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Gene: MOSPD1 |
Gene summary for MOSPD1 |
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Gene information | Species | Human | Gene symbol | MOSPD1 | Gene ID | 56180 |
Gene name | motile sperm domain containing 1 | |
Gene Alias | DJ473B4 | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9UJG1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56180 | MOSPD1 | LZE4T | Human | Esophagus | ESCC | 5.94e-08 | 2.35e-01 | 0.0811 |
56180 | MOSPD1 | LZE5T | Human | Esophagus | ESCC | 5.22e-03 | 2.17e-01 | 0.0514 |
56180 | MOSPD1 | LZE7T | Human | Esophagus | ESCC | 6.15e-06 | 3.67e-01 | 0.0667 |
56180 | MOSPD1 | LZE20T | Human | Esophagus | ESCC | 2.71e-03 | 5.58e-02 | 0.0662 |
56180 | MOSPD1 | LZE22T | Human | Esophagus | ESCC | 4.38e-02 | 1.88e-01 | 0.068 |
56180 | MOSPD1 | LZE24T | Human | Esophagus | ESCC | 3.11e-14 | 3.75e-01 | 0.0596 |
56180 | MOSPD1 | LZE6T | Human | Esophagus | ESCC | 5.37e-08 | 5.52e-01 | 0.0845 |
56180 | MOSPD1 | P1T-E | Human | Esophagus | ESCC | 3.16e-02 | 8.19e-02 | 0.0875 |
56180 | MOSPD1 | P2T-E | Human | Esophagus | ESCC | 5.01e-29 | 4.23e-01 | 0.1177 |
56180 | MOSPD1 | P4T-E | Human | Esophagus | ESCC | 8.06e-22 | 4.70e-01 | 0.1323 |
56180 | MOSPD1 | P5T-E | Human | Esophagus | ESCC | 1.70e-04 | 4.01e-02 | 0.1327 |
56180 | MOSPD1 | P8T-E | Human | Esophagus | ESCC | 7.42e-15 | 1.48e-01 | 0.0889 |
56180 | MOSPD1 | P9T-E | Human | Esophagus | ESCC | 1.14e-09 | 2.02e-01 | 0.1131 |
56180 | MOSPD1 | P10T-E | Human | Esophagus | ESCC | 8.00e-39 | 6.70e-01 | 0.116 |
56180 | MOSPD1 | P11T-E | Human | Esophagus | ESCC | 9.37e-10 | 2.17e-01 | 0.1426 |
56180 | MOSPD1 | P12T-E | Human | Esophagus | ESCC | 1.42e-23 | 2.94e-01 | 0.1122 |
56180 | MOSPD1 | P15T-E | Human | Esophagus | ESCC | 5.47e-15 | 2.47e-01 | 0.1149 |
56180 | MOSPD1 | P16T-E | Human | Esophagus | ESCC | 6.00e-14 | 7.74e-02 | 0.1153 |
56180 | MOSPD1 | P17T-E | Human | Esophagus | ESCC | 1.03e-05 | 2.51e-01 | 0.1278 |
56180 | MOSPD1 | P19T-E | Human | Esophagus | ESCC | 3.50e-04 | 5.85e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOSPD1 | SNV | Missense_Mutation | novel | c.382N>A | p.Glu128Lys | p.E128K | Q9UJG1 | protein_coding | tolerated(0.59) | benign(0.009) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOSPD1 | SNV | Missense_Mutation | c.619N>G | p.Thr207Ala | p.T207A | Q9UJG1 | protein_coding | tolerated(0.06) | possibly_damaging(0.706) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MOSPD1 | SNV | Missense_Mutation | novel | c.254N>A | p.Arg85Gln | p.R85Q | Q9UJG1 | protein_coding | tolerated(0.5) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOSPD1 | SNV | Missense_Mutation | novel | c.426N>A | p.Phe142Leu | p.F142L | Q9UJG1 | protein_coding | tolerated(0.66) | benign(0.07) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MOSPD1 | insertion | Frame_Shift_Ins | novel | c.429dupT | p.Glu144Ter | p.E144* | Q9UJG1 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | ||
MOSPD1 | SNV | Missense_Mutation | novel | c.460G>A | p.Val154Ile | p.V154I | Q9UJG1 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOSPD1 | SNV | Missense_Mutation | novel | c.154G>A | p.Val52Ile | p.V52I | Q9UJG1 | protein_coding | tolerated(0.06) | possibly_damaging(0.858) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOSPD1 | SNV | Missense_Mutation | c.425N>G | p.Phe142Cys | p.F142C | Q9UJG1 | protein_coding | tolerated(0.18) | possibly_damaging(0.775) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MOSPD1 | SNV | Missense_Mutation | rs746980149 | c.355C>T | p.Pro119Ser | p.P119S | Q9UJG1 | protein_coding | tolerated(0.12) | benign(0.216) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOSPD1 | SNV | Missense_Mutation | novel | c.595N>A | p.Ala199Thr | p.A199T | Q9UJG1 | protein_coding | tolerated(0.14) | probably_damaging(0.962) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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