Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MAVS

Gene summary for MAVS

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MAVS

Gene ID

57506

Gene namemitochondrial antiviral signaling protein
Gene AliasCARDIF
Cytomap20p13
Gene Typeprotein-coding
GO ID

GO:0001816

UniProtAcc

Q7Z434


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57506MAVSHTA11_2487_2000001011HumanColorectumSER6.18e-076.14e-01-0.1808
57506MAVSHTA11_1938_2000001011HumanColorectumAD3.49e-055.62e-01-0.0811
57506MAVSHTA11_347_2000001011HumanColorectumAD9.59e-279.03e-01-0.1954
57506MAVSHTA11_411_2000001011HumanColorectumSER1.32e-027.91e-01-0.2602
57506MAVSHTA11_3361_2000001011HumanColorectumAD5.34e-076.83e-01-0.1207
57506MAVSHTA11_83_2000001011HumanColorectumSER5.76e-129.28e-01-0.1526
57506MAVSHTA11_696_2000001011HumanColorectumAD9.58e-229.12e-01-0.1464
57506MAVSHTA11_866_2000001011HumanColorectumAD6.46e-105.31e-01-0.1001
57506MAVSHTA11_1391_2000001011HumanColorectumAD1.81e-096.82e-01-0.059
57506MAVSHTA11_2992_2000001011HumanColorectumSER5.22e-036.74e-01-0.1706
57506MAVSHTA11_546_2000001011HumanColorectumAD8.52e-046.09e-01-0.0842
57506MAVSHTA11_866_3004761011HumanColorectumAD9.37e-033.96e-010.096
57506MAVSHTA11_9408_2000001011HumanColorectumAD8.16e-032.17e-010.0451
57506MAVSHTA11_7663_2000001011HumanColorectumSER8.30e-046.18e-010.0131
57506MAVSHTA11_99999973899_84307HumanColorectumMSS4.42e-025.61e-010.2585
57506MAVSHTA11_99999974143_84620HumanColorectumMSS1.06e-084.61e-010.3005
57506MAVSA002-C-010HumanColorectumFAP7.67e-04-3.06e-010.242
57506MAVSA015-C-203HumanColorectumFAP1.62e-14-1.09e-01-0.1294
57506MAVSA002-C-201HumanColorectumFAP6.04e-05-1.91e-010.0324
57506MAVSA001-C-108HumanColorectumFAP9.92e-10-2.04e-01-0.0272
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016032ColorectumADviral process168/3918415/187234.67e-203.66e-17168
GO:1903829ColorectumADpositive regulation of cellular protein localization110/3918276/187234.58e-138.44e-11110
GO:0019058ColorectumADviral life cycle119/3918317/187236.18e-128.23e-10119
GO:0072594ColorectumADestablishment of protein localization to organelle148/3918422/187237.95e-121.04e-09148
GO:1904951ColorectumADpositive regulation of establishment of protein localization112/3918319/187232.55e-091.80e-07112
GO:0051222ColorectumADpositive regulation of protein transport106/3918303/187238.45e-095.08e-07106
GO:0006913ColorectumADnucleocytoplasmic transport102/3918301/187231.00e-074.85e-06102
GO:0051169ColorectumADnuclear transport102/3918301/187231.00e-074.85e-06102
GO:1900180ColorectumADregulation of protein localization to nucleus55/3918136/187231.70e-077.34e-0655
GO:0090316ColorectumADpositive regulation of intracellular protein transport62/3918160/187231.82e-077.79e-0662
GO:0032388ColorectumADpositive regulation of intracellular transport74/3918202/187231.83e-077.80e-0674
GO:0032386ColorectumADregulation of intracellular transport109/3918337/187235.33e-071.95e-05109
GO:0033157ColorectumADregulation of intracellular protein transport80/3918229/187235.81e-072.09e-0580
GO:1900182ColorectumADpositive regulation of protein localization to nucleus38/391887/187231.43e-064.52e-0538
GO:0019079ColorectumADviral genome replication51/3918131/187231.83e-065.51e-0551
GO:0034504ColorectumADprotein localization to nucleus94/3918290/187232.83e-068.09e-0594
GO:0050792ColorectumADregulation of viral process59/3918164/187235.95e-061.52e-0459
GO:0046822ColorectumADregulation of nucleocytoplasmic transport41/3918106/187232.17e-054.33e-0441
GO:0046824ColorectumADpositive regulation of nucleocytoplasmic transport27/391862/187234.91e-058.43e-0427
GO:0017038ColorectumADprotein import67/3918206/187236.34e-051.05e-0367
