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Gene: MOK |
Gene summary for MOK |
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Gene information | Species | Human | Gene symbol | MOK | Gene ID | 5891 |
Gene name | MOK protein kinase | |
Gene Alias | RAGE | |
Cytomap | 14q32.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UQ07 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5891 | MOK | LZE5T | Human | Esophagus | ESCC | 5.41e-03 | 4.52e-01 | 0.0514 |
5891 | MOK | LZE20T | Human | Esophagus | ESCC | 2.02e-04 | 1.37e-01 | 0.0662 |
5891 | MOK | LZE24T | Human | Esophagus | ESCC | 7.40e-04 | 1.60e-01 | 0.0596 |
5891 | MOK | P2T-E | Human | Esophagus | ESCC | 5.17e-13 | 2.47e-01 | 0.1177 |
5891 | MOK | P4T-E | Human | Esophagus | ESCC | 9.51e-27 | 6.25e-01 | 0.1323 |
5891 | MOK | P5T-E | Human | Esophagus | ESCC | 1.15e-12 | 1.08e-01 | 0.1327 |
5891 | MOK | P8T-E | Human | Esophagus | ESCC | 1.90e-12 | 1.60e-01 | 0.0889 |
5891 | MOK | P9T-E | Human | Esophagus | ESCC | 4.36e-16 | 3.29e-01 | 0.1131 |
5891 | MOK | P10T-E | Human | Esophagus | ESCC | 6.65e-09 | 1.60e-01 | 0.116 |
5891 | MOK | P12T-E | Human | Esophagus | ESCC | 7.41e-17 | 2.33e-01 | 0.1122 |
5891 | MOK | P15T-E | Human | Esophagus | ESCC | 4.71e-32 | 8.76e-01 | 0.1149 |
5891 | MOK | P16T-E | Human | Esophagus | ESCC | 2.52e-19 | 2.26e-01 | 0.1153 |
5891 | MOK | P17T-E | Human | Esophagus | ESCC | 4.61e-02 | 1.36e-01 | 0.1278 |
5891 | MOK | P20T-E | Human | Esophagus | ESCC | 3.29e-17 | 2.86e-01 | 0.1124 |
5891 | MOK | P21T-E | Human | Esophagus | ESCC | 6.84e-14 | 3.50e-01 | 0.1617 |
5891 | MOK | P22T-E | Human | Esophagus | ESCC | 3.66e-06 | 6.82e-02 | 0.1236 |
5891 | MOK | P23T-E | Human | Esophagus | ESCC | 5.14e-07 | 1.40e-01 | 0.108 |
5891 | MOK | P24T-E | Human | Esophagus | ESCC | 1.84e-06 | 5.73e-02 | 0.1287 |
5891 | MOK | P26T-E | Human | Esophagus | ESCC | 1.77e-24 | 3.73e-01 | 0.1276 |
5891 | MOK | P27T-E | Human | Esophagus | ESCC | 5.75e-12 | 2.71e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOK | SNV | Missense_Mutation | c.715N>A | p.Phe239Ile | p.F239I | Q9UQ07 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MOK | insertion | Nonsense_Mutation | novel | c.65_66insCTTAAACTTTTTTGTGGTCATTCATCACTGATATTACAGT | p.Gln22HisfsTer11 | p.Q22Hfs*11 | Q9UQ07 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
MOK | SNV | Missense_Mutation | c.811G>A | p.Asp271Asn | p.D271N | Q9UQ07 | protein_coding | tolerated(0.11) | possibly_damaging(0.679) | TCGA-UC-A7PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
MOK | SNV | Missense_Mutation | c.1226N>A | p.Arg409His | p.R409H | Q9UQ07 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MOK | SNV | Missense_Mutation | c.811N>A | p.Asp271Asn | p.D271N | Q9UQ07 | protein_coding | tolerated(0.11) | possibly_damaging(0.679) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MOK | SNV | Missense_Mutation | rs374797176 | c.664N>A | p.Ala222Thr | p.A222T | Q9UQ07 | protein_coding | tolerated(0.25) | benign(0.017) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
MOK | SNV | Missense_Mutation | novel | c.241A>C | p.Ile81Leu | p.I81L | Q9UQ07 | protein_coding | tolerated(0.06) | benign(0.159) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MOK | SNV | Missense_Mutation | rs754455482 | c.823N>A | p.Ala275Thr | p.A275T | Q9UQ07 | protein_coding | tolerated(0.84) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MOK | SNV | Missense_Mutation | c.1049N>T | p.Pro350Leu | p.P350L | Q9UQ07 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
MOK | SNV | Missense_Mutation | novel | c.694N>C | p.Ser232Pro | p.S232P | Q9UQ07 | protein_coding | deleterious(0.02) | benign(0.383) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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