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Gene: MINOS1 |
Gene summary for MINOS1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MINOS1 | Gene ID | 440574 |
| Gene name | mitochondrial contact site and cristae organizing system subunit 10 | |
| Gene Alias | C1orf151 | |
| Cytomap | 1p36.13 | |
| Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5TGZ0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 440574 | MINOS1 | GSM4909281 | Human | Breast | IDC | 1.53e-05 | 3.59e-01 | 0.21 |
| 440574 | MINOS1 | GSM4909282 | Human | Breast | IDC | 1.78e-16 | 5.17e-01 | -0.0288 |
| 440574 | MINOS1 | GSM4909285 | Human | Breast | IDC | 1.29e-02 | -1.51e-01 | 0.21 |
| 440574 | MINOS1 | GSM4909289 | Human | Breast | IDC | 1.09e-04 | 4.82e-01 | 0.1064 |
| 440574 | MINOS1 | GSM4909293 | Human | Breast | IDC | 3.65e-07 | 3.65e-01 | 0.1581 |
| 440574 | MINOS1 | GSM4909294 | Human | Breast | IDC | 2.01e-11 | 1.37e-01 | 0.2022 |
| 440574 | MINOS1 | GSM4909296 | Human | Breast | IDC | 5.18e-19 | 2.78e-01 | 0.1524 |
| 440574 | MINOS1 | GSM4909297 | Human | Breast | IDC | 8.76e-20 | 1.38e-01 | 0.1517 |
| 440574 | MINOS1 | GSM4909298 | Human | Breast | IDC | 7.27e-17 | 4.61e-01 | 0.1551 |
| 440574 | MINOS1 | GSM4909301 | Human | Breast | IDC | 2.20e-42 | 7.16e-01 | 0.1577 |
| 440574 | MINOS1 | GSM4909302 | Human | Breast | IDC | 4.87e-08 | 2.71e-01 | 0.1545 |
| 440574 | MINOS1 | GSM4909304 | Human | Breast | IDC | 2.92e-16 | 4.60e-01 | 0.1636 |
| 440574 | MINOS1 | GSM4909306 | Human | Breast | IDC | 3.87e-24 | 5.78e-01 | 0.1564 |
| 440574 | MINOS1 | GSM4909311 | Human | Breast | IDC | 2.19e-42 | -2.51e-01 | 0.1534 |
| 440574 | MINOS1 | GSM4909312 | Human | Breast | IDC | 1.71e-14 | -1.22e-01 | 0.1552 |
| 440574 | MINOS1 | GSM4909313 | Human | Breast | IDC | 1.99e-05 | 2.11e-01 | 0.0391 |
| 440574 | MINOS1 | GSM4909315 | Human | Breast | IDC | 1.72e-02 | 2.32e-01 | 0.21 |
| 440574 | MINOS1 | GSM4909316 | Human | Breast | IDC | 2.01e-15 | 5.10e-01 | 0.21 |
| 440574 | MINOS1 | GSM4909319 | Human | Breast | IDC | 7.46e-49 | -2.73e-01 | 0.1563 |
| 440574 | MINOS1 | GSM4909320 | Human | Breast | IDC | 3.15e-06 | -1.40e-01 | 0.1575 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MINOS1 | SNV | Missense_Mutation | rs377291144 | c.31N>A | p.Asp11Asn | p.D11N | Q5TGZ0 | protein_coding | deleterious(0.02) | possibly_damaging(0.864) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| MINOS1 | SNV | Missense_Mutation | novel | c.116G>T | p.Arg39Ile | p.R39I | Q5TGZ0 | protein_coding | deleterious(0) | possibly_damaging(0.678) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MINOS1 | SNV | Missense_Mutation | novel | c.101N>G | p.Thr34Ser | p.T34S | Q5TGZ0 | protein_coding | deleterious(0.01) | benign(0.097) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| MINOS1 | insertion | Frame_Shift_Ins | novel | c.149dupG | p.Leu51IlefsTer11 | p.L51Ifs*11 | Q5TGZ0 | protein_coding | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| MINOS1 | SNV | Missense_Mutation | novel | c.202C>G | p.Leu68Val | p.L68V | Q5TGZ0 | protein_coding | tolerated(0.13) | benign(0.029) | TCGA-CV-5444-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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