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Gene: MICU1 |
Gene summary for MICU1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MICU1 | Gene ID | 10367 |
| Gene name | mitochondrial calcium uptake 1 | |
| Gene Alias | CALC | |
| Cytomap | 10q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9BPX6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10367 | MICU1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.70e-08 | -2.47e-01 | 0.0155 |
| 10367 | MICU1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.84e-02 | 5.79e-01 | -0.2602 |
| 10367 | MICU1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.74e-02 | -2.93e-01 | -0.2061 |
| 10367 | MICU1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.28e-11 | -4.82e-01 | 0.3005 |
| 10367 | MICU1 | A001-C-207 | Human | Colorectum | FAP | 2.32e-02 | -1.87e-01 | 0.1278 |
| 10367 | MICU1 | A015-C-203 | Human | Colorectum | FAP | 2.32e-21 | -3.39e-01 | -0.1294 |
| 10367 | MICU1 | A015-C-204 | Human | Colorectum | FAP | 1.72e-06 | -3.08e-01 | -0.0228 |
| 10367 | MICU1 | A014-C-040 | Human | Colorectum | FAP | 3.96e-05 | -2.56e-01 | -0.1184 |
| 10367 | MICU1 | A002-C-201 | Human | Colorectum | FAP | 1.60e-11 | -3.20e-01 | 0.0324 |
| 10367 | MICU1 | A002-C-203 | Human | Colorectum | FAP | 5.09e-03 | -1.56e-01 | 0.2786 |
| 10367 | MICU1 | A001-C-119 | Human | Colorectum | FAP | 1.29e-04 | -1.41e-01 | -0.1557 |
| 10367 | MICU1 | A001-C-108 | Human | Colorectum | FAP | 9.89e-14 | -2.22e-01 | -0.0272 |
| 10367 | MICU1 | A002-C-205 | Human | Colorectum | FAP | 1.63e-19 | -2.74e-01 | -0.1236 |
| 10367 | MICU1 | A015-C-005 | Human | Colorectum | FAP | 1.31e-02 | -1.37e-01 | -0.0336 |
| 10367 | MICU1 | A015-C-006 | Human | Colorectum | FAP | 1.36e-14 | -3.40e-01 | -0.0994 |
| 10367 | MICU1 | A015-C-106 | Human | Colorectum | FAP | 6.73e-09 | -2.19e-01 | -0.0511 |
| 10367 | MICU1 | A002-C-114 | Human | Colorectum | FAP | 9.92e-18 | -3.48e-01 | -0.1561 |
| 10367 | MICU1 | A015-C-104 | Human | Colorectum | FAP | 1.68e-24 | -2.16e-01 | -0.1899 |
| 10367 | MICU1 | A001-C-014 | Human | Colorectum | FAP | 2.39e-14 | -2.74e-01 | 0.0135 |
| 10367 | MICU1 | A002-C-016 | Human | Colorectum | FAP | 1.57e-20 | -3.53e-01 | 0.0521 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
| GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
| GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
| GO:0051560 | Colorectum | AD | mitochondrial calcium ion homeostasis | 13/3918 | 26/18723 | 9.41e-04 | 8.92e-03 | 13 |
| GO:0036444 | Colorectum | AD | calcium import into the mitochondrion | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
| GO:0006851 | Colorectum | AD | mitochondrial calcium ion transmembrane transport | 10/3918 | 20/18723 | 3.67e-03 | 2.60e-02 | 10 |
| GO:0071472 | Colorectum | AD | cellular response to salt stress | 7/3918 | 12/18723 | 5.09e-03 | 3.38e-02 | 7 |
| GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
| GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
| GO:00621971 | Colorectum | SER | cellular response to chemical stress | 87/2897 | 337/18723 | 5.33e-07 | 2.59e-05 | 87 |
| GO:00068511 | Colorectum | SER | mitochondrial calcium ion transmembrane transport | 10/2897 | 20/18723 | 3.20e-04 | 5.15e-03 | 10 |
| GO:00364441 | Colorectum | SER | calcium import into the mitochondrion | 8/2897 | 14/18723 | 4.06e-04 | 6.07e-03 | 8 |
| GO:00515601 | Colorectum | SER | mitochondrial calcium ion homeostasis | 11/2897 | 26/18723 | 9.60e-04 | 1.15e-02 | 11 |
| GO:0051561 | Colorectum | SER | positive regulation of mitochondrial calcium ion concentration | 6/2897 | 11/18723 | 3.12e-03 | 2.70e-02 | 6 |
| GO:0006970 | Colorectum | SER | response to osmotic stress | 23/2897 | 84/18723 | 3.61e-03 | 3.03e-02 | 23 |
| GO:00714721 | Colorectum | SER | cellular response to salt stress | 6/2897 | 12/18723 | 5.42e-03 | 4.03e-02 | 6 |
| GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
| GO:00621972 | Colorectum | MSS | cellular response to chemical stress | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
| GO:19905422 | Colorectum | MSS | mitochondrial transmembrane transport | 41/3467 | 102/18723 | 2.70e-07 | 1.11e-05 | 41 |
| GO:00515602 | Colorectum | MSS | mitochondrial calcium ion homeostasis | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
| Page: 1 2 3 4 5 6 7 8 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MICU1 | SNV | Missense_Mutation | novel | c.395N>A | p.Ala132Asp | p.A132D | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
| MICU1 | SNV | Missense_Mutation | novel | c.218N>C | p.Lys73Thr | p.K73T | Q9BPX6 | protein_coding | tolerated_low_confidence(0.12) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MICU1 | SNV | Missense_Mutation | rs754124319 | c.523C>T | p.Arg175Cys | p.R175C | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
| MICU1 | SNV | Missense_Mutation | c.232G>C | p.Asp78His | p.D78H | Q9BPX6 | protein_coding | deleterious(0.03) | benign(0) | TCGA-EW-A6SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tch | SD | |
| MICU1 | SNV | Missense_Mutation | novel | c.23N>T | p.Ser8Phe | p.S8F | Q9BPX6 | protein_coding | deleterious_low_confidence(0.03) | benign(0.365) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| MICU1 | deletion | Frame_Shift_Del | novel | c.721delN | p.Glu241LysfsTer47 | p.E241Kfs*47 | Q9BPX6 | protein_coding | TCGA-BH-A1EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| MICU1 | SNV | Missense_Mutation | rs367648335 | c.775C>T | p.Arg259Cys | p.R259C | Q9BPX6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| MICU1 | SNV | Missense_Mutation | rs752729268 | c.524N>A | p.Arg175His | p.R175H | Q9BPX6 | protein_coding | deleterious(0.04) | benign(0.072) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| MICU1 | SNV | Missense_Mutation | c.451N>T | p.Asp151Tyr | p.D151Y | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
| MICU1 | SNV | Missense_Mutation | rs750157034 | c.776N>A | p.Arg259His | p.R259H | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 10367 | MICU1 | TRANSPORTER | ALD-403 | EPTINEZUMAB | ||
| 10367 | MICU1 | TRANSPORTER | PF-4427429 |
| Page: 1 |
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