![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MEI1 |
Gene summary for MEI1 |
![]() |
Gene information | Species | Human | Gene symbol | MEI1 | Gene ID | 150365 |
Gene name | meiotic double-stranded break formation protein 1 | |
Gene Alias | HYDM3 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q4G0I1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150365 | MEI1 | CCI_3 | Human | Cervix | CC | 6.87e-34 | 1.54e+00 | 0.516 |
150365 | MEI1 | CCII_1 | Human | Cervix | CC | 1.61e-12 | 5.15e-01 | 0.3249 |
150365 | MEI1 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 8.74e-03 | 5.76e-01 | 0.1479 |
150365 | MEI1 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 1.61e-04 | 6.39e-01 | 0.1531 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEI1 | SNV | Missense_Mutation | rs764979273 | c.1148N>C | p.Ile383Thr | p.I383T | Q5TIA1 | protein_coding | tolerated(0.46) | benign(0) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
MEI1 | SNV | Missense_Mutation | c.2743N>T | p.Leu915Phe | p.L915F | Q5TIA1 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MEI1 | SNV | Missense_Mutation | c.2536A>C | p.Ile846Leu | p.I846L | Q5TIA1 | protein_coding | tolerated(0.06) | benign(0.107) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MEI1 | SNV | Missense_Mutation | novel | c.1166G>A | p.Gly389Asp | p.G389D | Q5TIA1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MEI1 | SNV | Missense_Mutation | rs767987047 | c.3203G>A | p.Arg1068Gln | p.R1068Q | Q5TIA1 | protein_coding | tolerated(0.83) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MEI1 | SNV | Missense_Mutation | rs779589520 | c.2063G>A | p.Arg688His | p.R688H | Q5TIA1 | protein_coding | deleterious(0.03) | benign(0.084) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MEI1 | SNV | Missense_Mutation | c.2459C>G | p.Ser820Cys | p.S820C | Q5TIA1 | protein_coding | deleterious(0.02) | possibly_damaging(0.729) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
MEI1 | SNV | Missense_Mutation | novel | c.1958N>T | p.Ser653Phe | p.S653F | Q5TIA1 | protein_coding | deleterious(0.01) | benign(0.264) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MEI1 | deletion | Frame_Shift_Del | c.3234_3246delNNNNNNNNNNNNN | p.Val1079ProfsTer12 | p.V1079Pfs*12 | Q5TIA1 | protein_coding | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |||
MEI1 | insertion | Nonsense_Mutation | novel | c.1531_1532insTTTCACTATGTTAGCCAGGATGGCTACGATCTCCTGA | p.Ala511ValfsTer5 | p.A511Vfs*5 | Q5TIA1 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |