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Gene: MARCH11 |
Gene summary for MARCH11 |
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Gene information | Species | Human | Gene symbol | MARCH11 | Gene ID | 441061 |
Gene name | membrane associated ring-CH-type finger 11 | |
Gene Alias | MARCH-XI | |
Cytomap | 5p15.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A6NNE9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
441061 | MARCH11 | S014 | Human | Liver | HCC | 5.79e-11 | 5.06e-01 | 0.2254 |
441061 | MARCH11 | S015 | Human | Liver | HCC | 1.42e-09 | 3.41e-01 | 0.2375 |
441061 | MARCH11 | S016 | Human | Liver | HCC | 5.38e-24 | 6.77e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARCH11 | SNV | Missense_Mutation | c.726N>C | p.Lys242Asn | p.K242N | A6NNE9 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARCH11 | insertion | Frame_Shift_Ins | novel | c.972_973insATGTATAATGATTTCAAGTACCAACTTATAAAAGATGT | p.Asp325MetfsTer37 | p.D325Mfs*37 | A6NNE9 | protein_coding | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MARCH11 | deletion | Frame_Shift_Del | novel | c.1152_1192delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Asp385SerfsTer9 | p.D385Sfs*9 | A6NNE9 | protein_coding | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
MARCH11 | SNV | Missense_Mutation | c.1009G>C | p.Glu337Gln | p.E337Q | A6NNE9 | protein_coding | tolerated(0.12) | benign(0.053) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
MARCH11 | SNV | Missense_Mutation | novel | c.1134T>G | p.Asn378Lys | p.N378K | A6NNE9 | protein_coding | deleterious(0.03) | benign(0.122) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
MARCH11 | SNV | Missense_Mutation | c.577C>T | p.Arg193Trp | p.R193W | A6NNE9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
MARCH11 | SNV | Missense_Mutation | c.778N>G | p.Thr260Ala | p.T260A | A6NNE9 | protein_coding | tolerated(0.13) | benign(0.131) | TCGA-AD-6548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARCH11 | SNV | Missense_Mutation | c.859T>C | p.Tyr287His | p.Y287H | A6NNE9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARCH11 | SNV | Missense_Mutation | c.847N>C | p.Cys283Arg | p.C283R | A6NNE9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DM-A1D8-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MARCH11 | SNV | Missense_Mutation | c.1165G>T | p.Asp389Tyr | p.D389Y | A6NNE9 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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