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Gene: MARCHF6 |
Gene summary for MARCHF6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MARCHF6 | Gene ID | 10299 |
| Gene name | membrane associated ring-CH-type finger 6 | |
| Gene Alias | DOA10 | |
| Cytomap | 5p15.2 | |
| Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | O60337 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10299 | MARCHF6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.38e-20 | 3.81e-01 | 0.0155 |
| 10299 | MARCHF6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.04e-35 | 7.77e-01 | -0.1808 |
| 10299 | MARCHF6 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 3.08e-01 | 0.0216 |
| 10299 | MARCHF6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.66e-36 | 9.32e-01 | -0.0811 |
| 10299 | MARCHF6 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.21e-44 | 1.12e+00 | -0.1088 |
| 10299 | MARCHF6 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.36e-80 | 1.21e+00 | -0.1954 |
| 10299 | MARCHF6 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.89e-14 | 1.00e+00 | -0.2602 |
| 10299 | MARCHF6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.77e-16 | 7.74e-01 | -0.2196 |
| 10299 | MARCHF6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.74e-18 | 5.11e-01 | -0.1207 |
| 10299 | MARCHF6 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.07e-20 | 5.74e-01 | -0.1526 |
| 10299 | MARCHF6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.38e-32 | 5.86e-01 | -0.1464 |
| 10299 | MARCHF6 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.87e-46 | 6.84e-01 | -0.1001 |
| 10299 | MARCHF6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.05e-35 | 7.67e-01 | -0.059 |
| 10299 | MARCHF6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.54e-11 | 4.85e-01 | -0.1706 |
| 10299 | MARCHF6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.50e-18 | 7.16e-01 | -0.2061 |
| 10299 | MARCHF6 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.35e-17 | 7.98e-01 | -0.1462 |
| 10299 | MARCHF6 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.57e-20 | 5.67e-01 | -0.0842 |
| 10299 | MARCHF6 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.78e-05 | 3.68e-01 | -0.00410000000000005 |
| 10299 | MARCHF6 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.05e-17 | 5.56e-01 | -0.0179 |
| 10299 | MARCHF6 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.61e-35 | 6.73e-01 | 0.096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
| GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
| GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
| GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
| GO:0070936 | Colorectum | AD | protein K48-linked ubiquitination | 27/3918 | 65/18723 | 1.31e-04 | 1.88e-03 | 27 |
| GO:0036503 | Colorectum | AD | ERAD pathway | 34/3918 | 107/18723 | 5.57e-03 | 3.63e-02 | 34 |
| GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
| GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
| GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
| GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
| GO:00365031 | Colorectum | SER | ERAD pathway | 28/2897 | 107/18723 | 2.92e-03 | 2.59e-02 | 28 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
| hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
| hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
| hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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