Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MLEC

Gene summary for MLEC

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MLEC

Gene ID

9761

Gene namemalectin
Gene AliasKIAA0152
Cytomap12q24.31
Gene Typeprotein-coding
GO ID

GO:0005975

UniProtAcc

F5GX14


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9761MLECCA_HPV_1HumanCervixCC1.42e-08-2.05e-010.0264
9761MLECCA_HPV_3HumanCervixCC2.02e-05-1.83e-010.0414
9761MLECN_HPV_2HumanCervixN_HPV2.00e-03-1.82e-01-0.0131
9761MLECCCI_1HumanCervixCC3.48e-04-5.58e-010.528
9761MLECCCI_3HumanCervixCC1.93e-03-4.84e-010.516
9761MLECCCII_1HumanCervixCC7.21e-11-5.88e-010.3249
9761MLECTumorHumanCervixCC1.48e-08-3.97e-010.1241
9761MLECsample3HumanCervixCC1.35e-13-3.53e-010.1387
9761MLECL1HumanCervixCC2.10e-08-4.63e-010.0802
9761MLECT1HumanCervixCC1.97e-03-3.49e-010.0918
9761MLECT3HumanCervixCC2.20e-12-2.97e-010.1389
9761MLECHTA11_1938_2000001011HumanColorectumAD4.27e-118.32e-01-0.0811
9761MLECHTA11_78_2000001011HumanColorectumAD9.69e-046.15e-01-0.1088
9761MLECHTA11_347_2000001011HumanColorectumAD1.09e-231.12e+00-0.1954
9761MLECHTA11_411_2000001011HumanColorectumSER1.78e-026.84e-01-0.2602
9761MLECHTA11_83_2000001011HumanColorectumSER4.74e-128.95e-01-0.1526
9761MLECHTA11_696_2000001011HumanColorectumAD2.62e-076.68e-01-0.1464
9761MLECHTA11_866_2000001011HumanColorectumAD3.22e-066.01e-01-0.1001
9761MLECHTA11_1391_2000001011HumanColorectumAD1.63e-141.18e+00-0.059
9761MLECHTA11_546_2000001011HumanColorectumAD6.58e-129.16e-01-0.0842
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MLECSNVMissense_Mutationc.415N>Tp.Val139Leup.V139LQ14165protein_codingdeleterious(0)probably_damaging(0.963)TCGA-AN-A0XV-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
MLECSNVMissense_Mutationc.595N>Cp.Tyr199Hisp.Y199HQ14165protein_codingtolerated(0.31)benign(0.242)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
MLECSNVMissense_Mutationc.316N>Ap.Glu106Lysp.E106KQ14165protein_codingtolerated(0.65)benign(0.094)TCGA-EK-A2RA-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
MLECSNVMissense_Mutationrs768581342c.757N>Tp.Arg253Trpp.R253WQ14165protein_codingdeleterious(0)probably_damaging(0.979)TCGA-AA-3977-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MLECSNVMissense_Mutationc.259C>Tp.Pro87Serp.P87SQ14165protein_codingtolerated(0.45)benign(0.017)TCGA-AD-6964-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyfolfoxPD
MLECSNVMissense_Mutationnovelc.530N>Cp.Lys177Thrp.K177TQ14165protein_codingdeleterious(0.05)benign(0.267)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
MLECSNVMissense_Mutationc.268C>Ap.Arg90Serp.R90SQ14165protein_codingdeleterious(0)probably_damaging(0.998)TCGA-G4-6626-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MLECSNVMissense_Mutationrs373698097c.334G>Ap.Glu112Lysp.E112KQ14165protein_codingdeleterious(0.01)possibly_damaging(0.54)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MLECSNVMissense_Mutationnovelc.248G>Tp.Gly83Valp.G83VQ14165protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MLECSNVMissense_Mutationc.308N>Ap.Arg103Glnp.R103QQ14165protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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