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Gene: MGAM2 |
Gene summary for MGAM2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MGAM2 | Gene ID | 93432 |
Gene name | maltase-glucoamylase 2 (putative) | |
Gene Alias | MGAM2 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q2M2H8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93432 | MGAM2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.60e-08 | 3.39e-01 | -0.059 |
93432 | MGAM2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.19e-05 | 1.14e+00 | 0.3487 |
93432 | MGAM2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.30e-26 | 9.21e-01 | 0.281 |
93432 | MGAM2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.12e-25 | 5.48e-01 | 0.3859 |
93432 | MGAM2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.10e-16 | 4.26e-01 | 0.3005 |
93432 | MGAM2 | A001-C-007 | Human | Colorectum | CRC | 1.37e-12 | 6.30e-01 | 0.1899 |
93432 | MGAM2 | F072B | Human | Colorectum | FAP | 2.11e-24 | 6.74e-01 | 0.257 |
93432 | MGAM2 | CRC-1-8810 | Human | Colorectum | CRC | 9.17e-50 | 1.04e+00 | 0.6257 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGAM2 | SNV | Missense_Mutation | novel | c.4101N>C | p.Leu1367Phe | p.L1367F | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.4474A>G | p.Ile1492Val | p.I1492V | Q2M2H8 | protein_coding | tolerated(0.09) | benign(0.196) | TCGA-A2-A0T6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.4520N>T | p.Gly1507Val | p.G1507V | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.3956N>T | p.Asp1319Val | p.D1319V | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-AC-A2BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.4406N>T | p.Ser1469Phe | p.S1469F | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
MGAM2 | SNV | Missense_Mutation | rs570637188 | c.6459N>A | p.Ser2153Arg | p.S2153R | Q2M2H8 | protein_coding | deleterious_low_confidence(0.01) | unknown(0) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
MGAM2 | SNV | Missense_Mutation | novel | c.1505C>A | p.Pro502His | p.P502H | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MGAM2 | SNV | Missense_Mutation | novel | c.4522G>A | p.Ala1508Thr | p.A1508T | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MGAM2 | SNV | Missense_Mutation | novel | c.4838C>G | p.Ala1613Gly | p.A1613G | Q2M2H8 | protein_coding | tolerated(0.07) | benign(0.227) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MGAM2 | SNV | Missense_Mutation | novel | c.3550C>A | p.Gln1184Lys | p.Q1184K | Q2M2H8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C5-A7UI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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