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Gene: MOSPD2 |
Gene summary for MOSPD2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MOSPD2 | Gene ID | 158747 |
Gene name | motile sperm domain containing 2 | |
Gene Alias | MOSPD2 | |
Cytomap | Xp22.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8NHP6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158747 | MOSPD2 | HCC1_Meng | Human | Liver | HCC | 3.01e-30 | 7.45e-02 | 0.0246 |
158747 | MOSPD2 | HCC2_Meng | Human | Liver | HCC | 8.54e-08 | 4.63e-02 | 0.0107 |
158747 | MOSPD2 | HCC2 | Human | Liver | HCC | 3.54e-06 | 2.33e+00 | 0.5341 |
158747 | MOSPD2 | S015 | Human | Liver | HCC | 4.35e-03 | 2.21e-01 | 0.2375 |
158747 | MOSPD2 | S027 | Human | Liver | HCC | 1.34e-09 | 5.68e-01 | 0.2446 |
158747 | MOSPD2 | S028 | Human | Liver | HCC | 1.53e-14 | 5.24e-01 | 0.2503 |
158747 | MOSPD2 | S029 | Human | Liver | HCC | 1.06e-14 | 5.45e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOSPD2 | SNV | Missense_Mutation | novel | c.1237N>C | p.Glu413Gln | p.E413Q | Q8NHP6 | protein_coding | tolerated(0.26) | possibly_damaging(0.715) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MOSPD2 | SNV | Missense_Mutation | c.330C>G | p.Ile110Met | p.I110M | Q8NHP6 | protein_coding | deleterious(0.03) | possibly_damaging(0.697) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
MOSPD2 | insertion | Nonsense_Mutation | novel | c.1273_1274insTATGTCATTAAATTCAGGCAATTAACAGGATAAATATTTA | p.Gln425LeufsTer4 | p.Q425Lfs*4 | Q8NHP6 | protein_coding | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MOSPD2 | deletion | Frame_Shift_Del | c.878delA | p.Lys293ArgfsTer21 | p.K293Rfs*21 | Q8NHP6 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MOSPD2 | deletion | Frame_Shift_Del | novel | c.1535delT | p.Phe512SerfsTer22 | p.F512Sfs*22 | Q8NHP6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
MOSPD2 | SNV | Missense_Mutation | c.499N>T | p.Ile167Phe | p.I167F | Q8NHP6 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MOSPD2 | SNV | Missense_Mutation | novel | c.846T>G | p.Ile282Met | p.I282M | Q8NHP6 | protein_coding | tolerated(0.19) | benign(0.062) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MOSPD2 | SNV | Missense_Mutation | c.352N>T | p.Asp118Tyr | p.D118Y | Q8NHP6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MOSPD2 | SNV | Missense_Mutation | c.23N>G | p.Asn8Ser | p.N8S | Q8NHP6 | protein_coding | tolerated(0.12) | benign(0.013) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MOSPD2 | SNV | Missense_Mutation | novel | c.665N>C | p.Val222Ala | p.V222A | Q8NHP6 | protein_coding | deleterious(0) | possibly_damaging(0.604) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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