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Gene: MOB2 |
Gene summary for MOB2 |
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Gene information | Species | Human | Gene symbol | MOB2 | Gene ID | 81532 |
Gene name | MOB kinase activator 2 | |
Gene Alias | HCCA2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q70IA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81532 | MOB2 | LZE4T | Human | Esophagus | ESCC | 1.10e-02 | 4.17e-02 | 0.0811 |
81532 | MOB2 | LZE20T | Human | Esophagus | ESCC | 3.26e-03 | 3.08e-02 | 0.0662 |
81532 | MOB2 | LZE22T | Human | Esophagus | ESCC | 2.08e-02 | 1.22e-01 | 0.068 |
81532 | MOB2 | LZE24T | Human | Esophagus | ESCC | 8.08e-19 | 2.91e-01 | 0.0596 |
81532 | MOB2 | LZE21T | Human | Esophagus | ESCC | 6.84e-03 | 1.07e-01 | 0.0655 |
81532 | MOB2 | LZE6T | Human | Esophagus | ESCC | 2.09e-02 | 8.81e-02 | 0.0845 |
81532 | MOB2 | P1T-E | Human | Esophagus | ESCC | 2.38e-03 | 1.59e-01 | 0.0875 |
81532 | MOB2 | P2T-E | Human | Esophagus | ESCC | 7.62e-13 | 1.97e-01 | 0.1177 |
81532 | MOB2 | P4T-E | Human | Esophagus | ESCC | 3.60e-14 | 1.16e-01 | 0.1323 |
81532 | MOB2 | P5T-E | Human | Esophagus | ESCC | 2.08e-06 | -1.31e-02 | 0.1327 |
81532 | MOB2 | P8T-E | Human | Esophagus | ESCC | 1.87e-10 | 9.64e-02 | 0.0889 |
81532 | MOB2 | P9T-E | Human | Esophagus | ESCC | 4.85e-08 | 2.08e-01 | 0.1131 |
81532 | MOB2 | P10T-E | Human | Esophagus | ESCC | 1.68e-13 | 1.67e-01 | 0.116 |
81532 | MOB2 | P11T-E | Human | Esophagus | ESCC | 6.14e-12 | 3.53e-01 | 0.1426 |
81532 | MOB2 | P12T-E | Human | Esophagus | ESCC | 7.12e-06 | 9.21e-02 | 0.1122 |
81532 | MOB2 | P15T-E | Human | Esophagus | ESCC | 5.72e-13 | 1.84e-01 | 0.1149 |
81532 | MOB2 | P16T-E | Human | Esophagus | ESCC | 8.83e-14 | 8.25e-02 | 0.1153 |
81532 | MOB2 | P17T-E | Human | Esophagus | ESCC | 2.18e-04 | 1.22e-01 | 0.1278 |
81532 | MOB2 | P19T-E | Human | Esophagus | ESCC | 1.14e-04 | 3.05e-01 | 0.1662 |
81532 | MOB2 | P20T-E | Human | Esophagus | ESCC | 8.79e-18 | 2.90e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOB2 | SNV | Missense_Mutation | rs371484654 | c.590N>T | p.Thr197Met | p.T197M | Q70IA6 | protein_coding | tolerated(0.2) | benign(0.067) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MOB2 | SNV | Missense_Mutation | novel | c.238N>A | p.Glu80Lys | p.E80K | Q70IA6 | protein_coding | tolerated(0.07) | benign(0.294) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
MOB2 | SNV | Missense_Mutation | rs766850515 | c.410N>T | p.Thr137Met | p.T137M | Q70IA6 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-XS-A8TJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MOB2 | SNV | Missense_Mutation | rs369650668 | c.236N>A | p.Arg79His | p.R79H | Q70IA6 | protein_coding | tolerated(0.28) | benign(0.041) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MOB2 | SNV | Missense_Mutation | c.475N>C | p.Phe159Leu | p.F159L | Q70IA6 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MOB2 | SNV | Missense_Mutation | rs189715976 | c.202N>A | p.Asp68Asn | p.D68N | Q70IA6 | protein_coding | deleterious(0.04) | benign(0.148) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOB2 | SNV | Missense_Mutation | rs751069910 | c.730N>A | p.Gly244Arg | p.G244R | Q70IA6 | protein_coding | tolerated(0.41) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MOB2 | SNV | Missense_Mutation | c.451A>G | p.Lys151Glu | p.K151E | Q70IA6 | protein_coding | deleterious(0.04) | possibly_damaging(0.678) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MOB2 | SNV | Missense_Mutation | rs189715976 | c.202G>A | p.Asp68Asn | p.D68N | Q70IA6 | protein_coding | deleterious(0.04) | benign(0.148) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MOB2 | SNV | Missense_Mutation | rs369650668 | c.236G>A | p.Arg79His | p.R79H | Q70IA6 | protein_coding | tolerated(0.28) | benign(0.041) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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