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Gene: MCTP1 |
Gene summary for MCTP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MCTP1 | Gene ID | 79772 |
| Gene name | multiple C2 and transmembrane domain containing 1 | |
| Gene Alias | MCTP1 | |
| Cytomap | 5q15 | |
| Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q6DN14 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79772 | MCTP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.13e-05 | 2.20e-01 | -0.1088 |
| 79772 | MCTP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.59e-09 | 1.99e-01 | -0.1954 |
| 79772 | MCTP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.26e-02 | 1.14e-01 | -0.1464 |
| 79772 | MCTP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.20e-30 | 4.01e+00 | 0.0131 |
| 79772 | MCTP1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.22e-05 | 2.90e-01 | 0.0112 |
| 79772 | MCTP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.17e-05 | 2.17e-01 | 0.0588 |
| 79772 | MCTP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.61e-11 | 3.91e-01 | 0.294 |
| 79772 | MCTP1 | CRC-1-8810 | Human | Colorectum | CRC | 1.92e-10 | 4.97e-01 | 0.6257 |
| 79772 | MCTP1 | LZE2T | Human | Esophagus | ESCC | 4.35e-02 | 3.44e-01 | 0.082 |
| 79772 | MCTP1 | LZE5T | Human | Esophagus | ESCC | 7.82e-04 | 2.62e-01 | 0.0514 |
| 79772 | MCTP1 | LZE8T | Human | Esophagus | ESCC | 3.86e-06 | 2.57e-01 | 0.067 |
| 79772 | MCTP1 | LZE6T | Human | Esophagus | ESCC | 6.85e-04 | 2.78e-01 | 0.0845 |
| 79772 | MCTP1 | P5T-E | Human | Esophagus | ESCC | 1.87e-05 | 2.00e-01 | 0.1327 |
| 79772 | MCTP1 | P8T-E | Human | Esophagus | ESCC | 6.24e-05 | 1.76e-01 | 0.0889 |
| 79772 | MCTP1 | P12T-E | Human | Esophagus | ESCC | 2.36e-02 | 1.44e-01 | 0.1122 |
| 79772 | MCTP1 | P15T-E | Human | Esophagus | ESCC | 2.53e-05 | 1.74e-01 | 0.1149 |
| 79772 | MCTP1 | P16T-E | Human | Esophagus | ESCC | 5.60e-03 | 9.80e-02 | 0.1153 |
| 79772 | MCTP1 | P20T-E | Human | Esophagus | ESCC | 4.20e-08 | 2.20e-01 | 0.1124 |
| 79772 | MCTP1 | P22T-E | Human | Esophagus | ESCC | 3.86e-11 | 2.84e-01 | 0.1236 |
| 79772 | MCTP1 | P31T-E | Human | Esophagus | ESCC | 5.16e-05 | 1.09e-01 | 0.1251 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
| GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
| GO:1902882 | Colorectum | AD | regulation of response to oxidative stress | 34/3918 | 98/18723 | 1.09e-03 | 1.01e-02 | 34 |
| GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
| GO:19028821 | Colorectum | SER | regulation of response to oxidative stress | 28/2897 | 98/18723 | 6.88e-04 | 9.15e-03 | 28 |
| GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
| GO:00301001 | Colorectum | SER | regulation of endocytosis | 48/2897 | 211/18723 | 3.29e-03 | 2.82e-02 | 48 |
| GO:00069792 | Colorectum | MSS | response to oxidative stress | 128/3467 | 446/18723 | 7.65e-08 | 3.81e-06 | 128 |
| GO:00301002 | Colorectum | MSS | regulation of endocytosis | 63/3467 | 211/18723 | 4.05e-05 | 7.66e-04 | 63 |
| GO:19028822 | Colorectum | MSS | regulation of response to oxidative stress | 31/3467 | 98/18723 | 1.22e-03 | 1.18e-02 | 31 |
| GO:00510511 | Colorectum | MSS | negative regulation of transport | 110/3467 | 470/18723 | 4.20e-03 | 3.04e-02 | 110 |
| GO:00069795 | Colorectum | CRC | response to oxidative stress | 73/2078 | 446/18723 | 4.31e-04 | 6.34e-03 | 73 |
| GO:19028825 | Colorectum | CRC | regulation of response to oxidative stress | 22/2078 | 98/18723 | 9.29e-04 | 1.14e-02 | 22 |
| GO:00301004 | Colorectum | CRC | regulation of endocytosis | 39/2078 | 211/18723 | 9.51e-04 | 1.15e-02 | 39 |
| GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
| GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
| GO:00230611 | Colorectum | CRC | signal release | 72/2078 | 463/18723 | 1.95e-03 | 1.96e-02 | 72 |
| GO:00510513 | Colorectum | CRC | negative regulation of transport | 71/2078 | 470/18723 | 4.33e-03 | 3.47e-02 | 71 |
| GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
| GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MCTP1 | SNV | Missense_Mutation | rs772947808 | c.903N>G | p.Ile301Met | p.I301M | Q6DN14 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-A2-A25C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
| MCTP1 | SNV | Missense_Mutation | novel | c.488N>T | p.Ser163Leu | p.S163L | Q6DN14 | protein_coding | tolerated(0.06) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| MCTP1 | SNV | Missense_Mutation | novel | c.1754N>A | p.Thr585Lys | p.T585K | Q6DN14 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-AC-A2QH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| MCTP1 | SNV | Missense_Mutation | c.1185N>A | p.Met395Ile | p.M395I | Q6DN14 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| MCTP1 | SNV | Missense_Mutation | c.524N>T | p.Arg175Met | p.R175M | Q6DN14 | protein_coding | tolerated_low_confidence(0.19) | benign(0.436) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| MCTP1 | SNV | Missense_Mutation | novel | c.2758G>A | p.Ala920Thr | p.A920T | Q6DN14 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MCTP1 | SNV | Missense_Mutation | c.2707G>A | p.Glu903Lys | p.E903K | Q6DN14 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| MCTP1 | SNV | Missense_Mutation | novel | c.1821G>T | p.Glu607Asp | p.E607D | Q6DN14 | protein_coding | tolerated(0.43) | benign(0.039) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MCTP1 | SNV | Missense_Mutation | novel | c.1142N>G | p.Leu381Arg | p.L381R | Q6DN14 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| MCTP1 | SNV | Missense_Mutation | novel | c.754G>A | p.Glu252Lys | p.E252K | Q6DN14 | protein_coding | tolerated(0.09) | benign(0.038) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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