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Gene: MFSD1 |
Gene summary for MFSD1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MFSD1 | Gene ID | 64747 |
| Gene name | major facilitator superfamily domain containing 1 | |
| Gene Alias | Minerva | |
| Cytomap | 3q25.32 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H3U5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64747 | MFSD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.87e-02 | 2.99e-01 | -0.0811 |
| 64747 | MFSD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.58e-23 | 6.85e-01 | -0.1954 |
| 64747 | MFSD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.01e-02 | 3.35e-01 | -0.1526 |
| 64747 | MFSD1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.91e-04 | 4.40e-01 | -0.0177 |
| 64747 | MFSD1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.16e-02 | 6.78e-01 | -0.0124 |
| 64747 | MFSD1 | LZE2T | Human | Esophagus | ESCC | 2.04e-02 | 2.63e-01 | 0.082 |
| 64747 | MFSD1 | LZE4T | Human | Esophagus | ESCC | 7.23e-13 | 5.59e-01 | 0.0811 |
| 64747 | MFSD1 | LZE7T | Human | Esophagus | ESCC | 5.58e-03 | 2.40e-01 | 0.0667 |
| 64747 | MFSD1 | LZE8T | Human | Esophagus | ESCC | 1.56e-07 | 3.34e-01 | 0.067 |
| 64747 | MFSD1 | LZE24T | Human | Esophagus | ESCC | 1.33e-23 | 8.84e-01 | 0.0596 |
| 64747 | MFSD1 | P1T-E | Human | Esophagus | ESCC | 4.10e-05 | 7.38e-01 | 0.0875 |
| 64747 | MFSD1 | P2T-E | Human | Esophagus | ESCC | 1.26e-57 | 1.08e+00 | 0.1177 |
| 64747 | MFSD1 | P4T-E | Human | Esophagus | ESCC | 6.27e-28 | 7.22e-01 | 0.1323 |
| 64747 | MFSD1 | P5T-E | Human | Esophagus | ESCC | 2.52e-12 | 2.39e-01 | 0.1327 |
| 64747 | MFSD1 | P8T-E | Human | Esophagus | ESCC | 2.51e-39 | 9.15e-01 | 0.0889 |
| 64747 | MFSD1 | P9T-E | Human | Esophagus | ESCC | 2.25e-11 | 3.46e-01 | 0.1131 |
| 64747 | MFSD1 | P10T-E | Human | Esophagus | ESCC | 4.09e-32 | 5.85e-01 | 0.116 |
| 64747 | MFSD1 | P11T-E | Human | Esophagus | ESCC | 8.81e-09 | 6.78e-01 | 0.1426 |
| 64747 | MFSD1 | P12T-E | Human | Esophagus | ESCC | 5.70e-27 | 5.03e-01 | 0.1122 |
| 64747 | MFSD1 | P15T-E | Human | Esophagus | ESCC | 4.15e-18 | 6.11e-01 | 0.1149 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
| GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
| GO:0072665 | Colorectum | AD | protein localization to vacuole | 27/3918 | 67/18723 | 2.40e-04 | 3.04e-03 | 27 |
| GO:0061462 | Colorectum | AD | protein localization to lysosome | 19/3918 | 46/18723 | 1.36e-03 | 1.19e-02 | 19 |
| GO:00316471 | Colorectum | SER | regulation of protein stability | 86/2897 | 298/18723 | 2.56e-09 | 2.42e-07 | 86 |
| GO:00508211 | Colorectum | SER | protein stabilization | 58/2897 | 191/18723 | 1.46e-07 | 8.59e-06 | 58 |
| GO:00726651 | Colorectum | SER | protein localization to vacuole | 19/2897 | 67/18723 | 5.14e-03 | 3.93e-02 | 19 |
| GO:00160509 | Esophagus | HGIN | vesicle organization | 65/2587 | 300/18723 | 1.24e-04 | 2.54e-03 | 65 |
| GO:00069975 | Esophagus | HGIN | nucleus organization | 34/2587 | 133/18723 | 2.20e-04 | 4.00e-03 | 34 |
| GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
| GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
| GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
| GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
| GO:00726659 | Esophagus | ESCC | protein localization to vacuole | 52/8552 | 67/18723 | 9.14e-08 | 1.52e-06 | 52 |
| GO:00614626 | Esophagus | ESCC | protein localization to lysosome | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
| GO:00461482 | Esophagus | ESCC | pigment biosynthetic process | 40/8552 | 62/18723 | 2.14e-03 | 9.54e-03 | 40 |
| GO:00434731 | Esophagus | ESCC | pigmentation | 59/8552 | 98/18723 | 2.64e-03 | 1.12e-02 | 59 |
| GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
| GO:00424401 | Esophagus | ESCC | pigment metabolic process | 50/8552 | 84/18723 | 7.34e-03 | 2.64e-02 | 50 |
| GO:003164712 | Liver | Cirrhotic | regulation of protein stability | 144/4634 | 298/18723 | 6.74e-19 | 1.28e-16 | 144 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MFSD1 | SNV | Missense_Mutation | rs745622550 | c.1474N>T | p.Arg492Cys | p.R492C | Q9H3U5 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-E9-A1N8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| MFSD1 | SNV | Missense_Mutation | rs757890714 | c.1220C>T | p.Ala407Val | p.A407V | Q9H3U5 | protein_coding | tolerated(0.06) | possibly_damaging(0.876) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MFSD1 | SNV | Missense_Mutation | novel | c.1228N>G | p.Leu410Val | p.L410V | Q9H3U5 | protein_coding | tolerated(0.38) | benign(0.03) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MFSD1 | SNV | Missense_Mutation | c.1211N>A | p.Pro404His | p.P404H | Q9H3U5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| MFSD1 | SNV | Missense_Mutation | c.1270N>A | p.Pro424Thr | p.P424T | Q9H3U5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| MFSD1 | SNV | Missense_Mutation | novel | c.1438N>C | p.Ser480Pro | p.S480P | Q9H3U5 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MFSD1 | SNV | Missense_Mutation | novel | c.869N>T | p.Arg290Ile | p.R290I | Q9H3U5 | protein_coding | deleterious(0.02) | possibly_damaging(0.8) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| MFSD1 | SNV | Missense_Mutation | c.1342N>T | p.Leu448Phe | p.L448F | Q9H3U5 | protein_coding | deleterious(0.03) | probably_damaging(0.929) | TCGA-F4-6855-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MFSD1 | SNV | Missense_Mutation | c.967N>A | p.Val323Ile | p.V323I | Q9H3U5 | protein_coding | tolerated(0.08) | possibly_damaging(0.612) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MFSD1 | SNV | Missense_Mutation | novel | c.761N>A | p.Ser254Tyr | p.S254Y | Q9H3U5 | protein_coding | tolerated(1) | benign(0.012) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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