![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MED11 |
Gene summary for MED11 |
![]() |
Gene information | Species | Human | Gene symbol | MED11 | Gene ID | 400569 |
Gene name | mediator complex subunit 11 | |
Gene Alias | HSPC296 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9P086 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
400569 | MED11 | LZE4T | Human | Esophagus | ESCC | 7.48e-09 | 2.33e-01 | 0.0811 |
400569 | MED11 | LZE5T | Human | Esophagus | ESCC | 1.85e-03 | 2.70e-01 | 0.0514 |
400569 | MED11 | LZE8T | Human | Esophagus | ESCC | 1.39e-04 | 1.35e-01 | 0.067 |
400569 | MED11 | LZE20T | Human | Esophagus | ESCC | 4.27e-03 | 1.21e-01 | 0.0662 |
400569 | MED11 | LZE22D1 | Human | Esophagus | HGIN | 1.10e-02 | 2.08e-01 | 0.0595 |
400569 | MED11 | LZE24T | Human | Esophagus | ESCC | 1.49e-16 | 3.84e-01 | 0.0596 |
400569 | MED11 | LZE21T | Human | Esophagus | ESCC | 2.39e-04 | 2.78e-01 | 0.0655 |
400569 | MED11 | LZE6T | Human | Esophagus | ESCC | 1.04e-07 | 3.31e-01 | 0.0845 |
400569 | MED11 | P1T-E | Human | Esophagus | ESCC | 5.89e-09 | 3.16e-01 | 0.0875 |
400569 | MED11 | P2T-E | Human | Esophagus | ESCC | 1.74e-14 | 2.95e-01 | 0.1177 |
400569 | MED11 | P4T-E | Human | Esophagus | ESCC | 3.48e-28 | 6.35e-01 | 0.1323 |
400569 | MED11 | P5T-E | Human | Esophagus | ESCC | 2.84e-10 | 2.48e-01 | 0.1327 |
400569 | MED11 | P8T-E | Human | Esophagus | ESCC | 4.96e-17 | 3.44e-01 | 0.0889 |
400569 | MED11 | P9T-E | Human | Esophagus | ESCC | 8.52e-14 | 2.90e-01 | 0.1131 |
400569 | MED11 | P10T-E | Human | Esophagus | ESCC | 5.85e-18 | 2.53e-01 | 0.116 |
400569 | MED11 | P11T-E | Human | Esophagus | ESCC | 1.65e-17 | 5.08e-01 | 0.1426 |
400569 | MED11 | P12T-E | Human | Esophagus | ESCC | 4.03e-25 | 4.47e-01 | 0.1122 |
400569 | MED11 | P15T-E | Human | Esophagus | ESCC | 2.02e-08 | 1.65e-01 | 0.1149 |
400569 | MED11 | P16T-E | Human | Esophagus | ESCC | 4.74e-21 | 3.55e-01 | 0.1153 |
400569 | MED11 | P17T-E | Human | Esophagus | ESCC | 7.46e-14 | 4.94e-01 | 0.1278 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED11 | SNV | Missense_Mutation | c.29N>T | p.Arg10Ile | p.R10I | Q9P086 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MED11 | SNV | Missense_Mutation | rs766639693 | c.257N>T | p.Ser86Leu | p.S86L | Q9P086 | protein_coding | tolerated(0.14) | benign(0.102) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MED11 | SNV | Missense_Mutation | rs766639693 | c.257N>T | p.Ser86Leu | p.S86L | Q9P086 | protein_coding | tolerated(0.14) | benign(0.102) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
MED11 | SNV | Missense_Mutation | novel | c.301N>A | p.Arg101Ser | p.R101S | Q9P086 | protein_coding | deleterious(0) | benign(0.395) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MED11 | SNV | Missense_Mutation | novel | c.254C>G | p.Ser85Cys | p.S85C | Q9P086 | protein_coding | tolerated(0.07) | benign(0.213) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
MED11 | SNV | Missense_Mutation | novel | c.301C>A | p.Arg101Ser | p.R101S | Q9P086 | protein_coding | deleterious(0) | benign(0.395) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MED11 | SNV | Missense_Mutation | novel | c.178N>A | p.Glu60Lys | p.E60K | Q9P086 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CV-7406-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MED11 | SNV | Missense_Mutation | rs559815092 | c.160N>A | p.Ala54Thr | p.A54T | Q9P086 | protein_coding | tolerated(0.28) | benign(0) | TCGA-ZG-A9MC-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
MED11 | SNV | Missense_Mutation | c.65G>A | p.Gly22Asp | p.G22D | Q9P086 | protein_coding | tolerated(0.18) | benign(0.049) | TCGA-ET-A4KN-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |