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Gene: MMP11 |
Gene summary for MMP11 |
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Gene information | Species | Human | Gene symbol | MMP11 | Gene ID | 4320 |
Gene name | matrix metallopeptidase 11 | |
Gene Alias | SL-3 | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B3KQS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4320 | MMP11 | AEH-subject1 | Human | Endometrium | AEH | 1.24e-37 | -1.02e+00 | -0.3059 |
4320 | MMP11 | AEH-subject2 | Human | Endometrium | AEH | 1.25e-30 | -9.66e-01 | -0.2525 |
4320 | MMP11 | AEH-subject3 | Human | Endometrium | AEH | 4.91e-21 | -8.01e-01 | -0.2576 |
4320 | MMP11 | AEH-subject4 | Human | Endometrium | AEH | 7.37e-03 | -4.24e-01 | -0.2657 |
4320 | MMP11 | AEH-subject5 | Human | Endometrium | AEH | 8.52e-63 | -1.23e+00 | -0.2953 |
4320 | MMP11 | EEC-subject1 | Human | Endometrium | EEC | 9.72e-52 | -1.16e+00 | -0.2682 |
4320 | MMP11 | EEC-subject2 | Human | Endometrium | EEC | 9.32e-53 | -1.15e+00 | -0.2607 |
4320 | MMP11 | EEC-subject3 | Human | Endometrium | EEC | 5.24e-56 | -1.13e+00 | -0.2525 |
4320 | MMP11 | EEC-subject4 | Human | Endometrium | EEC | 2.88e-52 | -1.14e+00 | -0.2571 |
4320 | MMP11 | EEC-subject5 | Human | Endometrium | EEC | 1.22e-40 | -1.04e+00 | -0.249 |
4320 | MMP11 | GSM5276934 | Human | Endometrium | EEC | 7.00e-47 | -1.09e+00 | -0.0913 |
4320 | MMP11 | GSM5276935 | Human | Endometrium | EEC | 1.31e-38 | -1.03e+00 | -0.123 |
4320 | MMP11 | GSM5276937 | Human | Endometrium | EEC | 1.10e-29 | -1.00e+00 | -0.0897 |
4320 | MMP11 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.31e-49 | -1.23e+00 | -0.1869 |
4320 | MMP11 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.92e-44 | -1.21e+00 | -0.1875 |
4320 | MMP11 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.86e-54 | -1.24e+00 | -0.1883 |
4320 | MMP11 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.49e-52 | -1.12e+00 | -0.1934 |
4320 | MMP11 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.97e-49 | -1.10e+00 | -0.1917 |
4320 | MMP11 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.88e-65 | -1.23e+00 | -0.1916 |
4320 | MMP11 | LZE21D1 | Human | Esophagus | HGIN | 1.54e-02 | 3.23e-01 | 0.0632 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002241115 | Endometrium | AEH | cellular component disassembly | 80/2100 | 443/18723 | 1.07e-05 | 2.45e-04 | 80 |
GO:00455981 | Endometrium | AEH | regulation of fat cell differentiation | 26/2100 | 139/18723 | 6.04e-03 | 3.64e-02 | 26 |
GO:0030199 | Endometrium | AEH | collagen fibril organization | 14/2100 | 61/18723 | 6.65e-03 | 3.91e-02 | 14 |
GO:002241116 | Endometrium | EEC | cellular component disassembly | 82/2168 | 443/18723 | 1.06e-05 | 2.26e-04 | 82 |
GO:00454446 | Endometrium | EEC | fat cell differentiation | 39/2168 | 229/18723 | 8.69e-03 | 4.71e-02 | 39 |
GO:00301991 | Endometrium | EEC | collagen fibril organization | 14/2168 | 61/18723 | 8.76e-03 | 4.74e-02 | 14 |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00301993 | Esophagus | ESCC | collagen fibril organization | 40/8552 | 61/18723 | 1.35e-03 | 6.44e-03 | 40 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:00717115 | Esophagus | ESCC | basement membrane organization | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00455984 | Esophagus | ESCC | regulation of fat cell differentiation | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00226172 | Esophagus | ESCC | extracellular matrix disassembly | 39/8552 | 63/18723 | 6.92e-03 | 2.52e-02 | 39 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:00454441 | Liver | HCC | fat cell differentiation | 120/7958 | 229/18723 | 1.52e-03 | 8.05e-03 | 120 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MMP11 | SNV | Missense_Mutation | c.1323G>C | p.Gln441His | p.Q441H | P24347 | protein_coding | tolerated(0.08) | probably_damaging(0.954) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MMP11 | SNV | Missense_Mutation | rs767579900 | c.1186G>A | p.Glu396Lys | p.E396K | P24347 | protein_coding | tolerated(0.15) | benign(0.265) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
MMP11 | insertion | Nonsense_Mutation | novel | c.1037_1038insTTGACCCCTACCACAGA | p.Phe347Ter | p.F347* | P24347 | protein_coding | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MMP11 | SNV | Missense_Mutation | rs879000719 | c.1001N>A | p.Arg334His | p.R334H | P24347 | protein_coding | tolerated(0.09) | benign(0.284) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MMP11 | SNV | Missense_Mutation | rs750098875 | c.1123N>A | p.Ala375Thr | p.A375T | P24347 | protein_coding | tolerated(0.63) | benign(0.049) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MMP11 | SNV | Missense_Mutation | novel | c.1246N>T | p.Arg416Trp | p.R416W | P24347 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MMP11 | SNV | Missense_Mutation | c.839A>G | p.Asn280Ser | p.N280S | P24347 | protein_coding | tolerated(0.11) | benign(0.125) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MMP11 | SNV | Missense_Mutation | rs143231653 | c.478G>A | p.Ala160Thr | p.A160T | P24347 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MMP11 | SNV | Missense_Mutation | c.1348C>A | p.Leu450Met | p.L450M | P24347 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
MMP11 | SNV | Missense_Mutation | rs563846943 | c.310C>T | p.Arg104Cys | p.R104C | P24347 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4751-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4320 | MMP11 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166865 |
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