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Gene: MESD |
Gene summary for MESD |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MESD | Gene ID | 23184 |
| Gene name | mesoderm development LRP chaperone | |
| Gene Alias | BOCA | |
| Cytomap | 15q25.1 | |
| Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q14696 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23184 | MESD | LZE2D | Human | Esophagus | HGIN | 6.44e-06 | 6.32e-01 | 0.0642 |
| 23184 | MESD | LZE2T | Human | Esophagus | ESCC | 1.47e-14 | 1.34e+00 | 0.082 |
| 23184 | MESD | LZE3D | Human | Esophagus | HGIN | 8.88e-07 | 8.48e-01 | 0.0668 |
| 23184 | MESD | LZE4T | Human | Esophagus | ESCC | 8.08e-37 | 8.17e-01 | 0.0811 |
| 23184 | MESD | LZE5T | Human | Esophagus | ESCC | 4.24e-14 | 6.52e-01 | 0.0514 |
| 23184 | MESD | LZE7T | Human | Esophagus | ESCC | 7.39e-21 | 1.01e+00 | 0.0667 |
| 23184 | MESD | LZE8T | Human | Esophagus | ESCC | 9.50e-36 | 9.29e-01 | 0.067 |
| 23184 | MESD | LZE20T | Human | Esophagus | ESCC | 3.87e-19 | 5.17e-01 | 0.0662 |
| 23184 | MESD | LZE21D1 | Human | Esophagus | HGIN | 2.75e-06 | 6.78e-01 | 0.0632 |
| 23184 | MESD | LZE22D1 | Human | Esophagus | HGIN | 1.24e-04 | 2.38e-01 | 0.0595 |
| 23184 | MESD | LZE22T | Human | Esophagus | ESCC | 1.54e-17 | 7.78e-01 | 0.068 |
| 23184 | MESD | LZE24T | Human | Esophagus | ESCC | 2.92e-27 | 6.03e-01 | 0.0596 |
| 23184 | MESD | LZE22D3 | Human | Esophagus | HGIN | 4.92e-04 | 5.85e-01 | 0.0653 |
| 23184 | MESD | LZE21T | Human | Esophagus | ESCC | 2.11e-16 | 5.66e-01 | 0.0655 |
| 23184 | MESD | LZE6T | Human | Esophagus | ESCC | 2.36e-17 | 7.73e-01 | 0.0845 |
| 23184 | MESD | S014 | Human | Liver | HCC | 1.84e-50 | 1.75e+00 | 0.2254 |
| 23184 | MESD | S015 | Human | Liver | HCC | 5.79e-41 | 1.93e+00 | 0.2375 |
| 23184 | MESD | S016 | Human | Liver | HCC | 2.93e-59 | 1.95e+00 | 0.2243 |
| 23184 | MESD | S027 | Human | Liver | HCC | 1.72e-19 | 1.49e+00 | 0.2446 |
| 23184 | MESD | S028 | Human | Liver | HCC | 4.47e-46 | 1.61e+00 | 0.2503 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000645720 | Esophagus | HGIN | protein folding | 75/2587 | 212/18723 | 1.61e-15 | 3.86e-13 | 75 |
| GO:190382926 | Esophagus | HGIN | positive regulation of cellular protein localization | 75/2587 | 276/18723 | 3.19e-09 | 2.30e-07 | 75 |
| GO:190547518 | Esophagus | HGIN | regulation of protein localization to membrane | 43/2587 | 175/18723 | 9.45e-05 | 2.03e-03 | 43 |
| GO:190547718 | Esophagus | HGIN | positive regulation of protein localization to membrane | 26/2587 | 106/18723 | 2.17e-03 | 2.25e-02 | 26 |
| GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
| GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
| GO:000150316 | Esophagus | HGIN | ossification | 75/2587 | 408/18723 | 5.49e-03 | 4.49e-02 | 75 |
| GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
| GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
| GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
| GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
| GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
| GO:190547719 | Esophagus | ESCC | positive regulation of protein localization to membrane | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
| GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
| GO:190382922 | Liver | HCC | positive regulation of cellular protein localization | 199/7958 | 276/18723 | 1.15e-23 | 2.62e-21 | 199 |
| GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
| GO:190547511 | Liver | HCC | regulation of protein localization to membrane | 113/7958 | 175/18723 | 2.90e-09 | 7.78e-08 | 113 |
| GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
| GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
| GO:190547711 | Liver | HCC | positive regulation of protein localization to membrane | 68/7958 | 106/18723 | 5.50e-06 | 6.82e-05 | 68 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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