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Gene: MIRLET7BHG |
Gene summary for MIRLET7BHG |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MIRLET7BHG | Gene ID | 400931 |
| Gene name | MIRLET7B host gene | |
| Gene Alias | linc-Ppara | |
| Cytomap | 22q13.31 | |
| Gene Type | ncRNA | GO ID | GO:0008150 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 400931 | MIRLET7BHG | CCI_1 | Human | Cervix | CC | 3.64e-23 | 9.69e-01 | 0.528 |
| 400931 | MIRLET7BHG | CCI_2 | Human | Cervix | CC | 1.21e-16 | 1.21e+00 | 0.5249 |
| 400931 | MIRLET7BHG | CCI_3 | Human | Cervix | CC | 8.97e-58 | 2.02e+00 | 0.516 |
| 400931 | MIRLET7BHG | CCII_1 | Human | Cervix | CC | 1.97e-08 | 2.32e-01 | 0.3249 |
| 400931 | MIRLET7BHG | Tumor | Human | Cervix | CC | 7.65e-03 | 8.53e-02 | 0.1241 |
| 400931 | MIRLET7BHG | sample3 | Human | Cervix | CC | 1.88e-05 | 1.07e-01 | 0.1387 |
| 400931 | MIRLET7BHG | H2 | Human | Cervix | HSIL_HPV | 3.40e-02 | 7.22e-02 | 0.0632 |
| 400931 | MIRLET7BHG | T3 | Human | Cervix | CC | 1.88e-05 | 1.08e-01 | 0.1389 |
| 400931 | MIRLET7BHG | LZE7T | Human | Esophagus | ESCC | 3.72e-06 | 2.66e-01 | 0.0667 |
| 400931 | MIRLET7BHG | LZE22T | Human | Esophagus | ESCC | 5.26e-04 | 4.14e-01 | 0.068 |
| 400931 | MIRLET7BHG | P1T-E | Human | Esophagus | ESCC | 8.90e-07 | 3.80e-01 | 0.0875 |
| 400931 | MIRLET7BHG | P2T-E | Human | Esophagus | ESCC | 5.66e-06 | 1.77e-01 | 0.1177 |
| 400931 | MIRLET7BHG | P4T-E | Human | Esophagus | ESCC | 1.40e-05 | 1.32e-01 | 0.1323 |
| 400931 | MIRLET7BHG | P5T-E | Human | Esophagus | ESCC | 2.42e-03 | 8.49e-02 | 0.1327 |
| 400931 | MIRLET7BHG | P8T-E | Human | Esophagus | ESCC | 8.53e-07 | 1.10e-01 | 0.0889 |
| 400931 | MIRLET7BHG | P9T-E | Human | Esophagus | ESCC | 2.46e-04 | 1.04e-01 | 0.1131 |
| 400931 | MIRLET7BHG | P10T-E | Human | Esophagus | ESCC | 1.81e-17 | 3.46e-01 | 0.116 |
| 400931 | MIRLET7BHG | P11T-E | Human | Esophagus | ESCC | 1.33e-05 | 4.26e-01 | 0.1426 |
| 400931 | MIRLET7BHG | P15T-E | Human | Esophagus | ESCC | 3.20e-02 | 6.53e-02 | 0.1149 |
| 400931 | MIRLET7BHG | P16T-E | Human | Esophagus | ESCC | 6.59e-14 | 2.01e-01 | 0.1153 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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