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Gene: MKL2 |
Gene summary for MKL2 |
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Gene information | Species | Human | Gene symbol | MKL2 | Gene ID | 57496 |
Gene name | myocardin related transcription factor B | |
Gene Alias | MKL2 | |
Cytomap | 16p13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9ULH7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57496 | MKL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.93e-43 | -9.29e-01 | 0.0155 |
57496 | MKL2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.81e-27 | -9.29e-01 | -0.1808 |
57496 | MKL2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.25e-07 | -9.29e-01 | 0.0216 |
57496 | MKL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.65e-21 | -9.29e-01 | -0.0811 |
57496 | MKL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.30e-31 | -9.29e-01 | -0.1088 |
57496 | MKL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.18e-46 | -9.29e-01 | -0.1954 |
57496 | MKL2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.33e-04 | -9.29e-01 | -0.2602 |
57496 | MKL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.80e-06 | -9.29e-01 | -0.2196 |
57496 | MKL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.06e-21 | -9.29e-01 | -0.1207 |
57496 | MKL2 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.89e-18 | -9.29e-01 | -0.1526 |
57496 | MKL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.20e-62 | -9.29e-01 | -0.1464 |
57496 | MKL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.48e-58 | -9.29e-01 | -0.1001 |
57496 | MKL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.30e-36 | -9.29e-01 | -0.059 |
57496 | MKL2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.85e-09 | -9.29e-01 | -0.1706 |
57496 | MKL2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.26e-10 | -9.29e-01 | -0.2061 |
57496 | MKL2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.25e-07 | -9.29e-01 | -0.1462 |
57496 | MKL2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.30e-15 | -9.29e-01 | -0.0842 |
57496 | MKL2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.33e-04 | -9.29e-01 | -0.00410000000000005 |
57496 | MKL2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.02e-13 | -9.29e-01 | -0.0179 |
57496 | MKL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.83e-39 | -9.29e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MKL2 | SNV | Missense_Mutation | c.1450N>C | p.Glu484Gln | p.E484Q | Q9ULH7 | protein_coding | tolerated(0.44) | benign(0.011) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MKL2 | SNV | Missense_Mutation | c.1364N>C | p.Val455Ala | p.V455A | Q9ULH7 | protein_coding | tolerated(0.26) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MKL2 | SNV | Missense_Mutation | c.72N>C | p.Gln24His | p.Q24H | Q9ULH7 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD | |
MKL2 | SNV | Missense_Mutation | novel | c.2546N>A | p.Gly849Glu | p.G849E | Q9ULH7 | protein_coding | deleterious(0) | benign(0.038) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MKL2 | SNV | Missense_Mutation | c.1077C>G | p.Phe359Leu | p.F359L | Q9ULH7 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MKL2 | SNV | Missense_Mutation | c.946N>A | p.Glu316Lys | p.E316K | Q9ULH7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
MKL2 | SNV | Missense_Mutation | novel | c.2362N>C | p.Phe788Leu | p.F788L | Q9ULH7 | protein_coding | tolerated(0.62) | benign(0.087) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
MKL2 | SNV | Missense_Mutation | rs767875492 | c.2863N>T | p.Arg955Trp | p.R955W | Q9ULH7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
MKL2 | deletion | Frame_Shift_Del | novel | c.2130delT | p.Val711LeufsTer8 | p.V711Lfs*8 | Q9ULH7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
MKL2 | SNV | Missense_Mutation | c.439N>G | p.Gln147Glu | p.Q147E | Q9ULH7 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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