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Gene: MLLT11 |
Gene summary for MLLT11 |
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Gene information | Species | Human | Gene symbol | MLLT11 | Gene ID | 10962 |
Gene name | MLLT11 transcription factor 7 cofactor | |
Gene Alias | AF1Q | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001836 | UniProtAcc | Q13015 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10962 | MLLT11 | LZE4T | Human | Esophagus | ESCC | 8.37e-15 | 7.66e-01 | 0.0811 |
10962 | MLLT11 | LZE6T | Human | Esophagus | ESCC | 1.18e-06 | 3.71e-01 | 0.0845 |
10962 | MLLT11 | P2T-E | Human | Esophagus | ESCC | 9.93e-61 | 1.03e+00 | 0.1177 |
10962 | MLLT11 | P4T-E | Human | Esophagus | ESCC | 5.70e-48 | 1.26e+00 | 0.1323 |
10962 | MLLT11 | P8T-E | Human | Esophagus | ESCC | 2.92e-10 | 3.98e-01 | 0.0889 |
10962 | MLLT11 | P9T-E | Human | Esophagus | ESCC | 2.14e-09 | 3.90e-01 | 0.1131 |
10962 | MLLT11 | P10T-E | Human | Esophagus | ESCC | 1.55e-24 | 5.26e-01 | 0.116 |
10962 | MLLT11 | P11T-E | Human | Esophagus | ESCC | 1.78e-30 | 1.43e+00 | 0.1426 |
10962 | MLLT11 | P12T-E | Human | Esophagus | ESCC | 4.57e-21 | 3.72e-01 | 0.1122 |
10962 | MLLT11 | P15T-E | Human | Esophagus | ESCC | 1.98e-04 | 2.24e-01 | 0.1149 |
10962 | MLLT11 | P16T-E | Human | Esophagus | ESCC | 5.44e-20 | 4.35e-01 | 0.1153 |
10962 | MLLT11 | P19T-E | Human | Esophagus | ESCC | 1.13e-07 | 9.68e-01 | 0.1662 |
10962 | MLLT11 | P21T-E | Human | Esophagus | ESCC | 1.90e-71 | 2.13e+00 | 0.1617 |
10962 | MLLT11 | P22T-E | Human | Esophagus | ESCC | 4.08e-18 | 4.23e-01 | 0.1236 |
10962 | MLLT11 | P24T-E | Human | Esophagus | ESCC | 1.46e-04 | 2.91e-01 | 0.1287 |
10962 | MLLT11 | P26T-E | Human | Esophagus | ESCC | 1.61e-32 | 6.08e-01 | 0.1276 |
10962 | MLLT11 | P27T-E | Human | Esophagus | ESCC | 1.57e-14 | 2.96e-01 | 0.1055 |
10962 | MLLT11 | P28T-E | Human | Esophagus | ESCC | 1.34e-02 | 9.22e-02 | 0.1149 |
10962 | MLLT11 | P30T-E | Human | Esophagus | ESCC | 1.28e-08 | 4.49e-01 | 0.137 |
10962 | MLLT11 | P31T-E | Human | Esophagus | ESCC | 7.21e-05 | 2.99e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:0010821110 | Esophagus | ESCC | regulation of mitochondrion organization | 107/8552 | 144/18723 | 2.31e-12 | 9.41e-11 | 107 |
GO:0008637110 | Esophagus | ESCC | apoptotic mitochondrial changes | 83/8552 | 107/18723 | 1.43e-11 | 5.08e-10 | 83 |
GO:001082215 | Esophagus | ESCC | positive regulation of mitochondrion organization | 58/8552 | 74/18723 | 8.55e-09 | 1.73e-07 | 58 |
GO:000183619 | Esophagus | ESCC | release of cytochrome c from mitochondria | 47/8552 | 59/18723 | 9.02e-08 | 1.51e-06 | 47 |
GO:009019914 | Esophagus | ESCC | regulation of release of cytochrome c from mitochondria | 38/8552 | 48/18723 | 2.11e-06 | 2.43e-05 | 38 |
GO:005188110 | Esophagus | ESCC | regulation of mitochondrial membrane potential | 51/8552 | 74/18723 | 4.42e-05 | 3.51e-04 | 51 |
GO:00902004 | Esophagus | ESCC | positive regulation of release of cytochrome c from mitochondria | 22/8552 | 28/18723 | 3.95e-04 | 2.26e-03 | 22 |
