Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MARCHF7

Gene summary for MARCHF7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MARCHF7

Gene ID

64844

Gene namemembrane associated ring-CH-type finger 7
Gene AliasAXO
Cytomap2q24.2
Gene Typeprotein-coding
GO ID

GO:0000209

UniProtAcc

B7ZAR7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
64844MARCHF7HTA11_3410_2000001011HumanColorectumAD2.54e-082.08e-010.0155
64844MARCHF7HTA11_2487_2000001011HumanColorectumSER1.32e-082.58e-01-0.1808
64844MARCHF7HTA11_2951_2000001011HumanColorectumAD3.40e-021.93e-010.0216
64844MARCHF7HTA11_1938_2000001011HumanColorectumAD1.06e-195.17e-01-0.0811
64844MARCHF7HTA11_78_2000001011HumanColorectumAD1.18e-194.85e-01-0.1088
64844MARCHF7HTA11_347_2000001011HumanColorectumAD1.95e-386.45e-01-0.1954
64844MARCHF7HTA11_411_2000001011HumanColorectumSER1.20e-075.69e-01-0.2602
64844MARCHF7HTA11_2112_2000001011HumanColorectumSER1.50e-044.80e-01-0.2196
64844MARCHF7HTA11_3361_2000001011HumanColorectumAD2.57e-072.24e-01-0.1207
64844MARCHF7HTA11_83_2000001011HumanColorectumSER4.13e-103.09e-01-0.1526
64844MARCHF7HTA11_696_2000001011HumanColorectumAD3.84e-224.12e-01-0.1464
64844MARCHF7HTA11_866_2000001011HumanColorectumAD2.11e-213.91e-01-0.1001
64844MARCHF7HTA11_1391_2000001011HumanColorectumAD4.56e-174.83e-01-0.059
64844MARCHF7HTA11_2992_2000001011HumanColorectumSER1.94e-063.10e-01-0.1706
64844MARCHF7HTA11_5216_2000001011HumanColorectumSER3.22e-053.08e-01-0.1462
64844MARCHF7HTA11_546_2000001011HumanColorectumAD2.76e-073.18e-01-0.0842
64844MARCHF7HTA11_7862_2000001011HumanColorectumAD1.12e-063.39e-01-0.0179
64844MARCHF7HTA11_866_3004761011HumanColorectumAD1.67e-102.45e-010.096
64844MARCHF7HTA11_4255_2000001011HumanColorectumSER3.34e-042.80e-010.0446
64844MARCHF7HTA11_8622_2000001021HumanColorectumSER6.14e-042.26e-010.0528
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0042176ColorectumADregulation of protein catabolic process160/3918391/187231.06e-197.34e-17160
GO:1903362ColorectumADregulation of cellular protein catabolic process109/3918255/187232.14e-156.08e-13109
GO:0010498ColorectumADproteasomal protein catabolic process174/3918490/187233.18e-147.66e-12174
GO:0009895ColorectumADnegative regulation of catabolic process124/3918320/187231.66e-133.35e-11124
GO:1903050ColorectumADregulation of proteolysis involved in cellular protein catabolic process92/3918221/187232.04e-123.19e-1092
GO:0031330ColorectumADnegative regulation of cellular catabolic process104/3918262/187232.66e-123.96e-10104
GO:0097193ColorectumADintrinsic apoptotic signaling pathway108/3918288/187236.25e-116.41e-09108
GO:0031647ColorectumADregulation of protein stability108/3918298/187236.33e-105.08e-08108
GO:0042177ColorectumADnegative regulation of protein catabolic process55/3918121/187231.19e-098.85e-0855
GO:0061136ColorectumADregulation of proteasomal protein catabolic process75/3918187/187231.65e-091.20e-0775
GO:1903363ColorectumADnegative regulation of cellular protein catabolic process39/391875/187232.69e-091.87e-0739
GO:2001242ColorectumADregulation of intrinsic apoptotic signaling pathway67/3918164/187234.94e-093.16e-0767
GO:2001233ColorectumADregulation of apoptotic signaling pathway119/3918356/187232.14e-081.21e-06119
GO:0050821ColorectumADprotein stabilization73/3918191/187233.02e-081.64e-0673
GO:1903320ColorectumADregulation of protein modification by small protein conjugation or removal86/3918242/187239.43e-084.65e-0686
GO:1903051ColorectumADnegative regulation of proteolysis involved in cellular protein catabolic process31/391864/187238.71e-072.98e-0531
GO:0031396ColorectumADregulation of protein ubiquitination72/3918210/187234.50e-061.21e-0472
GO:0000209ColorectumADprotein polyubiquitination78/3918236/187238.71e-062.06e-0478
GO:0072331ColorectumADsignal transduction by p53 class mediator58/3918163/187231.04e-052.40e-0458
GO:2001234ColorectumADnegative regulation of apoptotic signaling pathway74/3918224/187231.49e-053.18e-0474
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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