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Gene: MATN2 |
Gene summary for MATN2 |
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Gene information | Species | Human | Gene symbol | MATN2 | Gene ID | 4147 |
Gene name | matrilin 2 | |
Gene Alias | MATN2 | |
Cytomap | 8q22.1-q22.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O00339 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4147 | MATN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.07e-03 | 2.42e-01 | -0.0811 |
4147 | MATN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.91e-07 | 4.27e-01 | -0.1088 |
4147 | MATN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.21e-19 | 5.91e-01 | -0.1954 |
4147 | MATN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.64e-07 | -2.56e-01 | 0.294 |
4147 | MATN2 | A002-C-010 | Human | Colorectum | FAP | 1.56e-11 | -2.79e-01 | 0.242 |
4147 | MATN2 | A015-C-203 | Human | Colorectum | FAP | 1.23e-10 | -2.67e-01 | -0.1294 |
4147 | MATN2 | A002-C-203 | Human | Colorectum | FAP | 3.32e-08 | -2.50e-01 | 0.2786 |
4147 | MATN2 | A002-C-021 | Human | Colorectum | FAP | 1.60e-02 | -2.46e-01 | 0.1171 |
4147 | MATN2 | A002-C-205 | Human | Colorectum | FAP | 3.76e-07 | -3.03e-01 | -0.1236 |
4147 | MATN2 | A001-C-104 | Human | Colorectum | FAP | 5.35e-03 | -1.74e-01 | 0.0184 |
4147 | MATN2 | A015-C-106 | Human | Colorectum | FAP | 6.82e-07 | -2.23e-01 | -0.0511 |
4147 | MATN2 | A015-C-104 | Human | Colorectum | FAP | 1.40e-10 | -2.73e-01 | -0.1899 |
4147 | MATN2 | A001-C-014 | Human | Colorectum | FAP | 1.11e-05 | -2.15e-01 | 0.0135 |
4147 | MATN2 | A002-C-016 | Human | Colorectum | FAP | 6.12e-09 | -2.41e-01 | 0.0521 |
4147 | MATN2 | A001-C-203 | Human | Colorectum | FAP | 1.02e-02 | -1.01e-01 | -0.0481 |
4147 | MATN2 | A002-C-116 | Human | Colorectum | FAP | 8.81e-10 | -2.16e-01 | -0.0452 |
4147 | MATN2 | F034 | Human | Colorectum | FAP | 6.40e-08 | -2.35e-01 | -0.0665 |
4147 | MATN2 | CRC-1-8810 | Human | Colorectum | CRC | 9.73e-08 | -2.32e-01 | 0.6257 |
4147 | MATN2 | LZE4T | Human | Esophagus | ESCC | 1.40e-27 | 1.46e+00 | 0.0811 |
4147 | MATN2 | LZE8T | Human | Esophagus | ESCC | 6.20e-03 | -2.69e-02 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MATN2 | SNV | Missense_Mutation | c.64G>A | p.Glu22Lys | p.E22K | O00339 | protein_coding | tolerated(0.69) | benign(0.012) | TCGA-A2-A0YC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD | |
MATN2 | SNV | Missense_Mutation | c.1960N>C | p.Ile654Leu | p.I654L | O00339 | protein_coding | tolerated(0.65) | benign(0) | TCGA-A2-A1FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Arimidex | SD | |
MATN2 | SNV | Missense_Mutation | c.1343N>T | p.Ala448Val | p.A448V | O00339 | protein_coding | tolerated(0.1) | probably_damaging(0.964) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MATN2 | SNV | Missense_Mutation | c.318N>T | p.Lys106Asn | p.K106N | O00339 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MATN2 | SNV | Missense_Mutation | c.327N>G | p.Phe109Leu | p.F109L | O00339 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MATN2 | SNV | Missense_Mutation | c.156G>T | p.Glu52Asp | p.E52D | O00339 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MATN2 | SNV | Missense_Mutation | c.64N>A | p.Glu22Lys | p.E22K | O00339 | protein_coding | tolerated(0.69) | benign(0.012) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
MATN2 | SNV | Missense_Mutation | rs199768448 | c.713N>T | p.Thr238Met | p.T238M | O00339 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-BH-A1EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MATN2 | SNV | Missense_Mutation | c.1616N>T | p.Ser539Leu | p.S539L | O00339 | protein_coding | tolerated(0.78) | benign(0) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
MATN2 | SNV | Missense_Mutation | novel | c.375N>C | p.Lys125Asn | p.K125N | O00339 | protein_coding | tolerated(0.41) | probably_damaging(0.932) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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