Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MICOS13

Gene summary for MICOS13

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MICOS13

Gene ID

125988

Gene namemitochondrial contact site and cristae organizing system subunit 13
Gene AliasC19orf70
Cytomap19p13.3
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

A0A140TA86


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
125988MICOS13CA_HPV_1HumanCervixCC5.01e-08-2.15e-010.0264
125988MICOS13CCI_1HumanCervixCC2.73e-04-5.59e-010.528
125988MICOS13CCI_3HumanCervixCC4.08e-04-4.78e-010.516
125988MICOS13CCII_1HumanCervixCC3.65e-15-6.00e-010.3249
125988MICOS13TumorHumanCervixCC5.86e-41-6.00e-010.1241
125988MICOS13HTA11_3410_2000001011HumanColorectumAD1.23e-041.28e-010.0155
125988MICOS13HTA11_2487_2000001011HumanColorectumSER2.43e-184.33e-01-0.1808
125988MICOS13HTA11_1938_2000001011HumanColorectumAD3.85e-144.51e-01-0.0811
125988MICOS13HTA11_78_2000001011HumanColorectumAD5.53e-031.14e-01-0.1088
125988MICOS13HTA11_347_2000001011HumanColorectumAD1.01e-203.96e-01-0.1954
125988MICOS13HTA11_411_2000001011HumanColorectumSER2.78e-053.68e-01-0.2602
125988MICOS13HTA11_2112_2000001011HumanColorectumSER3.88e-116.10e-01-0.2196
125988MICOS13HTA11_3361_2000001011HumanColorectumAD1.71e-103.09e-01-0.1207
125988MICOS13HTA11_83_2000001011HumanColorectumSER4.95e-164.42e-01-0.1526
125988MICOS13HTA11_696_2000001011HumanColorectumAD6.56e-264.41e-01-0.1464
125988MICOS13HTA11_866_2000001011HumanColorectumAD7.82e-133.08e-01-0.1001
125988MICOS13HTA11_1391_2000001011HumanColorectumAD2.92e-143.71e-01-0.059
125988MICOS13HTA11_2992_2000001011HumanColorectumSER1.72e-052.87e-01-0.1706
125988MICOS13HTA11_5212_2000001011HumanColorectumAD5.12e-052.80e-01-0.2061
125988MICOS13HTA11_5216_2000001011HumanColorectumSER1.84e-104.15e-01-0.1462
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00070067CervixCCmitochondrial membrane organization28/2311116/187233.28e-043.47e-0328
GO:00070074CervixCCinner mitochondrial membrane organization11/231138/187234.94e-032.95e-0211
GO:0007006ColorectumADmitochondrial membrane organization48/3918116/187234.53e-071.72e-0548
GO:0007007ColorectumADinner mitochondrial membrane organization18/391838/187232.45e-043.09e-0318
GO:00070061ColorectumSERmitochondrial membrane organization38/2897116/187232.66e-061.10e-0438
GO:00070071ColorectumSERinner mitochondrial membrane organization14/289738/187231.06e-031.23e-0214
GO:000700618EsophagusHGINmitochondrial membrane organization37/2587116/187234.61e-072.07e-0537
GO:00070076EsophagusHGINinner mitochondrial membrane organization16/258738/187231.82e-054.93e-0416
GO:000700619EsophagusESCCmitochondrial membrane organization93/8552116/187232.16e-141.11e-1293
GO:000700713EsophagusESCCinner mitochondrial membrane organization31/855238/187235.93e-066.10e-0531
GO:00424072EsophagusESCCcristae formation13/855216/187234.05e-031.62e-0213
GO:00070069ProstateBPHmitochondrial membrane organization35/3107116/187231.98e-041.63e-0335
GO:000700616ProstateTumormitochondrial membrane organization35/3246116/187234.65e-043.48e-0335
GO:000700620SkinAKmitochondrial membrane organization25/1910116/187232.31e-042.56e-0325
GO:0007006110SkincSCCmitochondrial membrane organization64/4864116/187232.16e-111.08e-0964
GO:00070077SkincSCCinner mitochondrial membrane organization24/486438/187231.54e-062.62e-0524
GO:00424073SkincSCCcristae formation9/486416/187239.73e-034.31e-029
GO:00070064StomachGCmitochondrial membrane organization18/1159116/187232.71e-044.44e-0318
GO:000700611StomachCAG with IMmitochondrial membrane organization18/1050116/187237.92e-051.86e-0318
GO:000700621StomachCSGmitochondrial membrane organization18/1034116/187236.51e-051.61e-0318
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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