Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MLLT4

Gene summary for MLLT4

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MLLT4

Gene ID

4301

Gene nameafadin, adherens junction formation factor
Gene AliasAF6
Cytomap6q27
Gene Typeprotein-coding
GO ID

GO:0001885

UniProtAcc

P55196


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4301MLLT4HTA11_99999970781_79442HumanColorectumMSS1.42e-581.04e+000.294
4301MLLT4HTA11_99999965062_69753HumanColorectumMSI-H2.60e-169.63e-010.3487
4301MLLT4HTA11_99999965104_69814HumanColorectumMSS1.91e-541.44e+000.281
4301MLLT4HTA11_99999971662_82457HumanColorectumMSS4.78e-488.53e-010.3859
4301MLLT4HTA11_99999973899_84307HumanColorectumMSS1.50e-166.07e-010.2585
4301MLLT4HTA11_99999974143_84620HumanColorectumMSS1.75e-184.59e-010.3005
4301MLLT4P1T-EHumanEsophagusESCC2.65e-124.95e-010.0875
4301MLLT4P2T-EHumanEsophagusESCC1.59e-305.02e-010.1177
4301MLLT4P4T-EHumanEsophagusESCC1.13e-254.70e-010.1323
4301MLLT4P5T-EHumanEsophagusESCC3.87e-346.10e-010.1327
4301MLLT4P8T-EHumanEsophagusESCC9.78e-305.54e-010.0889
4301MLLT4P9T-EHumanEsophagusESCC1.08e-072.08e-010.1131
4301MLLT4P10T-EHumanEsophagusESCC2.27e-213.59e-010.116
4301MLLT4P11T-EHumanEsophagusESCC4.74e-031.93e-010.1426
4301MLLT4P12T-EHumanEsophagusESCC5.17e-275.13e-010.1122
4301MLLT4P15T-EHumanEsophagusESCC3.20e-254.99e-010.1149
4301MLLT4P16T-EHumanEsophagusESCC4.17e-051.64e-010.1153
4301MLLT4P17T-EHumanEsophagusESCC3.47e-144.83e-010.1278
4301MLLT4P20T-EHumanEsophagusESCC1.35e-112.62e-010.1124
4301MLLT4P21T-EHumanEsophagusESCC3.02e-265.07e-010.1617
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0452020CervixCCAdherens junction33/126793/84656.99e-077.31e-064.32e-0633
hsa0453020CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa0467020CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0401512CervixCCRap1 signaling pathway56/1267210/84656.23e-065.61e-053.32e-0556
hsa040142CervixCCRas signaling pathway51/1267236/84653.55e-031.34e-027.91e-0351
hsa04520110CervixCCAdherens junction33/126793/84656.99e-077.31e-064.32e-0633
hsa04530110CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa04670110CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0401513CervixCCRap1 signaling pathway56/1267210/84656.23e-065.61e-053.32e-0556
hsa0401411CervixCCRas signaling pathway51/1267236/84653.55e-031.34e-027.91e-0351
hsa0467025CervixHSIL_HPVLeukocyte transendothelial migration16/459114/84654.04e-043.49e-032.82e-0316
hsa0467035CervixHSIL_HPVLeukocyte transendothelial migration16/459114/84654.04e-043.49e-032.82e-0316
hsa04520ColorectumADAdherens junction50/209293/84651.52e-092.83e-081.81e-0850
hsa04530ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa04015ColorectumADRap1 signaling pathway71/2092210/84651.72e-039.68e-036.18e-0371
hsa04670ColorectumADLeukocyte transendothelial migration41/2092114/84654.60e-032.20e-021.40e-0241
hsa045201ColorectumADAdherens junction50/209293/84651.52e-092.83e-081.81e-0850
hsa045301ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa040151ColorectumADRap1 signaling pathway71/2092210/84651.72e-039.68e-036.18e-0371
hsa046701ColorectumADLeukocyte transendothelial migration41/2092114/84654.60e-032.20e-021.40e-0241
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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