GO:009719322 | Liver | HCC | intrinsic apoptotic signaling pathway | 184/7958 | 288/18723 | 1.50e-13 | 8.32e-12 | 184 |
GO:009719122 | Liver | HCC | extrinsic apoptotic signaling pathway | 143/7958 | 219/18723 | 6.99e-12 | 2.97e-10 | 143 |
GO:001082112 | Liver | HCC | regulation of mitochondrion organization | 96/7958 | 144/18723 | 3.82e-09 | 1.02e-07 | 96 |
GO:000863712 | Liver | HCC | apoptotic mitochondrial changes | 70/7958 | 107/18723 | 1.39e-06 | 2.01e-05 | 70 |
GO:001082211 | Liver | HCC | positive regulation of mitochondrion organization | 48/7958 | 74/18723 | 8.50e-05 | 7.46e-04 | 48 |
GO:000183612 | Liver | HCC | release of cytochrome c from mitochondria | 39/7958 | 59/18723 | 2.14e-04 | 1.63e-03 | 39 |
GO:005188112 | Liver | HCC | regulation of mitochondrial membrane potential | 45/7958 | 74/18723 | 1.13e-03 | 6.43e-03 | 45 |
GO:00901995 | Liver | HCC | regulation of release of cytochrome c from mitochondria | 31/7958 | 48/18723 | 1.66e-03 | 8.71e-03 | 31 |
GO:009719320 | Oral cavity | OSCC | intrinsic apoptotic signaling pathway | 202/7305 | 288/18723 | 4.64e-27 | 1.73e-24 | 202 |
GO:009719120 | Oral cavity | OSCC | extrinsic apoptotic signaling pathway | 142/7305 | 219/18723 | 7.34e-15 | 4.55e-13 | 142 |
GO:000863718 | Oral cavity | OSCC | apoptotic mitochondrial changes | 78/7305 | 107/18723 | 1.06e-12 | 4.78e-11 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MLLT11 | SNV | Missense_Mutation | novel | c.187N>T | p.Gly63Cys | p.G63C | Q13015 | protein_coding | deleterious(0.02) | possibly_damaging(0.891) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MLLT11 | SNV | Missense_Mutation | c.232N>T | p.Pro78Ser | p.P78S | Q13015 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MLLT11 | SNV | Missense_Mutation | novel | c.190N>C | p.Asp64His | p.D64H | Q13015 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MLLT11 | SNV | Missense_Mutation | novel | c.124G>T | p.Asp42Tyr | p.D42Y | Q13015 | protein_coding | deleterious(0.01) | benign(0.444) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MLLT11 | SNV | Missense_Mutation | c.256G>A | p.Glu86Lys | p.E86K | Q13015 | protein_coding | deleterious(0.01) | benign(0.242) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MLLT11 | SNV | Missense_Mutation | novel | c.174G>T | p.Glu58Asp | p.E58D | Q13015 | protein_coding | tolerated(0.46) | benign(0.254) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MLLT11 | SNV | Missense_Mutation | c.88C>A | p.Leu30Met | p.L30M | Q13015 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MLLT11 | SNV | Missense_Mutation | novel | c.91G>T | p.Gly31Cys | p.G31C | Q13015 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MLLT11 | SNV | Missense_Mutation | c.256N>A | p.Glu86Lys | p.E86K | Q13015 | protein_coding | deleterious(0.01) | benign(0.242) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MLLT11 | SNV | Missense_Mutation | c.256N>A | p.Glu86Lys | p.E86K | Q13015 | protein_coding | deleterious(0.01) | benign(0.242) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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