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Gene: MOB4 |
Gene summary for MOB4 |
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Gene information | Species | Human | Gene symbol | MOB4 | Gene ID | 25843 |
Gene name | MOB family member 4, phocein | |
Gene Alias | 2C4D | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9Y3A3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25843 | MOB4 | LZE2T | Human | Esophagus | ESCC | 1.36e-02 | 6.61e-01 | 0.082 |
25843 | MOB4 | LZE4T | Human | Esophagus | ESCC | 6.10e-27 | 7.17e-01 | 0.0811 |
25843 | MOB4 | LZE5T | Human | Esophagus | ESCC | 1.21e-06 | 3.91e-01 | 0.0514 |
25843 | MOB4 | LZE7T | Human | Esophagus | ESCC | 1.51e-06 | 6.04e-01 | 0.0667 |
25843 | MOB4 | LZE8T | Human | Esophagus | ESCC | 5.53e-09 | 3.56e-01 | 0.067 |
25843 | MOB4 | LZE20T | Human | Esophagus | ESCC | 8.20e-14 | 4.71e-01 | 0.0662 |
25843 | MOB4 | LZE22T | Human | Esophagus | ESCC | 1.27e-08 | 7.17e-01 | 0.068 |
25843 | MOB4 | LZE24T | Human | Esophagus | ESCC | 6.48e-23 | 7.12e-01 | 0.0596 |
25843 | MOB4 | LZE21T | Human | Esophagus | ESCC | 1.68e-02 | 2.75e-01 | 0.0655 |
25843 | MOB4 | LZE6T | Human | Esophagus | ESCC | 3.63e-13 | 5.02e-01 | 0.0845 |
25843 | MOB4 | P1T-E | Human | Esophagus | ESCC | 5.95e-06 | 5.56e-01 | 0.0875 |
25843 | MOB4 | P2T-E | Human | Esophagus | ESCC | 6.86e-36 | 6.50e-01 | 0.1177 |
25843 | MOB4 | P4T-E | Human | Esophagus | ESCC | 4.78e-51 | 1.39e+00 | 0.1323 |
25843 | MOB4 | P5T-E | Human | Esophagus | ESCC | 1.11e-45 | 9.39e-01 | 0.1327 |
25843 | MOB4 | P8T-E | Human | Esophagus | ESCC | 2.79e-34 | 7.02e-01 | 0.0889 |
25843 | MOB4 | P9T-E | Human | Esophagus | ESCC | 2.68e-31 | 6.85e-01 | 0.1131 |
25843 | MOB4 | P10T-E | Human | Esophagus | ESCC | 4.07e-38 | 6.65e-01 | 0.116 |
25843 | MOB4 | P11T-E | Human | Esophagus | ESCC | 8.00e-26 | 9.76e-01 | 0.1426 |
25843 | MOB4 | P12T-E | Human | Esophagus | ESCC | 2.90e-60 | 1.23e+00 | 0.1122 |
25843 | MOB4 | P15T-E | Human | Esophagus | ESCC | 1.98e-51 | 1.20e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOB4 | SNV | Missense_Mutation | c.295N>G | p.Gln99Glu | p.Q99E | Q9Y3A3 | protein_coding | tolerated(0.51) | possibly_damaging(0.833) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MOB4 | SNV | Missense_Mutation | rs766976397 | c.166A>G | p.Lys56Glu | p.K56E | Q9Y3A3 | protein_coding | tolerated(0.9) | benign(0.001) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MOB4 | SNV | Missense_Mutation | c.77C>A | p.Pro26His | p.P26H | Q9Y3A3 | protein_coding | deleterious(0) | possibly_damaging(0.56) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MOB4 | SNV | Missense_Mutation | novel | c.481N>T | p.Arg161Cys | p.R161C | Q9Y3A3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MOB4 | SNV | Missense_Mutation | novel | c.446N>C | p.Lys149Thr | p.K149T | Q9Y3A3 | protein_coding | tolerated(0.11) | probably_damaging(0.914) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
MOB4 | SNV | Missense_Mutation | novel | c.500N>G | p.Phe167Cys | p.F167C | Q9Y3A3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
MOB4 | SNV | Missense_Mutation | novel | c.648G>T | p.Gln216His | p.Q216H | Q9Y3A3 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MOB4 | SNV | Missense_Mutation | novel | c.479G>A | p.Cys160Tyr | p.C160Y | Q9Y3A3 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-B5-A3FB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOB4 | SNV | Missense_Mutation | novel | c.328N>C | p.Cys110Arg | p.C110R | Q9Y3A3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MOB4 | SNV | Missense_Mutation | novel | c.392G>A | p.Gly131Asp | p.G131D | Q9Y3A3 | protein_coding | deleterious(0.02) | probably_damaging(0.92) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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