001011HumanColorectumSER2.23e-027.24e-01-0.2602
51660MPC1HTA11_83_2000001011HumanColorectumSER8.43e-086.02e-01-0.1526
51660MPC1HTA11_5212_2000001011HumanColorectumAD8.75e-066.72e-01-0.2061
51660MPC1HTA11_99999974143_84620HumanColorectumMSS6.91e-08-3.09e-010.3005
51660MPC1A002-C-010HumanColorectumFAP4.19e-03-1.87e-010.242
51660MPC1A015-C-203HumanColorectumFAP2.09e-10-2.66e-01-0.1294
51660MPC1A002-C-201HumanColorectumFAP3.25e-05-2.83e-010.0324
51660MPC1A002-C-203HumanColorectumFAP4.02e-03-2.08e-010.2786
51660MPC1A001-C-119HumanColorectumFAP2.01e-03-3.24e-01-0.1557
51660MPC1A001-C-108HumanColorectumFAP3.33e-06-2.44e-01-0.0272
51660MPC1A002-C-205HumanColorectumFAP1.33e-09-3.51e-01-0.1236
51660MPC1A001-C-104HumanColorectumFAP3.14e-04-2.17e-010.0184
51660MPC1A015-C-005HumanColorectumFAP5.97e-03-2.80e-01-0.0336
51660MPC1A015-C-006HumanColorectumFAP2.38e-03-2.60e-01-0.0994
51660MPC1A015-C-106HumanColorectumFAP9.04e-05-1.77e-01-0.0511
51660MPC1A002-C-114HumanColorectumFAP6.23e-06-3.14e-01-0.1561
51660MPC1A015-C-104HumanColorectumFAP2.64e-13-3.10e-01-0.1899
51660MPC1A001-C-014HumanColorectumFAP1.28e-05-2.29e-010.0135
51660MPC1A002-C-016HumanColorectumFAP1.53e-13-2.68e-010.0521
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006839ColorectumADmitochondrial transport102/3918254/187231.87e-123.08e-10102
GO:1990542ColorectumADmitochondrial transmembrane transport47/3918102/187231.09e-086.52e-0747
GO:00068391ColorectumSERmitochondrial transport87/2897254/187237.91e-143.03e-1187
GO:19905421ColorectumSERmitochondrial transmembrane transport42/2897102/187233.65e-104.77e-0842
GO:00068392ColorectumMSSmitochondrial transport93/3467254/187236.14e-129.82e-1093
GO:19905422ColorectumMSSmitochondrial transmembrane transport41/3467102/187232.70e-071.11e-0541
GO:19905423ColorectumFAPmitochondrial transmembrane transport29/2622102/187231.09e-041.80e-0329
GO:00068394ColorectumFAPmitochondrial transport55/2622254/187235.58e-046.24e-0355
GO:000683920EsophagusHGINmitochondrial transport74/2587254/187231.32e-101.32e-0874
GO:199054220EsophagusHGINmitochondrial transmembrane transport29/2587102/187238.52e-051.87e-0329
GO:0006839110EsophagusESCCmitochondrial transport187/8552254/187238.35e-209.81e-18187
GO:1990542110EsophagusESCCmitochondrial transmembrane transport72/8552102/187232.94e-074.23e-0672
GO:00068397LiverCirrhoticmitochondrial transport112/4634254/187231.03e-116.66e-10112
GO:19905425LiverCirrhoticmitochondrial transmembrane transport41/4634102/187234.08e-043.37e-0341
GO:000683912LiverHCCmitochondrial transport184/7958254/187232.30e-223.83e-20184
GO:199054212LiverHCCmitochondrial transmembrane transport78/7958102/187232.73e-121.26e-1078
GO:000683918Oral cavityOSCCmitochondrial transport162/7305254/187238.96e-166.52e-14162
GO:199054218Oral cavityOSCCmitochondrial transmembrane transport56/7305102/187238.06e-044.32e-0356
GO:000683919Oral cavityLPmitochondrial transport119/4623254/187231.06e-141.33e-12119
GO:199054219Oral cavityLPmitochondrial transmembrane transport37/4623102/187235.93e-033.53e-0237
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05415ColorectumADDiabetic cardiomyopathy114/2092203/84653.65e-223.06e-201.95e-20114
hsa054151ColorectumADDiabetic cardiomyopathy114/2092203/84653.65e-223.06e-201.95e-20114
hsa054152ColorectumSERDiabetic cardiomyopathy103/1580203/84651.45e-251.61e-231.17e-23103
