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Gene: MFSD2B |
Gene summary for MFSD2B |
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Gene information | Species | Human | Gene symbol | MFSD2B | Gene ID | 388931 |
Gene name | major facilitator superfamily domain containing 2B | |
Gene Alias | SLC59A2 | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A6NFX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388931 | MFSD2B | C21 | Human | Oral cavity | OSCC | 1.36e-07 | 1.34e-01 | 0.2678 |
388931 | MFSD2B | C30 | Human | Oral cavity | OSCC | 2.78e-20 | 7.21e-01 | 0.3055 |
388931 | MFSD2B | C38 | Human | Oral cavity | OSCC | 4.94e-06 | 6.61e-01 | 0.172 |
388931 | MFSD2B | C46 | Human | Oral cavity | OSCC | 2.66e-11 | 2.57e-01 | 0.1673 |
388931 | MFSD2B | C08 | Human | Oral cavity | OSCC | 1.93e-05 | 1.35e-01 | 0.1919 |
388931 | MFSD2B | LN38 | Human | Oral cavity | OSCC | 8.77e-05 | 4.81e-01 | 0.168 |
388931 | MFSD2B | LN46 | Human | Oral cavity | OSCC | 4.70e-04 | 2.05e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD2B | SNV | Missense_Mutation | rs759338733 | c.1138N>A | p.Val380Met | p.V380M | A6NFX1 | protein_coding | tolerated(0.16) | benign(0.165) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MFSD2B | SNV | Missense_Mutation | c.953T>C | p.Val318Ala | p.V318A | A6NFX1 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
MFSD2B | SNV | Missense_Mutation | rs531128708 | c.1279N>A | p.Ala427Thr | p.A427T | A6NFX1 | protein_coding | deleterious(0) | possibly_damaging(0.599) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MFSD2B | SNV | Missense_Mutation | rs751215494 | c.1387G>A | p.Ala463Thr | p.A463T | A6NFX1 | protein_coding | deleterious(0.01) | possibly_damaging(0.701) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MFSD2B | SNV | Missense_Mutation | c.373G>A | p.Ala125Thr | p.A125T | A6NFX1 | protein_coding | tolerated(0.13) | benign(0.036) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MFSD2B | SNV | Missense_Mutation | rs762530433 | c.637N>A | p.Glu213Lys | p.E213K | A6NFX1 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-AA-3982-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
MFSD2B | SNV | Missense_Mutation | rs773602625 | c.1024N>T | p.Arg342Cys | p.R342C | A6NFX1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
MFSD2B | SNV | Missense_Mutation | c.275C>T | p.Ala92Val | p.A92V | A6NFX1 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MFSD2B | SNV | Missense_Mutation | c.674N>T | p.Pro225Leu | p.P225L | A6NFX1 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MFSD2B | SNV | Missense_Mutation | rs751782427 | c.698N>C | p.Ile233Thr | p.I233T | A6NFX1 | protein_coding | tolerated(0.06) | benign(0.062) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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