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Gene: METTL2B |
Gene summary for METTL2B |
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Gene information | Species | Human | Gene symbol | METTL2B | Gene ID | 55798 |
Gene name | methyltransferase 2B, methylcytidine | |
Gene Alias | METL | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q6P1Q9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55798 | METTL2B | LZE4T | Human | Esophagus | ESCC | 1.33e-05 | 2.32e-01 | 0.0811 |
55798 | METTL2B | LZE7T | Human | Esophagus | ESCC | 3.08e-04 | 2.36e-01 | 0.0667 |
55798 | METTL2B | LZE20T | Human | Esophagus | ESCC | 2.05e-03 | 2.03e-01 | 0.0662 |
55798 | METTL2B | LZE24T | Human | Esophagus | ESCC | 7.32e-15 | 3.97e-01 | 0.0596 |
55798 | METTL2B | LZE6T | Human | Esophagus | ESCC | 1.96e-03 | 1.40e-01 | 0.0845 |
55798 | METTL2B | P1T-E | Human | Esophagus | ESCC | 7.08e-11 | 3.67e-01 | 0.0875 |
55798 | METTL2B | P2T-E | Human | Esophagus | ESCC | 4.27e-10 | 2.36e-01 | 0.1177 |
55798 | METTL2B | P4T-E | Human | Esophagus | ESCC | 5.25e-23 | 4.55e-01 | 0.1323 |
55798 | METTL2B | P5T-E | Human | Esophagus | ESCC | 6.71e-13 | 2.11e-01 | 0.1327 |
55798 | METTL2B | P8T-E | Human | Esophagus | ESCC | 1.02e-15 | 2.23e-01 | 0.0889 |
55798 | METTL2B | P9T-E | Human | Esophagus | ESCC | 3.21e-13 | 3.71e-01 | 0.1131 |
55798 | METTL2B | P10T-E | Human | Esophagus | ESCC | 1.09e-20 | 3.38e-01 | 0.116 |
55798 | METTL2B | P11T-E | Human | Esophagus | ESCC | 4.84e-05 | 1.89e-01 | 0.1426 |
55798 | METTL2B | P12T-E | Human | Esophagus | ESCC | 3.11e-22 | 5.24e-01 | 0.1122 |
55798 | METTL2B | P15T-E | Human | Esophagus | ESCC | 6.67e-30 | 6.26e-01 | 0.1149 |
55798 | METTL2B | P16T-E | Human | Esophagus | ESCC | 8.93e-15 | 3.13e-01 | 0.1153 |
55798 | METTL2B | P19T-E | Human | Esophagus | ESCC | 1.41e-06 | 4.15e-01 | 0.1662 |
55798 | METTL2B | P20T-E | Human | Esophagus | ESCC | 5.93e-16 | 3.10e-01 | 0.1124 |
55798 | METTL2B | P21T-E | Human | Esophagus | ESCC | 4.23e-19 | 3.80e-01 | 0.1617 |
55798 | METTL2B | P22T-E | Human | Esophagus | ESCC | 1.67e-09 | 1.22e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL2B | SNV | Missense_Mutation | c.689C>G | p.Pro230Arg | p.P230R | Q6P1Q9 | protein_coding | tolerated(0.06) | benign(0.408) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
METTL2B | SNV | Missense_Mutation | c.445N>C | p.Glu149Gln | p.E149Q | Q6P1Q9 | protein_coding | tolerated(0.5) | benign(0.007) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
METTL2B | SNV | Missense_Mutation | c.371G>C | p.Cys124Ser | p.C124S | Q6P1Q9 | protein_coding | tolerated(0.81) | benign(0) | TCGA-JX-A3PZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
METTL2B | insertion | Frame_Shift_Ins | novel | c.852_853insG | p.Met287AspfsTer11 | p.M287Dfs*11 | Q6P1Q9 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
METTL2B | SNV | Missense_Mutation | rs767735930 | c.164N>G | p.Gln55Arg | p.Q55R | Q6P1Q9 | protein_coding | tolerated(0.36) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
METTL2B | SNV | Missense_Mutation | rs144033501 | c.995C>T | p.Thr332Met | p.T332M | Q6P1Q9 | protein_coding | tolerated(0.1) | possibly_damaging(0.832) | TCGA-AA-3675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
METTL2B | SNV | Missense_Mutation | rs771135202 | c.1084N>T | p.Arg362Trp | p.R362W | Q6P1Q9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
METTL2B | SNV | Missense_Mutation | rs759278722 | c.496N>G | p.Ser166Gly | p.S166G | Q6P1Q9 | protein_coding | tolerated(0.36) | benign(0.01) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
METTL2B | SNV | Missense_Mutation | c.300C>A | p.Phe100Leu | p.F100L | Q6P1Q9 | protein_coding | deleterious(0.02) | possibly_damaging(0.728) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
METTL2B | SNV | Missense_Mutation | c.688N>A | p.Pro230Thr | p.P230T | Q6P1Q9 | protein_coding | tolerated(0.18) | benign(0.031) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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