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Gene: MESDC2 |
Gene summary for MESDC2 |
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Gene information | Species | Human | Gene symbol | MESDC2 | Gene ID | 23184 |
Gene name | mesoderm development LRP chaperone | |
Gene Alias | BOCA | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q14696 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23184 | MESDC2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.89e-27 | 5.06e-01 | 0.294 |
23184 | MESDC2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.60e-16 | 1.38e+00 | 0.3487 |
23184 | MESDC2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.09e-06 | 2.46e-01 | 0.281 |
23184 | MESDC2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.56e-16 | 3.47e-01 | 0.3859 |
23184 | MESDC2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.57e-07 | 3.22e-01 | 0.2585 |
23184 | MESDC2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.19e-14 | 2.67e-01 | 0.3005 |
23184 | MESDC2 | AEH-subject1 | Human | Endometrium | AEH | 1.75e-35 | -5.12e-01 | -0.3059 |
23184 | MESDC2 | AEH-subject2 | Human | Endometrium | AEH | 1.83e-30 | -5.12e-01 | -0.2525 |
23184 | MESDC2 | AEH-subject3 | Human | Endometrium | AEH | 1.16e-34 | -5.12e-01 | -0.2576 |
23184 | MESDC2 | AEH-subject4 | Human | Endometrium | AEH | 1.29e-23 | -5.12e-01 | -0.2657 |
23184 | MESDC2 | AEH-subject5 | Human | Endometrium | AEH | 1.16e-34 | -5.12e-01 | -0.2953 |
23184 | MESDC2 | EEC-subject1 | Human | Endometrium | EEC | 7.64e-34 | -5.12e-01 | -0.2682 |
23184 | MESDC2 | EEC-subject2 | Human | Endometrium | EEC | 1.45e-37 | -5.12e-01 | -0.2607 |
23184 | MESDC2 | EEC-subject3 | Human | Endometrium | EEC | 1.75e-35 | -5.12e-01 | -0.2525 |
23184 | MESDC2 | EEC-subject4 | Human | Endometrium | EEC | 4.51e-35 | -5.12e-01 | -0.2571 |
23184 | MESDC2 | EEC-subject5 | Human | Endometrium | EEC | 4.51e-35 | -5.12e-01 | -0.249 |
23184 | MESDC2 | GSM5276934 | Human | Endometrium | EEC | 7.64e-34 | -5.12e-01 | -0.0913 |
23184 | MESDC2 | GSM5276935 | Human | Endometrium | EEC | 6.74e-36 | -5.12e-01 | -0.123 |
23184 | MESDC2 | GSM5276937 | Human | Endometrium | EEC | 1.15e-28 | -5.12e-01 | -0.0897 |
23184 | MESDC2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.88e-25 | -5.12e-01 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MESDC2 | SNV | Missense_Mutation | c.458N>C | p.Gly153Ala | p.G153A | Q14696 | protein_coding | deleterious(0.05) | benign(0.041) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MESDC2 | SNV | Missense_Mutation | novel | c.274N>A | p.Asp92Asn | p.D92N | Q14696 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MESDC2 | SNV | Missense_Mutation | novel | c.365N>A | p.Gly122Glu | p.G122E | Q14696 | protein_coding | deleterious(0.05) | probably_damaging(0.986) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MESDC2 | SNV | Missense_Mutation | novel | c.296N>A | p.Ser99Asn | p.S99N | Q14696 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MESDC2 | SNV | Missense_Mutation | c.564N>T | p.Gln188His | p.Q188H | Q14696 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MESDC2 | SNV | Missense_Mutation | c.410N>T | p.Gln137Leu | p.Q137L | Q14696 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MESDC2 | SNV | Missense_Mutation | c.510N>G | p.Ile170Met | p.I170M | Q14696 | protein_coding | tolerated(0.06) | benign(0.262) | TCGA-AG-A00C-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
MESDC2 | SNV | Missense_Mutation | rs776756284 | c.373A>G | p.Thr125Ala | p.T125A | Q14696 | protein_coding | deleterious(0) | possibly_damaging(0.775) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
MESDC2 | deletion | Frame_Shift_Del | rs779080640 | c.632delN | p.Lys211ArgfsTer6 | p.K211Rfs*6 | Q14696 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
MESDC2 | deletion | Frame_Shift_Del | rs779080640 | c.632delN | p.Lys211ArgfsTer6 | p.K211Rfs*6 | Q14696 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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