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Gene: METTL12 |
Gene summary for METTL12 |
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Gene information | Species | Human | Gene symbol | METTL12 | Gene ID | 751071 |
Gene name | citrate synthase lysine methyltransferase | |
Gene Alias | CS-KMT | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A8MUP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
751071 | METTL12 | P1T-E | Human | Esophagus | ESCC | 4.63e-13 | 1.06e+00 | 0.0875 |
751071 | METTL12 | P2T-E | Human | Esophagus | ESCC | 1.02e-13 | 1.23e-01 | 0.1177 |
751071 | METTL12 | P4T-E | Human | Esophagus | ESCC | 4.90e-18 | 4.88e-01 | 0.1323 |
751071 | METTL12 | P5T-E | Human | Esophagus | ESCC | 3.20e-16 | 3.16e-01 | 0.1327 |
751071 | METTL12 | P8T-E | Human | Esophagus | ESCC | 1.27e-11 | 2.58e-01 | 0.0889 |
751071 | METTL12 | P9T-E | Human | Esophagus | ESCC | 1.01e-11 | 6.10e-02 | 0.1131 |
751071 | METTL12 | P10T-E | Human | Esophagus | ESCC | 2.85e-17 | 3.51e-01 | 0.116 |
751071 | METTL12 | P11T-E | Human | Esophagus | ESCC | 7.06e-06 | 8.14e-02 | 0.1426 |
751071 | METTL12 | P12T-E | Human | Esophagus | ESCC | 1.24e-17 | 2.97e-01 | 0.1122 |
751071 | METTL12 | P15T-E | Human | Esophagus | ESCC | 9.51e-05 | 3.96e-02 | 0.1149 |
751071 | METTL12 | P16T-E | Human | Esophagus | ESCC | 4.73e-14 | 1.72e-01 | 0.1153 |
751071 | METTL12 | P20T-E | Human | Esophagus | ESCC | 2.08e-21 | 5.30e-01 | 0.1124 |
751071 | METTL12 | P21T-E | Human | Esophagus | ESCC | 9.15e-18 | 1.36e-01 | 0.1617 |
751071 | METTL12 | P23T-E | Human | Esophagus | ESCC | 1.09e-11 | 2.66e-01 | 0.108 |
751071 | METTL12 | P24T-E | Human | Esophagus | ESCC | 5.81e-04 | 7.93e-02 | 0.1287 |
751071 | METTL12 | P26T-E | Human | Esophagus | ESCC | 8.61e-10 | 1.32e-01 | 0.1276 |
751071 | METTL12 | P27T-E | Human | Esophagus | ESCC | 7.20e-10 | 3.33e-01 | 0.1055 |
751071 | METTL12 | P28T-E | Human | Esophagus | ESCC | 3.13e-19 | 3.70e-01 | 0.1149 |
751071 | METTL12 | P30T-E | Human | Esophagus | ESCC | 3.99e-05 | 1.90e-01 | 0.137 |
751071 | METTL12 | P31T-E | Human | Esophagus | ESCC | 6.81e-15 | 9.33e-02 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL12 | SNV | Missense_Mutation | rs763451990 | c.167G>A | p.Gly56Glu | p.G56E | A8MUP2 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-EW-A1OX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
METTL12 | deletion | Frame_Shift_Del | novel | c.463delN | p.Gly155AlafsTer31 | p.G155Afs*31 | A8MUP2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
METTL12 | SNV | Missense_Mutation | novel | c.226N>T | p.Pro76Ser | p.P76S | A8MUP2 | protein_coding | tolerated(0.06) | benign(0.081) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | novel | c.638N>T | p.Ser213Phe | p.S213F | A8MUP2 | protein_coding | tolerated(0.09) | benign(0) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | novel | c.385N>A | p.Leu129Ile | p.L129I | A8MUP2 | protein_coding | tolerated(0.16) | benign(0.1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | novel | c.503N>A | p.Ala168Asp | p.A168D | A8MUP2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | novel | c.154N>A | p.Asp52Asn | p.D52N | A8MUP2 | protein_coding | tolerated(0.08) | probably_damaging(0.949) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | novel | c.527N>A | p.Arg176Lys | p.R176K | A8MUP2 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | rs773778431 | c.641A>G | p.Tyr214Cys | p.Y214C | A8MUP2 | protein_coding | tolerated(0.18) | benign(0) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
METTL12 | SNV | Missense_Mutation | novel | c.365N>A | p.Gly122Asp | p.G122D | A8MUP2 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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