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Gene: MARCH3 |
Gene summary for MARCH3 |
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Gene information | Species | Human | Gene symbol | MARCH3 | Gene ID | 115123 |
Gene name | membrane associated ring-CH-type finger 3 | |
Gene Alias | MARCH-III | |
Cytomap | 5q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q86UD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115123 | MARCH3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.79e-44 | -1.01e+00 | 0.0155 |
115123 | MARCH3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.88e-27 | -1.01e+00 | -0.1808 |
115123 | MARCH3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.02e-07 | -1.01e+00 | 0.0216 |
115123 | MARCH3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.98e-21 | -1.01e+00 | -0.0811 |
115123 | MARCH3 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.66e-32 | -1.01e+00 | -0.1088 |
115123 | MARCH3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.82e-47 | -1.01e+00 | -0.1954 |
115123 | MARCH3 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.28e-05 | -1.01e+00 | -0.2602 |
115123 | MARCH3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.81e-06 | -1.01e+00 | -0.2196 |
115123 | MARCH3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.59e-22 | -1.01e+00 | -0.1207 |
115123 | MARCH3 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.54e-18 | -1.01e+00 | -0.1526 |
115123 | MARCH3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.40e-59 | -1.01e+00 | -0.1464 |
115123 | MARCH3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.41e-57 | -1.01e+00 | -0.1001 |
115123 | MARCH3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.61e-36 | -1.01e+00 | -0.059 |
115123 | MARCH3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.79e-09 | -1.01e+00 | -0.1706 |
115123 | MARCH3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.23e-10 | -1.01e+00 | -0.2061 |
115123 | MARCH3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.02e-07 | -1.01e+00 | -0.1462 |
115123 | MARCH3 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.67e-16 | -1.01e+00 | -0.0842 |
115123 | MARCH3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.28e-05 | -1.01e+00 | -0.00410000000000005 |
115123 | MARCH3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.93e-13 | -1.01e+00 | -0.0179 |
115123 | MARCH3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.70e-39 | -1.01e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARCH3 | SNV | Missense_Mutation | novel | c.551N>C | p.Gly184Ala | p.G184A | Q86UD3 | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MARCH3 | SNV | Missense_Mutation | c.13N>G | p.Arg5Gly | p.R5G | Q86UD3 | protein_coding | tolerated_low_confidence(0.51) | benign(0.001) | TCGA-VS-A957-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MARCH3 | SNV | Missense_Mutation | rs548204139 | c.292C>T | p.Arg98Trp | p.R98W | Q86UD3 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
MARCH3 | SNV | Missense_Mutation | rs759245490 | c.644G>A | p.Arg215His | p.R215H | Q86UD3 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-QG-A5YX-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
MARCH3 | SNV | Missense_Mutation | rs762900876 | c.370N>T | p.Arg124Cys | p.R124C | Q86UD3 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCH3 | SNV | Missense_Mutation | novel | c.243N>T | p.Glu81Asp | p.E81D | Q86UD3 | protein_coding | tolerated(0.08) | benign(0.409) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCH3 | SNV | Missense_Mutation | novel | c.592N>C | p.Phe198Leu | p.F198L | Q86UD3 | protein_coding | tolerated(0.91) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MARCH3 | SNV | Missense_Mutation | novel | c.124N>G | p.Met42Val | p.M42V | Q86UD3 | protein_coding | tolerated(0.38) | benign(0.013) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCH3 | SNV | Missense_Mutation | novel | c.535C>T | p.Arg179Trp | p.R179W | Q86UD3 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MARCH3 | SNV | Missense_Mutation | novel | c.167N>A | p.Val56Glu | p.V56E | Q86UD3 | protein_coding | deleterious(0) | benign(0.408) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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