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Gene: MLEC |
Gene summary for MLEC |
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Gene information | Species | Human | Gene symbol | MLEC | Gene ID | 9761 |
Gene name | malectin | |
Gene Alias | KIAA0152 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | F5GX14 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9761 | MLEC | CA_HPV_1 | Human | Cervix | CC | 1.42e-08 | -2.05e-01 | 0.0264 |
9761 | MLEC | CA_HPV_3 | Human | Cervix | CC | 2.02e-05 | -1.83e-01 | 0.0414 |
9761 | MLEC | N_HPV_2 | Human | Cervix | N_HPV | 2.00e-03 | -1.82e-01 | -0.0131 |
9761 | MLEC | CCI_1 | Human | Cervix | CC | 3.48e-04 | -5.58e-01 | 0.528 |
9761 | MLEC | CCI_3 | Human | Cervix | CC | 1.93e-03 | -4.84e-01 | 0.516 |
9761 | MLEC | CCII_1 | Human | Cervix | CC | 7.21e-11 | -5.88e-01 | 0.3249 |
9761 | MLEC | Tumor | Human | Cervix | CC | 1.48e-08 | -3.97e-01 | 0.1241 |
9761 | MLEC | sample3 | Human | Cervix | CC | 1.35e-13 | -3.53e-01 | 0.1387 |
9761 | MLEC | L1 | Human | Cervix | CC | 2.10e-08 | -4.63e-01 | 0.0802 |
9761 | MLEC | T1 | Human | Cervix | CC | 1.97e-03 | -3.49e-01 | 0.0918 |
9761 | MLEC | T3 | Human | Cervix | CC | 2.20e-12 | -2.97e-01 | 0.1389 |
9761 | MLEC | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.27e-11 | 8.32e-01 | -0.0811 |
9761 | MLEC | HTA11_78_2000001011 | Human | Colorectum | AD | 9.69e-04 | 6.15e-01 | -0.1088 |
9761 | MLEC | HTA11_347_2000001011 | Human | Colorectum | AD | 1.09e-23 | 1.12e+00 | -0.1954 |
9761 | MLEC | HTA11_411_2000001011 | Human | Colorectum | SER | 1.78e-02 | 6.84e-01 | -0.2602 |
9761 | MLEC | HTA11_83_2000001011 | Human | Colorectum | SER | 4.74e-12 | 8.95e-01 | -0.1526 |
9761 | MLEC | HTA11_696_2000001011 | Human | Colorectum | AD | 2.62e-07 | 6.68e-01 | -0.1464 |
9761 | MLEC | HTA11_866_2000001011 | Human | Colorectum | AD | 3.22e-06 | 6.01e-01 | -0.1001 |
9761 | MLEC | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.63e-14 | 1.18e+00 | -0.059 |
9761 | MLEC | HTA11_546_2000001011 | Human | Colorectum | AD | 6.58e-12 | 9.16e-01 | -0.0842 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MLEC | SNV | Missense_Mutation | c.415N>T | p.Val139Leu | p.V139L | Q14165 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AN-A0XV-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MLEC | SNV | Missense_Mutation | c.595N>C | p.Tyr199His | p.Y199H | Q14165 | protein_coding | tolerated(0.31) | benign(0.242) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
MLEC | SNV | Missense_Mutation | c.316N>A | p.Glu106Lys | p.E106K | Q14165 | protein_coding | tolerated(0.65) | benign(0.094) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
MLEC | SNV | Missense_Mutation | rs768581342 | c.757N>T | p.Arg253Trp | p.R253W | Q14165 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MLEC | SNV | Missense_Mutation | c.259C>T | p.Pro87Ser | p.P87S | Q14165 | protein_coding | tolerated(0.45) | benign(0.017) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
MLEC | SNV | Missense_Mutation | novel | c.530N>C | p.Lys177Thr | p.K177T | Q14165 | protein_coding | deleterious(0.05) | benign(0.267) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MLEC | SNV | Missense_Mutation | c.268C>A | p.Arg90Ser | p.R90S | Q14165 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G4-6626-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MLEC | SNV | Missense_Mutation | rs373698097 | c.334G>A | p.Glu112Lys | p.E112K | Q14165 | protein_coding | deleterious(0.01) | possibly_damaging(0.54) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MLEC | SNV | Missense_Mutation | novel | c.248G>T | p.Gly83Val | p.G83V | Q14165 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MLEC | SNV | Missense_Mutation | c.308N>A | p.Arg103Gln | p.R103Q | Q14165 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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