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Gene: MDP1 |
Gene summary for MDP1 |
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Gene information | Species | Human | Gene symbol | MDP1 | Gene ID | 145553 |
Gene name | magnesium dependent phosphatase 1 | |
Gene Alias | FN6PASE | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006040 | UniProtAcc | Q86V88 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
145553 | MDP1 | LZE4T | Human | Esophagus | ESCC | 2.18e-06 | 2.13e-01 | 0.0811 |
145553 | MDP1 | LZE5T | Human | Esophagus | ESCC | 1.57e-03 | 3.08e-01 | 0.0514 |
145553 | MDP1 | LZE7T | Human | Esophagus | ESCC | 6.13e-07 | 2.67e-01 | 0.0667 |
145553 | MDP1 | LZE8T | Human | Esophagus | ESCC | 9.77e-06 | 2.01e-01 | 0.067 |
145553 | MDP1 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.31e-01 | 0.0662 |
145553 | MDP1 | LZE24T | Human | Esophagus | ESCC | 1.47e-24 | 5.56e-01 | 0.0596 |
145553 | MDP1 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 3.22e-01 | 0.0655 |
145553 | MDP1 | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 1.65e-01 | 0.0875 |
145553 | MDP1 | P2T-E | Human | Esophagus | ESCC | 2.39e-24 | 3.95e-01 | 0.1177 |
145553 | MDP1 | P4T-E | Human | Esophagus | ESCC | 2.73e-41 | 7.94e-01 | 0.1323 |
145553 | MDP1 | P5T-E | Human | Esophagus | ESCC | 2.41e-29 | 4.90e-01 | 0.1327 |
145553 | MDP1 | P8T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.50e-01 | 0.0889 |
145553 | MDP1 | P9T-E | Human | Esophagus | ESCC | 1.75e-19 | 4.02e-01 | 0.1131 |
145553 | MDP1 | P10T-E | Human | Esophagus | ESCC | 2.78e-38 | 5.45e-01 | 0.116 |
145553 | MDP1 | P11T-E | Human | Esophagus | ESCC | 2.88e-23 | 7.16e-01 | 0.1426 |
145553 | MDP1 | P12T-E | Human | Esophagus | ESCC | 6.36e-70 | 1.02e+00 | 0.1122 |
145553 | MDP1 | P15T-E | Human | Esophagus | ESCC | 5.99e-45 | 7.90e-01 | 0.1149 |
145553 | MDP1 | P16T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.65e-01 | 0.1153 |
145553 | MDP1 | P17T-E | Human | Esophagus | ESCC | 3.52e-10 | 4.56e-01 | 0.1278 |
145553 | MDP1 | P19T-E | Human | Esophagus | ESCC | 2.95e-08 | 4.63e-01 | 0.1662 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MDP1 | SNV | Missense_Mutation | c.100N>A | p.Asp34Asn | p.D34N | Q86V88 | protein_coding | tolerated(0.37) | benign(0.015) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MDP1 | SNV | Missense_Mutation | c.205N>C | p.Ser69Pro | p.S69P | Q86V88 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD | |
MDP1 | SNV | Missense_Mutation | c.421A>G | p.Ile141Val | p.I141V | Q86V88 | protein_coding | tolerated(1) | benign(0) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MDP1 | SNV | Missense_Mutation | c.251N>G | p.Phe84Cys | p.F84C | Q86V88 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MDP1 | SNV | Missense_Mutation | rs778668678 | c.354N>A | p.Met118Ile | p.M118I | Q86V88 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MDP1 | SNV | Missense_Mutation | c.370N>C | p.Glu124Gln | p.E124Q | Q86V88 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A7X3-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
MDP1 | SNV | Missense_Mutation | c.360C>A | p.Phe120Leu | p.F120L | Q86V88 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MDP1 | SNV | Missense_Mutation | novel | c.274C>A | p.His92Asn | p.H92N | Q86V88 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MDP1 | SNV | Missense_Mutation | novel | c.513G>T | p.Glu171Asp | p.E171D | Q86V88 | protein_coding | tolerated_low_confidence(0.64) | benign(0.015) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MDP1 | SNV | Missense_Mutation | c.452N>A | p.Ser151Asn | p.S151N | Q86V88 | protein_coding | tolerated(0.43) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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