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Gene: MLTK |
Gene summary for MLTK |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MLTK | Gene ID | 51776 |
| Gene name | mitogen-activated protein kinase kinase kinase 20 | |
| Gene Alias | AZK | |
| Cytomap | 2q31.1 | |
| Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9NYL2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51776 | MLTK | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 2.91e-04 | 5.83e-01 | 0.1557 |
| 51776 | MLTK | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 3.78e-11 | 4.39e-01 | 0.1633 |
| 51776 | MLTK | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.37e-13 | 4.30e-01 | 0.1608 |
| 51776 | MLTK | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 2.90e-14 | 5.17e-01 | 0.1604 |
| 51776 | MLTK | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.92e-09 | 4.08e-01 | 0.1621 |
| 51776 | MLTK | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.50e-02 | 3.28e-01 | 0.1619 |
| 51776 | MLTK | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.56e-05 | 3.15e-01 | 0.1602 |
| 51776 | MLTK | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 1.09e-05 | 8.92e-01 | 0.1537 |
| 51776 | MLTK | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.29e-08 | 5.79e-01 | 0.1608 |
| 51776 | MLTK | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.86e-05 | 4.80e-01 | 0.1622 |
| 51776 | MLTK | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 6.06e-08 | 3.85e-01 | 0.1575 |
| 51776 | MLTK | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 5.51e-03 | 2.62e-01 | 0.1545 |
| 51776 | MLTK | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.34e-03 | 2.80e-01 | 0.1569 |
| 51776 | MLTK | P1_S1_AK | Human | Skin | AK | 2.08e-05 | -1.54e-01 | -0.3399 |
| 51776 | MLTK | P2_S3_AK | Human | Skin | AK | 9.75e-06 | -1.54e-01 | -0.3287 |
| 51776 | MLTK | P2_S4_SCCIS | Human | Skin | SCCIS | 2.08e-05 | -1.54e-01 | -0.3043 |
| 51776 | MLTK | P3_S6_AK | Human | Skin | AK | 9.75e-06 | -1.54e-01 | -0.3256 |
| 51776 | MLTK | P4_S8_cSCC | Human | Skin | cSCC | 3.63e-02 | -1.54e-01 | -0.3095 |
| 51776 | MLTK | P5_S10_cSCC | Human | Skin | cSCC | 2.08e-05 | -1.54e-01 | -0.299 |
| 51776 | MLTK | P1_cSCC | Human | Skin | cSCC | 6.54e-11 | 6.52e-01 | 0.0292 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04010 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
| hsa040101 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
| hsa040102 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
| hsa040103 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
| hsa040108 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
| hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
| hsa0401021 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
| hsa0401031 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
| hsa040104 | Lung | AAH | MAPK signaling pathway | 27/348 | 302/8465 | 1.13e-04 | 6.32e-03 | 5.08e-03 | 27 |
| hsa040105 | Lung | AAH | MAPK signaling pathway | 27/348 | 302/8465 | 1.13e-04 | 6.32e-03 | 5.08e-03 | 27 |
| hsa040106 | Lung | MIAC | MAPK signaling pathway | 32/507 | 302/8465 | 1.12e-03 | 1.36e-02 | 9.81e-03 | 32 |
| hsa040107 | Lung | MIAC | MAPK signaling pathway | 32/507 | 302/8465 | 1.12e-03 | 1.36e-02 | 9.81e-03 | 32 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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