Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MKRN1

Gene summary for MKRN1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MKRN1

Gene ID

23608

Gene namemakorin ring finger protein 1
Gene AliasRNF61
Cytomap7q34
Gene Typeprotein-coding
GO ID

GO:0000209

UniProtAcc

Q9UHC7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23608MKRN1HTA11_78_2000001011HumanColorectumAD6.53e-034.19e-01-0.1088
23608MKRN1HTA11_347_2000001011HumanColorectumAD5.65e-146.40e-01-0.1954
23608MKRN1HTA11_99999970781_79442HumanColorectumMSS6.07e-044.07e-010.294
23608MKRN1A015-C-203HumanColorectumFAP1.12e-098.21e-02-0.1294
23608MKRN1A001-C-119HumanColorectumFAP4.00e-033.92e-01-0.1557
23608MKRN1A001-C-108HumanColorectumFAP2.36e-02-9.57e-03-0.0272
23608MKRN1A002-C-205HumanColorectumFAP1.61e-054.30e-02-0.1236
23608MKRN1A015-C-006HumanColorectumFAP7.39e-04-9.69e-02-0.0994
23608MKRN1A002-C-114HumanColorectumFAP1.21e-03-4.43e-02-0.1561
23608MKRN1A015-C-104HumanColorectumFAP7.10e-094.73e-02-0.1899
23608MKRN1A002-C-016HumanColorectumFAP9.65e-051.88e-020.0521
23608MKRN1A002-C-116HumanColorectumFAP2.28e-121.28e-01-0.0452
23608MKRN1A014-C-008HumanColorectumFAP7.15e-037.53e-02-0.191
23608MKRN1A018-E-020HumanColorectumFAP3.77e-061.76e-01-0.2034
23608MKRN1F034HumanColorectumFAP4.51e-047.90e-02-0.0665
23608MKRN1LZE2DHumanEsophagusHGIN2.11e-021.72e-010.0642
23608MKRN1LZE4THumanEsophagusESCC3.88e-021.83e-010.0811
23608MKRN1LZE7THumanEsophagusESCC2.85e-095.43e-010.0667
23608MKRN1LZE8THumanEsophagusESCC2.76e-03-6.00e-030.067
23608MKRN1LZE20THumanEsophagusESCC1.69e-105.13e-010.0662
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0000209ColorectumADprotein polyubiquitination78/3918236/187238.71e-062.06e-0478
GO:00002092ColorectumMSSprotein polyubiquitination72/3467236/187235.19e-061.42e-0472
GO:00002093ColorectumFAPprotein polyubiquitination59/2622236/187234.53e-061.52e-0459
GO:000020916EsophagusHGINprotein polyubiquitination58/2587236/187236.29e-061.97e-0458
GO:000020917EsophagusESCCprotein polyubiquitination170/8552236/187231.40e-161.09e-14170
GO:000020911LiverCirrhoticprotein polyubiquitination89/4634236/187236.09e-069.80e-0589
GO:000020921LiverHCCprotein polyubiquitination151/7958236/187231.90e-117.59e-10151
GO:000020910Oral cavityOSCCprotein polyubiquitination150/7305236/187231.59e-149.27e-13150
GO:000020915Oral cavityLPprotein polyubiquitination82/4623236/187233.23e-043.26e-0382
GO:00002099ProstateBPHprotein polyubiquitination64/3107236/187232.83e-053.31e-0464
GO:000020914ProstateTumorprotein polyubiquitination64/3246236/187231.08e-041.03e-0364
GO:000020924SkincSCCprotein polyubiquitination103/4864236/187232.57e-099.09e-08103
GO:000020920ThyroidPTCprotein polyubiquitination128/5968236/187237.81e-133.65e-11128
GO:0000209110ThyroidATCprotein polyubiquitination134/6293236/187231.86e-139.20e-12134
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MKRN1SNVMissense_Mutationc.1294N>Ap.Phe432Ilep.F432IQ9UHC7protein_codingdeleterious(0.02)possibly_damaging(0.758)TCGA-AO-A124-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
MKRN1SNVMissense_Mutationc.1336N>Ap.Glu446Lysp.E446KQ9UHC7protein_codingtolerated(0.19)benign(0.05)TCGA-C8-A12P-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MKRN1insertionNonsense_Mutationnovelc.572_573insTTGTATTGAATGACAGGAAGAGATCCp.Gln192CysfsTer4p.Q192Cfs*4Q9UHC7protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MKRN1SNVMissense_Mutationrs765877418c.542G>Ap.Arg181Hisp.R181HQ9UHC7protein_codingdeleterious(0)benign(0.152)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
MKRN1SNVMissense_Mutationc.1336N>Ap.Glu446Lysp.E446KQ9UHC7protein_codingtolerated(0.19)benign(0.05)TCGA-AA-3811-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
MKRN1SNVMissense_Mutationnovelc.73N>Ap.Ala25Thrp.A25TQ9UHC7protein_codingtolerated(0.28)benign(0.014)TCGA-AD-6895-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
MKRN1SNVMissense_Mutationc.286N>Ap.Gly96Argp.G96RQ9UHC7protein_codingtolerated(0.07)benign(0.137)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
MKRN1SNVMissense_Mutationnovelc.1375G>Ap.Glu459Lysp.E459KQ9UHC7protein_codingtolerated(0.13)benign(0.011)TCGA-F5-6814-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
MKRN1SNVMissense_Mutationrs528516903c.254C>Tp.Pro85Leup.P85LQ9UHC7protein_codingtolerated(0.1)benign(0.011)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MKRN1SNVMissense_Mutationrs376798349c.824G>Ap.Arg275Hisp.R275HQ9UHC7protein_codingtolerated(0.08)benign(0.066)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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