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05171ColorectumADCoronavirus disease - COVID-19113/2092232/84659.90e-162.55e-141.63e-14113
hsa05160ColorectumADHepatitis C54/2092157/84653.87e-031.96e-021.25e-0254
hsa051711ColorectumADCoronavirus disease - COVID-19113/2092232/84659.90e-162.55e-141.63e-14113
hsa051601ColorectumADHepatitis C54/2092157/84653.87e-031.96e-021.25e-0254
hsa051712ColorectumSERCoronavirus disease - COVID-1998/1580232/84653.33e-178.50e-166.17e-1698
hsa051713ColorectumSERCoronavirus disease - COVID-1998/1580232/84653.33e-178.50e-166.17e-1698
hsa051714ColorectumMSSCoronavirus disease - COVID-19108/1875232/84656.50e-171.67e-151.03e-15108
hsa051602ColorectumMSSHepatitis C52/1875157/84659.29e-045.58e-033.42e-0352
hsa05169ColorectumMSSEpstein-Barr virus infection63/1875202/84651.63e-038.98e-035.50e-0363
hsa05161ColorectumMSSHepatitis B48/1875162/84651.53e-024.93e-023.02e-0248
hsa051715ColorectumMSSCoronavirus disease - COVID-19108/1875232/84656.50e-171.67e-151.03e-15108
hsa051603ColorectumMSSHepatitis C52/1875157/84659.29e-045.58e-033.42e-0352
hsa051691ColorectumMSSEpstein-Barr virus infection63/1875202/84651.63e-038.98e-035.50e-0363
hsa051611ColorectumMSSHepatitis B48/1875162/84651.53e-024.93e-023.02e-0248
hsa051718ColorectumFAPCoronavirus disease - COVID-1978/1404232/84659.94e-111.11e-086.73e-0978
hsa051719ColorectumFAPCoronavirus disease - COVID-1978/1404232/84659.94e-111.11e-086.73e-0978
hsa0517110ColorectumCRCCoronavirus disease - COVID-1974/1091232/84651.66e-142.78e-121.88e-1274
hsa0517111ColorectumCRCCoronavirus disease - COVID-1974/1091232/84651.66e-142.78e-121.88e-1274
hsa05169210EsophagusESCCEpstein-Barr virus infection151/4205202/84651.55e-133.45e-121.77e-12151
hsa0516425EsophagusESCCInfluenza A122/4205171/84655.01e-094.79e-082.45e-08122
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MAVSSNVMissense_Mutationnovelc.967C>Ap.Pro323Thrp.P323TQ7Z434protein_codingdeleterious(0.02)benign(0.047)TCGA-A2-A0CP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
MAVSSNVMissense_Mutationnovelc.841N>Gp.Ile281Valp.I281VQ7Z434protein_codingtolerated(0.1)benign(0)TCGA-A2-A0YM-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MAVSSNVMissense_Mutationrs762014329c.1460N>Tp.Ala487Valp.A487VQ7Z434protein_codingtolerated(0.18)benign(0.087)TCGA-AC-A62X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MAVSSNVMissense_Mutationnovelc.1249G>Cp.Glu417Glnp.E417QQ7Z434protein_codingdeleterious(0.02)possibly_damaging(0.728)TCGA-E9-A3QA-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MAVSSNVMissense_Mutationnovelc.1216N>Cp.Asp406Hisp.D406HQ7Z434protein_codingdeleterious(0)probably_damaging(0.958)TCGA-LL-A5YO-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
MAVSinsertionFrame_Shift_Insnovelc.965_966insCCCTCAGAAATATATAGTTGTCCATCTGp.Ser324GlnfsTer15p.S324Qfs*15Q7Z434protein_codingTCGA-A2-A0CP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
MAVSSNVMissense_Mutationc.545N>Gp.Ser182Cysp.S182CQ7Z434protein_codingdeleterious(0.04)possibly_damaging(0.826)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
MAVSSNVMissense_Mutationc.1438N>Cp.Glu480Glnp.E480QQ7Z434protein_codingtolerated(0.22)possibly_damaging(0.605)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
MAVSSNVMissense_Mutationnovelc.835N>Ap.Glu279Lysp.E279KQ7Z434protein_codingtolerated(0.33)benign(0.02)TCGA-AA-3994-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapycapecitabineCR
MAVSSNVMissense_Mutationc.1459N>Ap.Ala487Thrp.A487TQ7Z434protein_codingtolerated(0.27)benign(0.034)TCGA-AZ-4615-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapyxelodaPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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