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Gene: MORC4 |
Gene summary for MORC4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MORC4 | Gene ID | 79710 |
Gene name | MORC family CW-type zinc finger 4 | |
Gene Alias | ZCW4 | |
Cytomap | Xq22.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DTP6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79710 | MORC4 | LZE24T | Human | Esophagus | ESCC | 2.11e-06 | 3.40e-01 | 0.0596 |
79710 | MORC4 | P1T-E | Human | Esophagus | ESCC | 1.13e-06 | 3.31e-01 | 0.0875 |
79710 | MORC4 | P2T-E | Human | Esophagus | ESCC | 2.08e-20 | 5.05e-01 | 0.1177 |
79710 | MORC4 | P4T-E | Human | Esophagus | ESCC | 2.81e-18 | 4.72e-01 | 0.1323 |
79710 | MORC4 | P5T-E | Human | Esophagus | ESCC | 7.16e-19 | 3.05e-01 | 0.1327 |
79710 | MORC4 | P8T-E | Human | Esophagus | ESCC | 5.18e-12 | 2.44e-01 | 0.0889 |
79710 | MORC4 | P10T-E | Human | Esophagus | ESCC | 6.53e-07 | 1.93e-01 | 0.116 |
79710 | MORC4 | P11T-E | Human | Esophagus | ESCC | 1.64e-07 | 2.71e-01 | 0.1426 |
79710 | MORC4 | P12T-E | Human | Esophagus | ESCC | 1.40e-06 | 1.51e-01 | 0.1122 |
79710 | MORC4 | P15T-E | Human | Esophagus | ESCC | 3.96e-02 | 1.12e-01 | 0.1149 |
79710 | MORC4 | P16T-E | Human | Esophagus | ESCC | 2.27e-10 | 2.17e-01 | 0.1153 |
79710 | MORC4 | P17T-E | Human | Esophagus | ESCC | 2.86e-02 | 1.55e-01 | 0.1278 |
79710 | MORC4 | P21T-E | Human | Esophagus | ESCC | 1.21e-02 | 5.23e-02 | 0.1617 |
79710 | MORC4 | P22T-E | Human | Esophagus | ESCC | 1.91e-10 | 2.25e-01 | 0.1236 |
79710 | MORC4 | P23T-E | Human | Esophagus | ESCC | 1.98e-07 | 2.46e-01 | 0.108 |
79710 | MORC4 | P24T-E | Human | Esophagus | ESCC | 1.54e-03 | 1.05e-01 | 0.1287 |
79710 | MORC4 | P26T-E | Human | Esophagus | ESCC | 1.06e-15 | 3.04e-01 | 0.1276 |
79710 | MORC4 | P27T-E | Human | Esophagus | ESCC | 3.62e-08 | 1.37e-01 | 0.1055 |
79710 | MORC4 | P28T-E | Human | Esophagus | ESCC | 3.56e-06 | 2.41e-01 | 0.1149 |
79710 | MORC4 | P31T-E | Human | Esophagus | ESCC | 4.65e-07 | 7.08e-02 | 0.1251 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MORC4 | SNV | Missense_Mutation | rs777953821 | c.1772N>G | p.Ser591Cys | p.S591C | Q8TE76 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MORC4 | SNV | Missense_Mutation | c.386N>A | p.Ser129Tyr | p.S129Y | Q8TE76 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AO-A0JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | leuprolide | SD | |
MORC4 | SNV | Missense_Mutation | c.1014N>A | p.Asn338Lys | p.N338K | Q8TE76 | protein_coding | deleterious(0) | benign(0.272) | TCGA-BH-A204-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MORC4 | insertion | Frame_Shift_Ins | novel | c.1390_1391insCACCTCTCTGCTCTCCCAGTTCTTTATTC | p.Cys464SerfsTer26 | p.C464Sfs*26 | Q8TE76 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
MORC4 | insertion | Nonsense_Mutation | novel | c.872_873insCCATTTGTTATAGGGTTTTGATGCAAGTAGCTTGTCTTT | p.Thr291_Thr292insHisLeuLeuTerGlyPheAspAlaSerSerLeuSerPhe | p.T291_T292insHLL*GFDASSLSF | Q8TE76 | protein_coding | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
MORC4 | deletion | Frame_Shift_Del | c.1492delG | p.Glu498LysfsTer23 | p.E498Kfs*23 | Q8TE76 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
MORC4 | SNV | Missense_Mutation | novel | c.423N>T | p.Lys141Asn | p.K141N | Q8TE76 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MORC4 | SNV | Missense_Mutation | novel | c.2647N>A | p.Asp883Asn | p.D883N | Q8TE76 | protein_coding | tolerated(0.09) | possibly_damaging(0.604) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | novel | c.854N>G | p.Leu285Arg | p.L285R | Q8TE76 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
MORC4 | SNV | Missense_Mutation | novel | c.1052T>G | p.Val351Gly | p.V351G | Q8TE76 | protein_coding | tolerated(0.05) | possibly_damaging(0.47) | TCGA-EK-A2RM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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