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Gene: MEX3C |
Gene summary for MEX3C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MEX3C | Gene ID | 51320 |
| Gene name | mex-3 RNA binding family member C | |
| Gene Alias | BM-013 | |
| Cytomap | 18q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q5U5Q3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51320 | MEX3C | C04 | Human | Oral cavity | OSCC | 1.83e-02 | 2.51e-01 | 0.2633 |
| 51320 | MEX3C | C21 | Human | Oral cavity | OSCC | 1.89e-04 | 2.05e-01 | 0.2678 |
| 51320 | MEX3C | C30 | Human | Oral cavity | OSCC | 3.33e-21 | 7.47e-01 | 0.3055 |
| 51320 | MEX3C | C38 | Human | Oral cavity | OSCC | 3.97e-07 | 8.37e-01 | 0.172 |
| 51320 | MEX3C | C43 | Human | Oral cavity | OSCC | 8.67e-07 | 2.20e-01 | 0.1704 |
| 51320 | MEX3C | C51 | Human | Oral cavity | OSCC | 1.26e-02 | 1.45e-01 | 0.2674 |
| 51320 | MEX3C | C57 | Human | Oral cavity | OSCC | 1.79e-04 | 2.67e-01 | 0.1679 |
| 51320 | MEX3C | C08 | Human | Oral cavity | OSCC | 4.43e-09 | 2.68e-01 | 0.1919 |
| 51320 | MEX3C | LN46 | Human | Oral cavity | OSCC | 4.73e-02 | 9.05e-02 | 0.1666 |
| 51320 | MEX3C | SYSMH1 | Human | Oral cavity | OSCC | 1.20e-02 | 1.08e-01 | 0.1127 |
| 51320 | MEX3C | SYSMH3 | Human | Oral cavity | OSCC | 1.05e-06 | 1.90e-01 | 0.2442 |
| 51320 | MEX3C | SYSMH6 | Human | Oral cavity | OSCC | 3.23e-02 | 6.78e-02 | 0.1275 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
| GO:00454448 | Oral cavity | OSCC | fat cell differentiation | 120/7305 | 229/18723 | 2.48e-05 | 2.32e-04 | 120 |
| GO:00455983 | Oral cavity | OSCC | regulation of fat cell differentiation | 77/7305 | 139/18723 | 6.36e-05 | 5.18e-04 | 77 |
| GO:00485889 | Oral cavity | OSCC | developmental cell growth | 116/7305 | 234/18723 | 6.20e-04 | 3.50e-03 | 116 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MEX3C | SNV | Missense_Mutation | c.798C>G | p.Ile266Met | p.I266M | Q5U5Q3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| MEX3C | SNV | Missense_Mutation | rs149420230 | c.1481N>C | p.Val494Ala | p.V494A | Q5U5Q3 | protein_coding | tolerated_low_confidence(0.23) | benign(0.028) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MEX3C | SNV | Missense_Mutation | c.1210N>C | p.Glu404Gln | p.E404Q | Q5U5Q3 | protein_coding | deleterious(0.02) | possibly_damaging(0.813) | TCGA-BH-A18S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MEX3C | SNV | Missense_Mutation | c.443N>T | p.Ala148Val | p.A148V | Q5U5Q3 | protein_coding | deleterious_low_confidence(0.03) | benign(0.013) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| MEX3C | insertion | Frame_Shift_Ins | novel | c.381_382insT | p.Glu128Ter | p.E128* | Q5U5Q3 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| MEX3C | insertion | Frame_Shift_Ins | novel | c.380_381insTTGTTATAGAATTCTAAACAGT | p.Glu127AspfsTer135 | p.E127Dfs*135 | Q5U5Q3 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| MEX3C | insertion | Nonsense_Mutation | novel | c.1676_1677insCTA | p.Arg559delinsSerTer | p.R559delinsS* | Q5U5Q3 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
| MEX3C | insertion | Nonsense_Mutation | novel | c.1675_1676insATCCCTTTGCAAAGTAGACTTAGCAAGAATGGAG | p.Arg559AsnfsTer6 | p.R559Nfs*6 | Q5U5Q3 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
| MEX3C | insertion | Frame_Shift_Ins | novel | c.1090_1091insAAAA | p.Ser364LysfsTer5 | p.S364Kfs*5 | Q5U5Q3 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| MEX3C | insertion | Frame_Shift_Ins | novel | c.1088_1089insATTA | p.Ser364LeufsTer5 | p.S364Lfs*5 | Q5U5Q3 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 51320 | MEX3C | ENZYME | Bisphosphonates |
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