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Gene: MFSD11 |
Gene summary for MFSD11 |
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Gene information | Species | Human | Gene symbol | MFSD11 | Gene ID | 79157 |
Gene name | major facilitator superfamily domain containing 11 | |
Gene Alias | ET | |
Cytomap | 17q25.1-q25.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R8U7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79157 | MFSD11 | LZE2T | Human | Esophagus | ESCC | 1.30e-03 | 3.93e-01 | 0.082 |
79157 | MFSD11 | LZE4T | Human | Esophagus | ESCC | 2.16e-09 | 2.53e-01 | 0.0811 |
79157 | MFSD11 | LZE5T | Human | Esophagus | ESCC | 1.30e-03 | 3.16e-01 | 0.0514 |
79157 | MFSD11 | LZE7T | Human | Esophagus | ESCC | 4.63e-11 | 3.73e-01 | 0.0667 |
79157 | MFSD11 | LZE8T | Human | Esophagus | ESCC | 3.16e-02 | 9.40e-02 | 0.067 |
79157 | MFSD11 | LZE20T | Human | Esophagus | ESCC | 3.63e-02 | 1.67e-01 | 0.0662 |
79157 | MFSD11 | LZE21D1 | Human | Esophagus | HGIN | 1.31e-03 | 4.41e-01 | 0.0632 |
79157 | MFSD11 | LZE22T | Human | Esophagus | ESCC | 9.98e-07 | 5.35e-01 | 0.068 |
79157 | MFSD11 | LZE24T | Human | Esophagus | ESCC | 1.33e-26 | 5.76e-01 | 0.0596 |
79157 | MFSD11 | LZE21T | Human | Esophagus | ESCC | 2.20e-08 | 3.96e-01 | 0.0655 |
79157 | MFSD11 | LZE6T | Human | Esophagus | ESCC | 1.02e-08 | 2.52e-01 | 0.0845 |
79157 | MFSD11 | P1T-E | Human | Esophagus | ESCC | 7.45e-15 | 6.51e-01 | 0.0875 |
79157 | MFSD11 | P2T-E | Human | Esophagus | ESCC | 9.41e-39 | 5.77e-01 | 0.1177 |
79157 | MFSD11 | P4T-E | Human | Esophagus | ESCC | 1.78e-14 | 3.13e-01 | 0.1323 |
79157 | MFSD11 | P5T-E | Human | Esophagus | ESCC | 3.11e-11 | 2.18e-01 | 0.1327 |
79157 | MFSD11 | P8T-E | Human | Esophagus | ESCC | 7.89e-21 | 4.37e-01 | 0.0889 |
79157 | MFSD11 | P9T-E | Human | Esophagus | ESCC | 3.69e-16 | 2.94e-01 | 0.1131 |
79157 | MFSD11 | P10T-E | Human | Esophagus | ESCC | 1.93e-20 | 3.27e-01 | 0.116 |
79157 | MFSD11 | P11T-E | Human | Esophagus | ESCC | 7.20e-26 | 9.52e-01 | 0.1426 |
79157 | MFSD11 | P12T-E | Human | Esophagus | ESCC | 1.48e-29 | 5.31e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD11 | SNV | Missense_Mutation | c.149N>G | p.Thr50Ser | p.T50S | O43934 | protein_coding | tolerated(0.1) | possibly_damaging(0.811) | TCGA-A2-A0T4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | femara | SD | |
MFSD11 | SNV | Missense_Mutation | c.952N>T | p.His318Tyr | p.H318Y | O43934 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MFSD11 | SNV | Missense_Mutation | c.14N>G | p.Ser5Cys | p.S5C | O43934 | protein_coding | deleterious(0.05) | possibly_damaging(0.635) | TCGA-D8-A1XB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MFSD11 | insertion | Frame_Shift_Ins | novel | c.1003_1004insCTTCAGTATCATTAAATACATTCACAATGTTAAGCAATCATCATCTC | p.Ile335ThrfsTer101 | p.I335Tfs*101 | O43934 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
MFSD11 | SNV | Missense_Mutation | rs549274131 | c.911N>A | p.Arg304His | p.R304H | O43934 | protein_coding | deleterious(0.03) | benign(0.068) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MFSD11 | SNV | Missense_Mutation | c.1324C>T | p.Arg442Cys | p.R442C | O43934 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-C5-A8XI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
MFSD11 | SNV | Missense_Mutation | novel | c.245N>A | p.Ser82Asn | p.S82N | O43934 | protein_coding | deleterious(0.01) | possibly_damaging(0.579) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MFSD11 | SNV | Missense_Mutation | c.124N>G | p.Thr42Ala | p.T42A | O43934 | protein_coding | tolerated(0.39) | possibly_damaging(0.688) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MFSD11 | SNV | Missense_Mutation | rs765041697 | c.640N>A | p.Glu214Lys | p.E214K | O43934 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MFSD11 | SNV | Missense_Mutation | c.532N>A | p.Val178Met | p.V178M | O43934 | protein_coding | deleterious(0.05) | probably_damaging(0.957) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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