hsa054153ColorectumSERDiabetic cardiomyopathy103/1580203/84651.45e-251.61e-231.17e-23103
hsa054154ColorectumMSSDiabetic cardiomyopathy106/1875203/84652.47e-211.62e-199.92e-20106
hsa054155ColorectumMSSDiabetic cardiomyopathy106/1875203/84652.47e-211.62e-199.92e-20106
hsa054158ColorectumFAPDiabetic cardiomyopathy70/1404203/84652.62e-102.18e-081.33e-0870
hsa054159ColorectumFAPDiabetic cardiomyopathy70/1404203/84652.62e-102.18e-081.33e-0870
hsa0541530EsophagusHGINDiabetic cardiomyopathy80/1383203/84651.35e-153.38e-142.69e-1480
hsa05415114EsophagusHGINDiabetic cardiomyopathy80/1383203/84651.35e-153.38e-142.69e-1480
hsa05415211EsophagusESCCDiabetic cardiomyopathy146/4205203/84655.81e-117.78e-103.99e-10146
hsa0541538EsophagusESCCDiabetic cardiomyopathy146/4205203/84655.81e-117.78e-103.99e-10146
hsa0541514LiverCirrhoticDiabetic cardiomyopathy108/2530203/84651.99e-124.41e-112.72e-11108
hsa0541515LiverCirrhoticDiabetic cardiomyopathy108/2530203/84651.99e-124.41e-112.72e-11108
hsa0541522LiverHCCDiabetic cardiomyopathy151/4020203/84652.72e-151.01e-135.63e-14151
hsa0541532LiverHCCDiabetic cardiomyopathy151/4020203/84652.72e-151.01e-135.63e-14151
hsa0541529Oral cavityOSCCDiabetic cardiomyopathy131/3704203/84651.33e-091.49e-087.57e-09131
hsa05415113Oral cavityOSCCDiabetic cardiomyopathy131/3704203/84651.33e-091.49e-087.57e-09131
hsa05415210Oral cavityLPDiabetic cardiomyopathy106/2418203/84656.51e-131.36e-118.74e-12106
hsa0541537Oral cavityLPDiabetic cardiomyopathy106/2418203/84656.51e-131.36e-118.74e-12106
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MPC1SNVMissense_Mutationc.110N>Tp.Pro37Leup.P37LQ9Y5U8protein_codingdeleterious(0)probably_damaging(0.99)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
MPC1SNVMissense_Mutationrs139776186c.253N>Ap.Ala85Thrp.A85TQ9Y5U8protein_codingtolerated(0.36)benign(0.027)TCGA-E2-A15D-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
MPC1SNVMissense_Mutationc.253N>Tp.Ala85Serp.A85SQ9Y5U8protein_codingtolerated(0.46)benign(0.047)TCGA-05-4244-01Lunglung adenocarcinomaMale>=65III/IVUnknownUnknownSD
MPC1SNVMissense_Mutationrs767692880c.41N>Ap.Arg14Glnp.R14QQ9Y5U8protein_codingtolerated(0.09)benign(0.009)TCGA-CN-5374-01Oral cavityhead & neck squamous cell carcinomaFemale<65I/IIChemotherapycisplatinPD
MPC1SNVMissense_Mutationnovelc.84G>Tp.Trp28Cysp.W28CQ9Y5U8protein_codingdeleterious(0)probably_damaging(0.999)TCGA-KU-A66S-01Oral cavityhead & neck squamous cell carcinomaFemale>=65III/IVUnknownUnknownPD
MPC1insertionFrame_Shift_Insnovelc.104_105insGp.Leu36SerfsTer8p.L36Sfs*8Q9Y5U8protein_codingTCGA-UF-A71D-01Oral cavityhead & neck squamous cell carcinomaFemale<65I/IIUnknownUnknownSD
MPC1SNVMissense_Mutationrs753601697c.160N>Tp.Arg54Trpp.R54WQ9Y5U8protein_codingdeleterious(0)benign(0.112)TCGA-XK-AAIW-01Prostateprostate adenocarcinomaMale>=659UnknownUnknownPD
MPC1SNVMissense_Mutationrs387907237c.289N>Tp.Arg97Trpp.R97WQ9Y5U8protein_codingdeleterious(0.01)possibly_damaging(0.741)TCGA-VQ-AA6D-01Stomachstomach adenocarcinomaFemale<65III/IVChemotherapyfluorouracilCR
MPC1SNVMissense_Mutationrs753601697c.160N>Tp.Arg54Trpp.R54WQ9Y5U8protein_codingdeleterious(0)benign(0.112)TCGA-VQ-AA6D-01Stomachstomach adenocarcinomaFemale<65III/IVChemotherapyfluorouracilCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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