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Gene: MARCHF5 |
Gene summary for MARCHF5 |
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Gene information | Species | Human | Gene symbol | MARCHF5 | Gene ID | 54708 |
Gene name | membrane associated ring-CH-type finger 5 | |
Gene Alias | MARCH-V | |
Cytomap | 10q23.32-q23.33 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9NX47 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54708 | MARCHF5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.24e-04 | 2.21e-01 | -0.0811 |
54708 | MARCHF5 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.20e-06 | 1.76e-01 | -0.1088 |
54708 | MARCHF5 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.42e-16 | 3.40e-01 | -0.1954 |
54708 | MARCHF5 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 2.94e-01 | -0.2602 |
54708 | MARCHF5 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.35e-06 | 2.18e-01 | -0.1526 |
54708 | MARCHF5 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.46e-07 | 1.82e-01 | -0.1464 |
54708 | MARCHF5 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.28e-10 | 2.40e-01 | -0.1001 |
54708 | MARCHF5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.86e-09 | 3.15e-01 | -0.059 |
54708 | MARCHF5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 2.63e-01 | -0.1706 |
54708 | MARCHF5 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.17e-02 | 1.36e-01 | -0.0842 |
54708 | MARCHF5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 2.52e-01 | -0.0179 |
54708 | MARCHF5 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.76e-05 | 1.54e-01 | 0.096 |
54708 | MARCHF5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.11e-07 | 2.39e-01 | 0.0338 |
54708 | MARCHF5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.40e-09 | 2.24e-01 | 0.0674 |
54708 | MARCHF5 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.39e-03 | 2.90e-01 | -0.0124 |
54708 | MARCHF5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.09e-05 | 1.94e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010821 | Colorectum | AD | regulation of mitochondrion organization | 57/3918 | 144/18723 | 2.43e-07 | 9.92e-06 | 57 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0010822 | Colorectum | AD | positive regulation of mitochondrion organization | 32/3918 | 74/18723 | 1.22e-05 | 2.68e-04 | 32 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0051865 | Colorectum | AD | protein autoubiquitination | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:00108211 | Colorectum | SER | regulation of mitochondrion organization | 48/2897 | 144/18723 | 7.51e-08 | 4.70e-06 | 48 |
GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
GO:00108221 | Colorectum | SER | positive regulation of mitochondrion organization | 27/2897 | 74/18723 | 7.79e-06 | 2.67e-04 | 27 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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