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Gene: MESDC1 |
Gene summary for MESDC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MESDC1 | Gene ID | 59274 |
Gene name | talin rod domain containing 1 | |
Gene Alias | MESDC1 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001725 | UniProtAcc | Q9H1K6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59274 | MESDC1 | P1T-E | Human | Esophagus | ESCC | 1.45e-07 | 5.47e-01 | 0.0875 |
59274 | MESDC1 | P2T-E | Human | Esophagus | ESCC | 3.51e-18 | 2.63e-01 | 0.1177 |
59274 | MESDC1 | P4T-E | Human | Esophagus | ESCC | 8.72e-08 | 1.89e-01 | 0.1323 |
59274 | MESDC1 | P5T-E | Human | Esophagus | ESCC | 8.58e-07 | 2.18e-03 | 0.1327 |
59274 | MESDC1 | P8T-E | Human | Esophagus | ESCC | 4.74e-16 | 1.70e-01 | 0.0889 |
59274 | MESDC1 | P9T-E | Human | Esophagus | ESCC | 1.71e-12 | 3.07e-01 | 0.1131 |
59274 | MESDC1 | P10T-E | Human | Esophagus | ESCC | 6.83e-15 | 8.92e-02 | 0.116 |
59274 | MESDC1 | P12T-E | Human | Esophagus | ESCC | 3.84e-09 | 8.48e-02 | 0.1122 |
59274 | MESDC1 | P15T-E | Human | Esophagus | ESCC | 8.77e-06 | 1.90e-01 | 0.1149 |
59274 | MESDC1 | P16T-E | Human | Esophagus | ESCC | 1.79e-07 | 7.57e-02 | 0.1153 |
59274 | MESDC1 | P17T-E | Human | Esophagus | ESCC | 1.14e-03 | 1.19e-01 | 0.1278 |
59274 | MESDC1 | P20T-E | Human | Esophagus | ESCC | 2.02e-05 | 8.45e-03 | 0.1124 |
59274 | MESDC1 | P21T-E | Human | Esophagus | ESCC | 2.25e-12 | 5.65e-02 | 0.1617 |
59274 | MESDC1 | P22T-E | Human | Esophagus | ESCC | 6.41e-11 | 6.53e-03 | 0.1236 |
59274 | MESDC1 | P23T-E | Human | Esophagus | ESCC | 2.05e-10 | 1.86e-01 | 0.108 |
59274 | MESDC1 | P24T-E | Human | Esophagus | ESCC | 3.40e-09 | -1.10e-02 | 0.1287 |
59274 | MESDC1 | P26T-E | Human | Esophagus | ESCC | 1.33e-10 | 1.95e-01 | 0.1276 |
59274 | MESDC1 | P27T-E | Human | Esophagus | ESCC | 4.04e-06 | 6.67e-02 | 0.1055 |
59274 | MESDC1 | P28T-E | Human | Esophagus | ESCC | 4.59e-15 | 1.80e-01 | 0.1149 |
59274 | MESDC1 | P30T-E | Human | Esophagus | ESCC | 1.27e-06 | 3.87e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MESDC1 | SNV | Missense_Mutation | novel | c.1081N>T | p.Val361Leu | p.V361L | Q9H1K6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MESDC1 | SNV | Missense_Mutation | novel | c.983N>T | p.Asn328Ile | p.N328I | Q9H1K6 | protein_coding | deleterious(0.02) | benign(0.025) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MESDC1 | SNV | Missense_Mutation | novel | c.898N>A | p.Val300Met | p.V300M | Q9H1K6 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MESDC1 | SNV | Missense_Mutation | c.731G>T | p.Arg244Leu | p.R244L | Q9H1K6 | protein_coding | tolerated(0.15) | benign(0.301) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
MESDC1 | SNV | Missense_Mutation | novel | c.1066N>T | p.Val356Leu | p.V356L | Q9H1K6 | protein_coding | deleterious_low_confidence(0.03) | benign(0.086) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MESDC1 | SNV | Missense_Mutation | c.967N>G | p.Arg323Gly | p.R323G | Q9H1K6 | protein_coding | tolerated(0.06) | benign(0.424) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MESDC1 | SNV | Missense_Mutation | novel | c.997N>T | p.Val333Leu | p.V333L | Q9H1K6 | protein_coding | deleterious(0.01) | possibly_damaging(0.705) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MESDC1 | SNV | Missense_Mutation | novel | c.676N>C | p.Ser226Pro | p.S226P | Q9H1K6 | protein_coding | deleterious(0.04) | benign(0.201) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
MESDC1 | SNV | Missense_Mutation | novel | c.1069A>T | p.Asn357Tyr | p.N357Y | Q9H1K6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.731) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
MESDC1 | SNV | Missense_Mutation | novel | c.1079N>G | p.Ser360Cys | p.S360C | Q9H1K6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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